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SLC24A2 encodes a member of the calcium/cation antiporter superfamily of transport proteins. Zusätzlich bieten wir Ihnen SLC24A2 Antikörper (12) und und viele weitere Produktgruppen zu diesem Protein an.
Studies describe for the first time the exact location of K(+)-dependent Na(+)/Ca(2)-exchanger (solute carrier family 24, member 2) in the hippocampus of adult mice.
non-synonymous single nucleotide polymorphism in SLC24A5 (zeige SLC24A5 ELISA Kits) alters a residue that is important for NCKX5 (zeige SLC24A5 ELISA Kits) and NCKX2 activity
NCKX2 is involved in brain ischemia, and it may represent a new potential target to be investigated in the study of the molecular mechanisms involved in cerebral ischemia.
Mouse ortholog of rat Slc24a2 solute carrier family 24, encoding a potassium-dependent sodium-calcium exchanger (partial cds (zeige ABHD5 ELISA Kits))
Functional and structural properties of the NCKX2 Na(+)-Ca (2 (zeige CA2 ELISA Kits)+)/K (+) exchanger: a comparison with the NCX1 (zeige SLC8A1 ELISA Kits) Na (+)/Ca (2 (zeige CA2 ELISA Kits)+) exchanger.
identified 31 residues that, when substituted, result in shifts in Na(+) affinity, either toward higher or lower K(m) values when compared with wild type NCKX2 (K(m) for Na(+) 58 mm)
This is the first systematic NCKX (zeige SLC24A1 ELISA Kits) mutagenesis study in which 96 residues are mutated in the human cone NCKX2 cDNA, and functional consequences of these mutations are measured.
results appear to rule out a critical importance of an intramolecular disulfide linkage in NCKX2 protein synthesis and folding as had been reported before
Glu (zeige DCTN1 ELISA Kits)(188) and Asp (zeige ASIP ELISA Kits)(548) are the central residues of a single cation binding pocket that can accommodate both K(+) and Ca(2 (zeige CA2 ELISA Kits)+). Furthermore, a single set of residues lines a transport pathway for both K(+) and Ca(2 (zeige CA2 ELISA Kits)+).
Charge-removing replacement of Asp (zeige ASIP ELISA Kits)(575) by either asparagine or cysteine rendered the mutant NCKX2 proteins independent of K(+), whereas the charge-conservative substitution of Asp (zeige ASIP ELISA Kits)(575) to glutamate (zeige GRIN1 ELISA Kits) resulted in a nonfunctional mutant NCKX2 protein
Several residues in helix H2 of NCKX2 are in the proximity of residues in helices H8 and to aspartate575 in H9; the residues found here are conserved in NCKX1 (zeige SLC24A1 ELISA Kits)-5 isoforms.
PKC-mediated activation of NCKX2 is sensitive to mutation of multiple PKC consensus sites via a mechanism that may involve several phosphorylation events
A regulatory kinetic state of calcium (Ca2 (zeige CA2 ELISA Kits)+) transport via NCKX2 Na+/Ca2 (zeige CA2 ELISA Kits)+-K+ exchangers may play a prominent role in regulation of Ca2 (zeige CA2 ELISA Kits)+ extrusion in cellular environments such as neuronal synapses that experience frequent and dynamic Ca2 (zeige CA2 ELISA Kits)+ fluxes.
This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants.
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
, Na(+)/K(+)/Ca(2+)-exchange protein 2
, potassium-dependent sodium-calcium exchanger
, retinal cone Na-Ca+K exchanger
, sodium/potassium/calcium exchanger 2
, solute carrier family 24, member 2
, cone potassium-dependent, sodium-calcium exchanger