Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) Proteine (SLC16A1)

The protein encoded by SLC16A1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Zusätzlich bieten wir Ihnen SLC16A1 Antikörper (87) und SLC16A1 Kits (23) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC16A1 6566 P53985
SLC16A1 20501 P53986
Ratte SLC16A1 SLC16A1 25027 P53987
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$333.33
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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SLC16A1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) Interaktionspartnern

Human Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) Interaktionspartner

  1. MCT1 (zeige CMA1 Proteine) inhibitor AZD3965 increased MCT4 (zeige SLC16A4 Proteine)-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux.

  2. Silencing or genetic deletion of MCT1 (zeige CMA1 Proteine) in vivo inhibited migration, invasion, and spontaneous metastasis.

  3. The reversible H(+)/lactate(-) symporter MCT1 (zeige CMA1 Proteine) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.

  4. Increased miR (zeige MLXIP Proteine)-210 and concomitant decreased ISCU (zeige ISCU Proteine) RNA levels were found in ~40% of tumors and this was significantly associated with HIF-1alpha (zeige HIF1A Proteine) and CAIX (zeige CA9 Proteine), but not MCT1 (zeige CMA1 Proteine) or MCT4 (zeige SLC16A4 Proteine), over-expression.

  5. Data show that metastasis-associated in colon cancer-1 (MACC1 (zeige MACC1 Proteine)) and monocarboxylate transporter 1 (MCT1) are highly expressed in gastric cancer indicating poor prognosis.

  6. AA genotype of the MCT1 (zeige CMA1 Proteine) T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s Wingate Anaerobic test and during intermittent sprint tests in Japanese wrestlers

  7. MCT1 (zeige CMA1 Proteine) and MCT4 (zeige SLC16A4 Proteine) expression levels were associated with worse prognosis and shorter overall survival.

  8. MCT1 (zeige CMA1 Proteine) may be acting as an uptake transporter and MCT4 (zeige SLC16A4 Proteine) as an efflux system across the basolateral membrane for ferulic acid, and that this process is stimulated by butyric acid.

  9. After indirect co-culture, OP was increased in the BxPc-3 and Panc-1 cells; correspondingly, succinate dehydrogenase (zeige SDHA Proteine), FH and MCT (zeige MCAT Proteine) expression were increased. After the MCT1 (zeige CMA1 Proteine)-specific inhibitor removed 'tumor-stromal' metabolic coupling, the migration and invasion abilities of the pancreatic cancer cells were decreased.

  10. Data suggest that inhibition of mnocarboxylate transporters MCT1 (zeige CMA1 Proteine) and MCT4 (zeige SLC16A4 Proteine) may have clinical relevance in pancreatic ductal adenocarcinoma (PDAC).

Zebrafish Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) Interaktionspartner

  1. Data indicate that monocarboxylate transporters (MCTs1 (zeige MCTS1 Proteine)-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.

Horse (Equine) Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) Interaktionspartner

  1. The expression of monocarboxylic acid transporter 1 (MCT1), MCT2, and CD147 in 3 horse breeds with different atheletic demands is reported.[MCT1; MCT2]

  2. Results indicated that a single IET resulted in transient increases in MCT1 (zeige MCTS1 Proteine) and MCT4 (zeige SLC16A3 Proteine) mRNA expression and protein content in untrained and trained horses.

  3. The coding sequence of MCT1 (zeige MCTS1 Proteine), MCT4 (zeige SLC16A3 Proteine), and CD147 in healthy horses, and the incidence of polymorphisms of these proteins in horses with excercise-induced myopathy are reported.

  4. MCT1 (zeige MCTS1 Proteine) protein content in GMM samples obtained when the horses were 24 months old was significantly higher than at 2 months of age. However, MCT4 (zeige SLC16A3 Proteine) protein content remained unchanged throughout the study period.

Mouse (Murine) Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) Interaktionspartner

  1. Silencing or genetic deletion of MCT1 (zeige MCTS1 Proteine) in vivo inhibited migration, invasion, and spontaneous metastasis.

  2. It was concluded that both MCT1 (zeige MCTS1 Proteine) and CAII (zeige CA2 Proteine) are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise. The improved muscle function and resistance to fatigue in MCT1 (zeige MCTS1 Proteine)(+/-) mice remain unexplained.

