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Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteine (SLC22A8)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Zusätzlich bieten wir Ihnen Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Antikörper (52) und Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC22A8 9376 Q8TCC7
Ratte SLC22A8 SLC22A8 83500 Q9R1U7
SLC22A8 19879 O88909
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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SLC22A8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Interaktionspartnern

Human Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Interaktionspartner

  1. The genotype of rs3088442 within the SLC22A3-LPAL2-LPA gene cluster may contribute to regulation of plasma Lp(a) levels and possibly to the severity of coronary artery disease in a Chinese Han population.

  2. Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (zeige KCNK3 Proteine)/OAT3.

  3. The putative promoter sequences from hOAT1 (SLC22A6 (zeige SLC22A6 Proteine)) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.

  4. Findings suggest specific involvement of each organic cation transporters (OCT1 (zeige POU2F1 Proteine)-3) in drug transportation.

  5. Findings suggest that OCT3 (zeige POU5F1 Proteine) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.

  6. The markers of EMT (zeige ITK Proteine) were detected by using Western blot.

  7. PPIs inhibit [(3)H]MTX (zeige MTX1 Proteine) transport via hOAT3 inhibition.

  8. Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3 (zeige OCT3 Proteine)) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD (zeige CHDH Proteine)).

  9. The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.

  10. Pemetrexed is a superior substrate to methotrexate for hOAT3.

Mouse (Murine) Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Interaktionspartner

  1. Metformin undergoes negligible metabolism, these results imply that intestinal absorption of metformin is mediated at least in part by Oct3 (zeige POU5F1 Proteine) in mice.

  2. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (zeige SLC22A6 Proteine) and OAT3).

  3. Study showed that few, if any, 5-HT (zeige DDC Proteine) neurons in the dorsal raphe are resistant to loss of Pet-1 (zeige FEV Proteine) for expression of Slc22a3 (zeige OCT3 Proteine)

  4. Findings suggest that OCT3 (zeige POU5F1 Proteine) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.

  5. These results demonstrate that OCT3 (zeige POU5F1 Proteine) is responsible for metformin accumulation and secretion in salivary glands.

  6. Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.

  7. Oat3 also plays a role in bioenergetic pathways.

  8. At the protein level, mOat3 and mOat1 (zeige SLC22A6 Proteine) exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 (zeige SLC22A6 Proteine) is male dominant due to androgen stimulation.

  9. Data indicate that the expression of the organic cation transporters Slc22a1 (zeige SLC22A1 Proteine), Slc22a2 (zeige SLC22A2 Proteine) and Slc22a3 (zeige OCT3 Proteine) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (zeige TSC1 Proteine)+/-renal tumours.

  10. Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.

Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Protein Überblick

Protein Überblick

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.

Genbezeichner und Symbole assoziert mit SLC22A8

  • solute carrier family 22 (organic anion transporter), member 8 (SLC22A8)
  • solute carrier family 22 (organic anion transporter), member 8 (Slc22a8)
  • solute carrier family 22 (organic cation transporter), member 3 (SLC22A3)
  • solute carrier family 22 (organic cation transporter), member 3 (Slc22a3)
  • EMT Protein
  • EMTH Protein
  • Oat3 Protein
  • Oct3 Protein
  • Orct3 Protein
  • Roct Protein
  • Slca22a3 Protein

Bezeichner auf Proteinebene für SLC22A8

solute carrier family 22 member 8 , organic anion transporter 3 , hOAT3 , rOat3 , solute carrier family 22 ,member 8 , rbOAT3 , renal organic anion transporter 3 , reduced in osteosclerosis transporter , solute carrier family 22, member 8 , pOAT3 , EMT organic cation transporter 3 , extraneuronal monoamine transporter , organic cation transporter 3 , solute carrier family 22 (extraneuronal monoamine transporter), member 3 , solute carrier family 22 member 3 , solute carrier family 22, member 3

GENE ID SPEZIES
451274 Pan troglodytes
100172896 Pongo abelii
9376 Homo sapiens
83500 Rattus norvegicus
476049 Canis lupus familiaris
404128 Bos taurus
100008845 Oryctolagus cuniculus
19879 Mus musculus
407774 Sus scrofa
6581 Homo sapiens
20519 Mus musculus
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