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SLC29A4 is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. Zusätzlich bieten wir Ihnen Solute Carrier Family 29 (Nucleoside Transporters), Member 4 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines predominantly through PMAT.
Transport kinetic analysis revealed that I89M mutant in PMAT protein had a 2.7-fold reduction in maximal transport velocity with no significant change in apparent binding affinity.
Data show that ENT1 (zeige SLC29A1 Antikörper), ENT2 (zeige SLC29A2 Antikörper), ENT4 and CNT3 (zeige SLC28A3 Antikörper) protein was detected on ovarian carcinoma cells in all effusions, with expression observed in 1-95% of tumor cells.
The selectivity and kinetics of monoamine neurotransmitter transport by PMAT and OCT3 (zeige POU5F1 Antikörper) was determined. PMAT is expressed at much higher levels than hOCT3 in brain, whereas hOCT3 is selectively and highly expressed in adrenal gland and skeletal muscle.
PMAT can function as a polyspecific organic cation transporter, which may play a role in organic cation transport in vivo.
ENT4, in addition to playing roles in cardiac serotonin transport, contributes to the regulation of extracellular adenosine concentrations, in particular under the acidotic conditions associated with ischemia.
our data suggest that PMAT is expressed on the apical membranes of renal epithelial cells and may use luminal proton gradient to drive organic cation reabsorption in the kidney.
PMAT, EMT (zeige ITK Antikörper), and OCT2 transporters are expressed in the endometrial stroma and can potentially regulate reuptake of monoamines in general and histamine in particular.
identification of ENT4 as a highly expressed transcript in desmoplastic small round cell tumor (DSRCT) may represent an attractive pathway for targeting chemotherapeutic drugs into DSRCT
The data suggest that PMAT is specifically expressed in podocytes and may play an important role in puromycin aminonucleoside-induced kidney injury.
PMAT is a major transporter for choroid plexus uptake of bioactive amines and xenobiotic cations.
This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized.
equilibrative nucleoside transporter 4
, solute carrier family 29 member 4
, solute carrier family 29 (nucleoside transporters), member 4
, plasma membrane monoamine transporter