  3. Exercise-induced changes in tumour LDH-B (zeige LDHB Proteine) and MCT1 (zeige MCTS1 Proteine) expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice

  4. Chronic lactate administration after exercise increases MCT1 (zeige MCTS1 Proteine) protein expression, which can be involved in the regulation of the observed increase in muscle glycogen (zeige GYS1 Proteine) storage after exercise training.

  5. This study showed that mouse MCT1 (zeige MCTS1 Proteine), MCT2, and MCT4 (zeige SLC16A3 Proteine) are expressed in the PNS. While DRG neurons express MCT1 (zeige MCTS1 Proteine), myelinating Schwann cells.

  6. These data for the first time demonstrate that MCT1 (zeige MCTS1 Proteine) is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush

  7. in Parkinson's disease, the levels of MCT1 (zeige MCTS1 Proteine), MCT2 and GLUT1 (zeige SLC2A1 Proteine) is not changed following dopaminergic neurodegeneration

  8. results suggest that a reduction in mitochondria is a result, rather than the cause, of the metabolic deficiency observed in Basigin-null mice, and likely occurs because of reduced metabolic activity in the absence of MCT1 (zeige MCTS1 Proteine) expression.

  9. miR (zeige MLXIP Proteine)-29a, miR (zeige MLXIP Proteine)-29b selectively target MCT1 (zeige MCTS1 Proteine) 3'UTR ; the miR (zeige MLXIP Proteine)-29 isoforms are highly expressed in islets and contribute to silencing Mct1 (zeige MCTS1 Proteine) in beta cells; miR (zeige MLXIP Proteine)-29 isoforms contribute to beta-cell-specific silencing of the MCT1 (zeige MCTS1 Proteine) transporter and may affect insulin (zeige INS Proteine) release

  10. monocarboxylate transporter 1 (MCT1), is highly enriched within oligodendroglia and disruption of this transporter produces axon damage and neuron loss in animal and cell culture models; in addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 (zeige MCTS1 Proteine) in pathogenesis

Cow (Bovine) Solute Carrier Family 16, Member 1 (Monocarboxylic Acid Transporter 1) (SLC16A1) Interaktionspartner

  1. This study confirmed age-dependent changes of MCT1 (zeige MCTS1 Proteine) expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.

  2. These findings show that MCT 1 (zeige MCTS1 Proteine) increases with the development of rumen function and also in adult animals MCT 1 (zeige MCTS1 Proteine) may change with the feeding.

  3. The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.

  4. The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.

SLC16A1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.

Genbezeichner und Symbole assoziert mit SLC16A1

  • solute carrier family 16 member 1 (SLC16A1)
  • solute carrier family 16 (monocarboxylate transporter), member 1b (slc16a1b)
  • solute carrier family 16 member 1 S homeolog (slc16a1.S)
  • solute carrier family 16 (monocarboxylic acid transporters), member 1 (Slc16a1)
  • solute carrier family 16 member 1 (Slc16a1)
  • AL022710 Protein
  • cb517 Protein
  • DKFZp469B1212 Protein
  • HHF7 Protein
  • MCT Protein
  • Mct1 Protein
  • MCT1a Protein
  • MGC52993 Protein
  • RATMCT1 Protein
  • RNMCT1 Protein
  • SLC16A1 Protein
  • zgc:55682 Protein

Bezeichner auf Proteinebene für SLC16A1

MCT 1 , monocarboxylate transporter 1 , solute carrier family 16 (monocarboxylic acid transporters), member 1 , solute carrier family 16 member 1 , solute carrier family 16, member 1 (monocarboxylic acid transporter 1) , MCT1 , monocarboxylate transporter 1a , monocarboxylate transporter 1-like , solute carrier 16 (monocarboxylic acid transporter), member 1 , Monocarboxylate transporter 1 , monocarboxylate transporter 1-like protein , solute carrier family 16 (monocarboxylate transporter), member 1

GENE ID SPEZIES
6566 Homo sapiens
368274 Danio rerio
380088 Xenopus laevis
443456 Ovis aries
457096 Pan troglodytes
100009694 Equus caballus
100174496 Pongo abelii
100398254 Callithrix jacchus
100480919 Ailuropoda melanoleuca
100582053 Nomascus leucogenys
20501 Mus musculus
25027 Rattus norvegicus
505775 Bos taurus
100775004 Cricetulus griseus
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