Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) ELISA Kits

SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. Zusätzlich bieten wir Ihnen SLC12A1 Antikörper (91) und SLC12A1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
SLC12A1 6557 Q13621
SLC12A1 25065  
SLC12A1 20495 P55014
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.122 ng/mL 0.31-20 ng/mL 96 Tests Anmelden zum Anzeigen 11 bis 15 Tage
592,59 €
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Human 0.188 ng/mL   96 Tests Anmelden zum Anzeigen 20 bis 26 Tage
911,84 €
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Maus
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Ratte
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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k.A.
  10 reactions Anmelden zum Anzeigen 8 bis 11 Tage
661,16 €
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Weitere ELISA Kits für SLC12A1 Interaktionspartner

Human Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Interaktionspartner

  1. A novel variant in the SLC12A1 gene, c.1614T>A, which predicts a change from a tyrosine codon to a stop codon (p.Tyr538Ter) was found in two families with Bartter syndrome type I.

  2. Low SLC12A1 urine levels were associated with Bartter syndrome.

  3. Mutations in SLC12A1 gene is associated with Bartter syndrome.

  4. Urinary NKCC2 increased in chronic kidney disease patients and decreased in controls in response to hypertonic saline.

  5. The association between polymorphisms in KCNJ1 (zeige KCNJ1 ELISA Kits), SLC12A1, and 7 other genes and calcium intake and colorectal neoplasia risk was studied.

  6. overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.

  7. NKCC2 mutations result in impaired apical targeting and function of NKCC2 transporter and give rise to a pathological phenotype known as type I Bartter syndrome. (Review)

  8. Data show that intracellular association between WNK1 (zeige WNK1 ELISA Kits) and oxidative stress-responsive 1 (OSR1 (zeige OXSR1 ELISA Kits)) is required for stimulation of OSR1 (zeige OXSR1 ELISA Kits) and Na(+), K(+), Cl(-)-Cotransporter NKCC1 (zeige SLC12A2 ELISA Kits) and NKCC2 activities by osmotic stress.

  9. NKCC1 (zeige SLC12A2 ELISA Kits) and NKCC2 were expressed in the gastric mucosa of rat, mouse and human.

  10. The Wnk3 (zeige WNK3 ELISA Kits) protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (zeige SLC12A2 ELISA Kits)/2 and NCC (zeige SLC12A3 ELISA Kits) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

Mouse (Murine) Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Interaktionspartner

  1. The differential regulation of ROMK (zeige KCNJ1 ELISA Kits), large-conductance Ca(2 (zeige CA2 ELISA Kits)+)-activated K(+) (BK) channel (zeige KCNMA1 ELISA Kits), BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 (zeige WNK1 ELISA Kits) pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.

  2. VAMP3 (zeige VAMP3 ELISA Kits) is required for normal NKCC2 expression, renal function, and blood pressure.

  3. IL-1 (zeige IL1A ELISA Kits) receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 co-transporter in the nephron.

  4. Data suggest renal cell lines exhibit an OS9- (osteosarcoma amplified 9 protein-)mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 prior to glycosylation/processing.

  5. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.

  6. our results suggest that NKCCs are involved in insulin (zeige INS ELISA Kits) secretion and that a single Slc12a2 (zeige SLC12A2 ELISA Kits) allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1.

  7. Vasopressin (zeige AVP ELISA Kits) plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport.

  8. In this systemic analysis no clear primary effects of the Slc12a1I299F mutation appeared for the organs other than the kidneys where Slc12a1 expression has been described.

  9. increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase

  10. Differential splicing of NKCC2 contributes to the adaptive capacity of the kidney to cope with changes in reabsorptive needs.

SLC12A1 Antigen-Profil

Beschreibung des Gens

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.

Genbezeichner und Symbole assoziert mit SLC12A1

  • si:ch211-220f12.1 (si:ch211-220f12.1) Antikörper
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (SLC12A1) Antikörper
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1) Antikörper
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (Slc12a1) Antikörper
  • solute carrier family 12, member 1 (Slc12a1) Antikörper
  • AI788571 Antikörper
  • BSC1 Antikörper
  • D630042G03Rik Antikörper
  • DKFZp469A2020 Antikörper
  • mBSC1 Antikörper
  • Nkcc2 Antikörper
  • SLC12A1 Antikörper
  • urehr3 Antikörper

Bezeichner auf Proteinebene für SLC12A1

FERM domain-containing protein 4A , Na/K/Cl cotransporter , solute carrier family 12 (sodium/potassium/chloride transporters), member 1 , solute carrier family 12 member 1-like , NKCC2A variant A , Na-K-2Cl cotransporter , bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 , kidney-specific Na-K-Cl symporter , solute carrier family 12 member 1 , Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , apical Na(2Cl)K cotransporter , solute carrier family 12, member 1 , BSC1 , bumetanide-sensitive cotransporter type 1

GENE ID SPEZIES
564713 Danio rerio
714289 Macaca mulatta
100025723 Monodelphis domestica
100173185 Pongo abelii
100414428 Callithrix jacchus
100590969 Nomascus leucogenys
6557 Homo sapiens
25065 Rattus norvegicus
415433 Gallus gallus
478292 Canis lupus familiaris
407161 Bos taurus
100328575 Oryctolagus cuniculus
20495 Mus musculus
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