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The protein encoded by SLC16A1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Zusätzlich bieten wir Ihnen SLC16A1 Antikörper (77) und SLC16A1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Data indicate that monocarboxylate transporters (MCTs1 (zeige MCTS1 ELISA Kits)-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.
The expression of monocarboxylic acid transporter 1 (MCT1 (zeige MCTS1 ELISA Kits)), MCT2 (zeige SLC16A7 ELISA Kits), and CD147 in 3 horse breeds with different atheletic demands is reported.[MCT1 (zeige MCTS1 ELISA Kits); MCT2 (zeige SLC16A7 ELISA Kits)]
Results indicated that a single IET resulted in transient increases in MCT1 (zeige MCTS1 ELISA Kits) and MCT4 (zeige SLC16A3 ELISA Kits) mRNA expression and protein content in untrained and trained horses.
The coding sequence of MCT1 (zeige MCTS1 ELISA Kits), MCT4 (zeige SLC16A3 ELISA Kits), and CD147 in healthy horses, and the incidence of polymorphisms of these proteins in horses with excercise-induced myopathy are reported.
MCT1 (zeige MCTS1 ELISA Kits) protein content in GMM samples obtained when the horses were 24 months old was significantly higher than at 2 months of age. However, MCT4 (zeige SLC16A3 ELISA Kits) protein content remained unchanged throughout the study period.
The reversible H(+)/lactate(-) symporter MCT1 (zeige CMA1 ELISA Kits) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.
Increased miR (zeige MLXIP ELISA Kits)-210 and concomitant decreased ISCU (zeige ISCU ELISA Kits) RNA levels were found in ~40% of tumors and this was significantly associated with HIF-1alpha (zeige HIF1A ELISA Kits) and CAIX (zeige CA9 ELISA Kits), but not MCT1 (zeige CMA1 ELISA Kits) or MCT4, over-expression.
Data show that metastasis-associated in colon cancer-1 (MACC1 (zeige MACC1 ELISA Kits)) and monocarboxylate transporter 1 (MCT1) are highly expressed in gastric cancer indicating poor prognosis.
AA genotype of the MCT1 (zeige CMA1 ELISA Kits) T1470A polymorphism is over-represented in wrestlers compared with controls and is associated with lower blood lactate concentrations after 30-s Wingate Anaerobic test and during intermittent sprint tests in Japanese wrestlers
MCT1 (zeige CMA1 ELISA Kits) and MCT4 expression levels were associated with worse prognosis and shorter overall survival.
MCT1 (zeige CMA1 ELISA Kits) may be acting as an uptake transporter and MCT4 as an efflux system across the basolateral membrane for ferulic acid, and that this process is stimulated by butyric acid.
After indirect co-culture, OP was increased in the BxPc-3 and Panc-1 cells; correspondingly, succinate dehydrogenase (zeige SDHA ELISA Kits), FH and MCT expression were increased. After the MCT1 (zeige CMA1 ELISA Kits)-specific inhibitor removed 'tumor-stromal' metabolic coupling, the migration and invasion abilities of the pancreatic cancer cells were decreased.
Data suggest that inhibition of mnocarboxylate transporters MCT1 (zeige CMA1 ELISA Kits) and MCT4 may have clinical relevance in pancreatic ductal adenocarcinoma (PDAC).
Results found that MCT contributes to endothelial cell growth and tube formation via up-regulation of angiopoietin-1 (zeige ANGPT1 ELISA Kits) expression suggesting that MCT plays an important role in pancreatic cancer angiogenesis and tumor growth via activating the angiopoietin-1 (zeige ANGPT1 ELISA Kits) pathway.
The targeting of MCT1 (zeige CMA1 ELISA Kits) and PFKFB3 (zeige PFKFB3 ELISA Kits) regulated cell proliferation.
It was concluded that both MCT1 (zeige MCTS1 ELISA Kits) and CAII (zeige CA2 ELISA Kits) are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise. The improved muscle function and resistance to fatigue in MCT1 (zeige MCTS1 ELISA Kits)(+/-) mice remain unexplained.
Exercise-induced changes in tumour LDH-B (zeige LDHB ELISA Kits) and MCT1 (zeige MCTS1 ELISA Kits) expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice
Chronic lactate administration after exercise increases MCT1 (zeige MCTS1 ELISA Kits) protein expression, which can be involved in the regulation of the observed increase in muscle glycogen (zeige GYS1 ELISA Kits) storage after exercise training.
This study showed that mouse MCT1 (zeige MCTS1 ELISA Kits), MCT2 (zeige SLC16A7 ELISA Kits), and MCT4 (zeige SLC16A3 ELISA Kits) are expressed in the PNS. While DRG neurons express MCT1 (zeige MCTS1 ELISA Kits), myelinating Schwann cells.
These data for the first time demonstrate that MCT1 (zeige MCTS1 ELISA Kits) is critical for regeneration of both sensory and motor axons in mice following sciatic nerve crush
in Parkinson's disease, the levels of MCT1 (zeige MCTS1 ELISA Kits), MCT2 (zeige SLC16A7 ELISA Kits) and GLUT1 (zeige SLC2A1 ELISA Kits) is not changed following dopaminergic neurodegeneration
results suggest that a reduction in mitochondria is a result, rather than the cause, of the metabolic deficiency observed in Basigin-null mice, and likely occurs because of reduced metabolic activity in the absence of MCT1 (zeige MCTS1 ELISA Kits) expression.
miR (zeige MLXIP ELISA Kits)-29a, miR (zeige MLXIP ELISA Kits)-29b selectively target MCT1 (zeige MCTS1 ELISA Kits) 3'UTR (zeige UTS2R ELISA Kits) ; the miR (zeige MLXIP ELISA Kits)-29 isoforms are highly expressed in islets and contribute to silencing Mct1 (zeige MCTS1 ELISA Kits) in beta cells; miR (zeige MLXIP ELISA Kits)-29 isoforms contribute to beta-cell-specific silencing of the MCT1 (zeige MCTS1 ELISA Kits) transporter and may affect insulin (zeige INS ELISA Kits) release
monocarboxylate transporter 1 (MCT1), is highly enriched within oligodendroglia and disruption of this transporter produces axon damage and neuron loss in animal and cell culture models; in addition, this same transporter is reduced in patients with, and in mouse models of, amyotrophic lateral sclerosis, suggesting a role for oligodendroglial MCT1 (zeige MCTS1 ELISA Kits) in pathogenesis
It was shown that forced overexpression of MSlc16a1 in beta-cells replicates the key features of exercise-induced hyperinsulinism and highlights the importance of this transporter's absence from these cells for the normal control of insulin (zeige INS ELISA Kits) secretion.
This study confirmed age-dependent changes of MCT1 (zeige MCTS1 ELISA Kits) expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.
These findings show that MCT 1 (zeige MCTS1 ELISA Kits) increases with the development of rumen function and also in adult animals MCT 1 (zeige MCTS1 ELISA Kits) may change with the feeding.
The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.
The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.
, monocarboxylate transporter 1
, monocarboxylate transporter 1a
, solute carrier family 16 (monocarboxylic acid transporters), member 1
, solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
, solute carrier family 16 member 1
, monocarboxylate transporter 1-like
, MCT 1
, solute carrier 16 (monocarboxylic acid transporter), member 1