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The protein encoded by SLC17A3 is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SLC17A3 Primary Antibody für IHC, IHC (p) - ABIN4354061
Jutabha, Anzai, Kitamura, Taniguchi, Kaneko, Yan, Yamada, Shimada, Kimura, Katada, Fukutomi, Tomita, Urano, Yamanaka, Seki, Fujita, Moriyama, Yamada, Uchida, Wempe, Endou, Sakurai: Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. in The Journal of biological chemistry 2010
Study used rs548987 of SLC17A3 as a candidate variant of ischemic stroke and performed association analysis in a Chinese population; although rs548987 failed to show significant association with total ischemic stroke and large vessel disease subtype, the C allele of rs548987 showed significant association with small vessel disease subtype of ischemic stroke (OR=0.68, p=0.004).
hNPT4 (SLC17A3) mediated time- and concentration-dependent uptake of OTxA (K(m): 802.8 microM) in a pH- and voltage-sensitive manner.
Genetic variants within SLC2A9 (zeige SLC2A9 Antikörper),ABCG2 (zeige ABCG2 Antikörper) and SLC17A3 are associated with uric acid levels
a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 (zeige KCNK3 Antikörper) and/or OAT3 (zeige SLC22A8 Antikörper) from the blood exits from the cell into the lumen via hNPT4.
SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation.
mutation reduces the phosphate transport efficiency, possibly modulating the G6-Pase (zeige G6PC Antikörper) complex
The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum.
sodium-dependent phosphate transport protein 4
, Na/Pi cotransporter 4
, sodium-phosphate cotransporter
, solute carrier family 17 (sodium phosphate), member 3
, Na(+)/PI cotransporter 4
, sodium/phosphate cotransporter 4