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SLC25A5 is a member of the mitochondrial carrier subfamily of solute carrier protein genes. Zusätzlich bieten wir Ihnen SLC25A5 Kits (12) und SLC25A5 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Deficiency in the mouse mitochondrial ANT2 gene is associated with cardiac noncompaction.
IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2
Erythroid and B-cell development may be particularly vulnerable to Ant2 depletion-mediated mitochondrial dysfunction and oxidative stress.
Sirt4 (zeige SIRT4 Antikörper) regulates ATP levels via ANT2 and a feedback loop involving AMPK (zeige PRKAA1 Antikörper).
The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
ANT2 and ANT1 (zeige SLC25A4 Antikörper) regulate L1-mediated neurite outgrowth in conjunction with MMP14 (zeige MMP14 Antikörper) at the plasma membrane.
In liver only Ant2 mRNA was found, but in brown adipose tissue, Ant1 & Ant2 mRNA levels were equal. The ANT2 isoform may mediate fatty-acid-induced uncoupling.
At high protonmotive force, an endogenously generated activator stimulates proton conductance catalysed partly by UCP3 (zeige UCP3 Antikörper) and partly by the adenine nucleotide translocase.
Findings suggest that ANT2 overexpression contributes to EGFR (zeige EGFR Antikörper)-TKI resistance in non-small cell lung cancer.
Study found that ANT2 was upregulated in sorafenibresistant hepatocellular carcinoma Huh7 cell line and its overexpression promoted sorafenib resistance.
ANT2 shRNA downregulates miR (zeige MLXIP Antikörper)-19a and miR (zeige MLXIP Antikörper)-96 through the PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) pathway and suppresses tumor growth in hepatocellular carcinoma cells.
TGF-beta (zeige TGFB1 Antikörper)-mediated suppression of ANT2 through NF1 (zeige NF1 Antikörper)/Smad4 (zeige SMAD4 Antikörper) complexes contributes to oxidative stress and DNA damage during induction of cellular senescence.
ANT2 suppression by shRNA may be able to exert anticancer effects in HCC (zeige FAM126A Antikörper) further by restoring SOCS1 (zeige SOCS1 Antikörper) expression
SLC25A5 is involved in memory formation or establishment, which could add mitochondrial processes to the wide array of pathways that regulate normal cognitive functions.
miR (zeige MLXIP Antikörper)-636 might function as a tumor suppressor miRNA affecting hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) tumorigenesis via downregulation of Ras, and that ANT2 suppression by shRNA could exert an anticancer effect by restoring miR (zeige MLXIP Antikörper)-636 expression in HCC (zeige FAM126A Antikörper).
Apigenin upregulates DR5 and enhances TRAIL induced apoptosis by binding and inhibiting ANT2.
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.
adenine nucleotide translocator 2
, ADP,ATP carrier protein 2
, ADP/ATP translocase 2
, ANT 2
, adenine nucleotide translocase
, adenine nucleotide translocator 2, fibroblast
, solute carrier family 25 member 5
, ADP,ATP carrier protein, fibroblast isoform
, ADP/ATP carrier protein
, adenine nucleotide translocator 2 (fibroblast)
, Adenine nucleotid translocator 2 fibroblast isoform (ATP-ADP carrier protein)
, Adenine nucleotid translocator 2, fibroblast isoform (ATP-ADP carrier protein)
, adenine nucleotide translocator 2 fibroblast isoform (ATP-ADP carrier protein)
, adenine nucleotide translocator 2, fibroblast isoform (ATP-ADP carrier protein)