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Plasma membrane anion exchange protein of wide distribution. Zusätzlich bieten wir Ihnen SLC4A3 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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SLC4A3 remains an excellent candidate gene for human retinal degeneration, and with the advent of whole exome and whole genome sequencing of cohorts of molecularly unsolved patients with syndromic and non-syndromic forms of retinal degeneration
It was concluded that the A867D allele is a functional mutant of AE3 and that the decreased activity of this mutation may cause changes in cell volume and abnormal intracellular pH.
These findings suggest a new type of neuron-astrocyte communication, based on the expression of AE3 in neurons, which could explain how AE3 reduces seizure susceptibility
Ae3 is expressed in murine kidney at very low levels.
Report the importance of AE3-mediated Cl-/HCO3- exchange in cardiovascular pH regulation and the development of cardiomyocyte hypertrophy.
In the TM180 cardiomyopathy model, loss of AE3 had no apparent anti-hypertrophic effect and led to more rapid decompensation and heart failure.
Identification of Slc4a3 as underlying a previously unrecognized cause of blindness suggests this gene as a new candidate for a subset of hereditary vitreoretinal retinal degeneration
AE3 modulates seizure susceptibility in knockout mice.
Show that AE3 expression profoundly influences control of breathing in mice.
AE3 and NKCC1 (zeige SLC12A2 Antikörper) affect Ca2 (zeige CA2 Antikörper)+ handling
In hippocampal neurons dissociated from anion exchanger AE3 knock-out mice, ammonium-induced alkalinization was much larger than that seen in neurons from wild-type mice.
Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-).
anion exchange protein 3
, AE 3
, Anion exchanger 3, neuronal
, cardiac/brain band 3-like protein
, neuronal band 3-like protein
, solute carrier family 4 member 3
, anion exchanger 3 cardiac isoform
, Solute carrier family 4, member 3, anion exchange protein 3
, anion exchanger 3
, band 3-related protein 3
, anion exchanger 3 brain isoform