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Proton-linked monocarboxylate transporter. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Study demonstrates that disruption of SLC16A11 in primary human hepatocytes leads to Type 2 diabetes (T2D)-relevant changes in fatty acid and lipid metabolism; these results implicate reduced SLC16A11 function in liver as a causal factor for T2D.
Our study identified an association between the SLC16A11 variant rs75493593 and type 2 diabetes in American Indians, where the effect on diabetes was much more pronounced in nonobese individuals. rs75493593 was also associated with RNASEK gene expression.
Genetic association studies show that common variants in ABCA1 (zeige ABCA1 Antikörper) and SLC16A11 are involved in type 2 diabetes (T2D) susceptibility. Particularly, the variants rs10811661 (CDKN2A (zeige CDKN2A Antikörper)/2B) and rs9282541 (ABCA1 (zeige ABCA1 Antikörper)) are associated with T2D in adult Maya population.
Despite type 2 diabetes having been well studied by GWAS in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity).
, monocarboxylate transporter 11
, novel RNA polymerase Rpb1 C-terminal repeat domain containing protein
, solute carrier family 16 member 11
, solute carrier family 16, member 11
, monocarboxylic acid transporter 11
, solute carrier family 16 (monocarboxylic acid transporters), member 11