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SLC22A8 encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. Zusätzlich bieten wir Ihnen Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteine (4) und Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SLC22A8 Primary Antibody für IF (p), IHC (p) - ABIN670821
Zhou, Yu, Zhang, Liu, Lu: Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice. in Planta medica 2014
Show all 2 Pubmed References
SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.
The genotype of rs3088442 within the SLC22A3-LPAL2-LPA gene cluster may contribute to regulation of plasma Lp(a) levels and possibly to the severity of coronary artery disease in a Chinese Han population.
Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (zeige KCNK3 Antikörper)/OAT3.
The putative promoter sequences from hOAT1 (SLC22A6 (zeige SLC22A6 Antikörper)) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.
Findings suggest specific involvement of each organic cation transporters (OCT1 (zeige POU2F1 Antikörper)-3) in drug transportation.
Findings suggest that OCT3 (zeige POU5F1 Antikörper) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.
The markers of EMT (zeige ITK Antikörper) were detected by using Western blot.
PPIs inhibit [(3)H]MTX (zeige MTX1 Antikörper) transport via hOAT3 inhibition.
Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3 (zeige OCT3 Antikörper)) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD (zeige CHDH Antikörper)).
The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.
OAT1 (zeige SLC22A6 Antikörper) plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney
Metformin undergoes negligible metabolism, these results imply that intestinal absorption of metformin is mediated at least in part by Oct3 (zeige POU5F1 Antikörper) in mice.
Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (zeige SLC22A6 Antikörper) and OAT3).
Study showed that few, if any, 5-HT (zeige DDC Antikörper) neurons in the dorsal raphe are resistant to loss of Pet-1 (zeige FEV Antikörper) for expression of Slc22a3 (zeige OCT3 Antikörper)
These results demonstrate that OCT3 (zeige POU5F1 Antikörper) is responsible for metformin accumulation and secretion in salivary glands.
Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.
Oat3 also plays a role in bioenergetic pathways.
At the protein level, mOat3 and mOat1 (zeige SLC22A6 Antikörper) exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 (zeige SLC22A6 Antikörper) is male dominant due to androgen stimulation.
Data indicate that the expression of the organic cation transporters Slc22a1 (zeige SLC22A1 Antikörper), Slc22a2 (zeige SLC22A2 Antikörper) and Slc22a3 (zeige OCT3 Antikörper) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (zeige TSC1 Antikörper)+/-renal tumours.
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.
solute carrier family 22 member 8
, organic anion transporter 3
, solute carrier family 22 ,member 8
, renal organic anion transporter 3
, reduced in osteosclerosis transporter
, solute carrier family 22, member 8
, EMT organic cation transporter 3
, extraneuronal monoamine transporter
, organic cation transporter 3
, solute carrier family 22 (extraneuronal monoamine transporter), member 3
, solute carrier family 22 member 3
, solute carrier family 22, member 3