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facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen Solute Carrier Family 13 Member 2 Proteine (6) und Solute Carrier Family 13 Member 2 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SLC13A2 Primary Antibody für ELISA, WB - ABIN522497
Bergeron, Bürzle, Kovacs, Simonin, Hediger: Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. in The Journal of biological chemistry 2011
Mapping Functionally Important Residues in the Na(+)/Dicarboxylate Cotransporter, NaDC1.
NaDC1 is present throughout the entire proximal tubule, but was not detected in kidney tumors.
cyclophilin (zeige PPIA Antikörper) isoform B is likely responsible for down-regulation of carrier expression by CsA (zeige ERCC8 Antikörper) and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase (zeige FKBP1B Antikörper) activity.
study concludes most of the naturally occurring nonsynonymous SNPs affect protein processing of NaDC1; several also affect functional properties; mutations are predicted to decrease transport activity
This paper describes the cloning and functional characterization of the human Na(+)-coupled citrate transporter (NaCT).
Data show that the sodium-dependent dicarboxylate co-transporter protein (zeige HNRNPU Antikörper) 1 is located in renal proximal tubule lumenal membranes, and that the C-terminal sequence is required for delivery and targeting and may contain the signal sequence.
The Ser (zeige SIGLEC1 Antikörper) or Thr (zeige TRH Antikörper) at position 509 is the most important determinant of functional differences in apparent affinity for substrate and cations. The cation and substrate binding sites are located in close proximity to one another.
Slc26a6 (zeige SLC26A6 Antikörper)-null mice exhibit increased renal and intestinal sodium-dependent succinate uptake, as well as urinary hyperoxaluria and hypocitraturia, but no change in urinary pH, indicating enhanced transport activity of NaDC-1.
The acid-activated pathway mediating stimulation of kidney NaDC-1 activity requires a functional ET(B (zeige EDNRB Antikörper)) receptor in vivo and in vitro.
Substrate-dependent inward currents, measured using two-electrode voltage clamp, were similar for glutarate & succinate in Xenopus oocytes expressing mouse NaDC1. Currents evoked by glutarate in rabbit NaDC1 were about 5% of succinate-dependent currents.
Sodium dicarboxylate cotransporter is involved in regulating levels of various Krebs cycle intermediates in the kidney, although impaired uptake of these intermediates does not significantly affect renal function under normal or ischemic stress.
Data show that NaDC1 F336C had increased transport activity due to an increased Vmax for succinate.
facilitates sodium dependent transport of Krebs cycle intermediates including citrate, succinate, alpha-ketoglutarate, and oxaloacetate
Na(+)-coupled citrate transporter
, Na(+)/dicarboxylate cotransporter 1
, renal sodium/dicarboxylate cotransporter
, solute carrier family 13 member 2
, intestinal sodium/dicarboxylate cotransporter
, sodium-dependent dicarboxylate transporter
, solute carrier family 13, member 2
, solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
, sodium/dicarboxylate co-transporter
, sodium/dicarboxylate cotransporter
, mucin 2, intestinal/tracheal
, solute carrier family 13 (sodium-dependent citrate transporter), member 5 L homeolog