anti-Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Antikörper

SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. Zusätzlich bieten wir Ihnen SLC12A1 Kits (11) und SLC12A1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SLC12A1 6557 Q13621
SLC12A1 25065  
SLC12A1 20495 P55014
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Top anti-SLC12A1 Antikörper auf antikoerper-online.de

Showing 10 out of 91 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-SLC12A1 Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti- SLC12A1 Picoband antibody, Western blotting All lanes: Anti SLC12A1  at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: JURKAT Whole Cell Lysate at 40ug Lane 3: SKOV Whole Cell Lysate at 40ug Lane 4: Mouse Kidney Tissue Lysate at 50ug Predicted bind size: 121KD Observed bind size: 121KD Anti- SLC12A1 Picoband antibody, IHC(P) IHC(P): Mouse Kidney Tissue 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
340,48 €
Details
Human Kaninchen Unkonjugiert IHC, WB NKCC2 Western Blotting, rat kidney tissue. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
423,84 €
Details
Ratte Kaninchen Unkonjugiert IHC (fro), IHC (p), WB Anti-SLC12A1 antibody, Western blotting WB: Rat Kidney Tissue Lysate Anti-SLC12A1 antibody, IHC(P) IHC(P): Rat Kidney Tissue 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
298,57 €
Details
Human Kaninchen Unkonjugiert DB, EIA, WB   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
462,00 €
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry-Paraffin: SLC12A1 Antibody [NBP1-80993] Staining of human kidney shows strong cytoplasmic and membranous positivity in tubular cells. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: NKCC2/SLC12A1 Antibody [NBP1-57622] - Jurkat cell lysate, Antibody Titration: 0.2-1 ug/ml Immunohistochemistry: NKCC2/SLC12A1 Antibody [NBP1-57622] - Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0 - 8.0 ug/ml Magnification: 400X 100 μL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
Details
Human Kaninchen HRP IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of NKCC2 protein using Rabbit Anti-NKCC2 Polyclonal Antibody . Primary Antibody: Rabbit Anti-NKCC2 Polyclonal Antibody  at 1:1000. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
465,74 €
Details
Human Kaninchen FITC IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of NKCC2 protein using Rabbit Anti-NKCC2 Polyclonal Antibody . Primary Antibody: Rabbit Anti-NKCC2 Polyclonal Antibody  at 1:1000. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
470,53 €
Details
Human Kaninchen Alkaline Phosphatase (AP) IHC, WB Western blot analysis of Rat kidney tissue lysates showing detection of NKCC2 protein using Rabbit Anti-NKCC2 Polyclonal Antibody . Primary Antibody: Rabbit Anti-NKCC2 Polyclonal Antibody  at 1:1000. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
472,92 €
Details

SLC12A1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-SLC12A1 Antikörper

  1. Human Polyclonal SLC12A1 Primary Antibody für IHC, WB - ABIN863200 : Caceres, Ares, Ortiz: cAMP stimulates apical exocytosis of the renal Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in the thick ascending limb: role of protein kinase A. in The Journal of biological chemistry 2009 (PubMed)
    Zeige alle 5 Referenzen für 863200

  2. Human Polyclonal SLC12A1 Primary Antibody für DB, EIA - ABIN493167 : Nogues, Lang, Desbat, Buffeteau, Leiserowitz: Two-dimensional crystal structure of a quaterthiophene-alkanethiol self-assembled monolayer on gold. in Langmuir : the ACS journal of surfaces and colloids 2008 (PubMed)
    Zeige alle 4 Referenzen für 493167

  3. Cow (Bovine) Polyclonal SLC12A1 Primary Antibody für IHC, WB - ABIN2776780 : Kelsen, Patel, Parker, Vera, Rimoldi, Gadepalli, Drummond, Stec: Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells. in American journal of physiology. Renal physiology 2008 (PubMed)
    Zeige alle 3 Referenzen für 2776780

  4. Human Polyclonal SLC12A1 Primary Antibody für IHC, WB - ABIN2486327 : Xue, Liu, Ji, Ren, Zhang, Zheng, Wood, Zhu: Expression of NKCC2 in the rat gastrointestinal tract. in Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2009 (PubMed)
    Zeige alle 2 Referenzen für 2486327

  5. Human Polyclonal SLC12A1 Primary Antibody für IHC, IHC (p) - ABIN4339832 : Schrödter, Braun, Syring, Klümper, Deng, Schmidt, Perner, Müller, Ellinger: Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma. in Molecular cancer 2016 (PubMed)

  6. Human Polyclonal SLC12A1 Primary Antibody für IHC, IHC (p) - ABIN4891581 : Toka, Al-Romaih, Koshy, DiBartolo, Kos, Quinn, Curhan, Mount, Brown, Pollak: Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. in Journal of the American Society of Nephrology : JASN 2012 (PubMed)

Weitere Antikörper gegen SLC12A1 Interaktionspartner

Human Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Interaktionspartner

  1. A novel variant in the SLC12A1 gene, c.1614T>A, which predicts a change from a tyrosine codon to a stop codon (p.Tyr538Ter) was found in two families with Bartter syndrome type I.

  2. Low SLC12A1 urine levels were associated with Bartter syndrome.

  3. Mutations in SLC12A1 gene is associated with Bartter syndrome.

  4. Urinary NKCC2 increased in chronic kidney disease patients and decreased in controls in response to hypertonic saline.

  5. The association between polymorphisms in KCNJ1 (zeige KCNJ1 Antikörper), SLC12A1, and 7 other genes and calcium intake and colorectal neoplasia risk was studied.

  6. overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.

  7. NKCC2 mutations result in impaired apical targeting and function of NKCC2 transporter and give rise to a pathological phenotype known as type I Bartter syndrome. (Review)

  8. Data show that intracellular association between WNK1 (zeige WNK1 Antikörper) and oxidative stress-responsive 1 (OSR1 (zeige OXSR1 Antikörper)) is required for stimulation of OSR1 (zeige OXSR1 Antikörper) and Na(+), K(+), Cl(-)-Cotransporter NKCC1 (zeige SLC12A2 Antikörper) and NKCC2 activities by osmotic stress.

  9. NKCC1 (zeige SLC12A2 Antikörper) and NKCC2 were expressed in the gastric mucosa of rat, mouse and human.

  10. The Wnk3 (zeige WNK3 Antikörper) protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (zeige SLC12A2 Antikörper)/2 and NCC (zeige SLC12A3 Antikörper) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

Mouse (Murine) Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1) Interaktionspartner

  1. The differential regulation of ROMK (zeige KCNJ1 Antikörper), large-conductance Ca(2 (zeige CA2 Antikörper)+)-activated K(+) (BK) channel (zeige KCNMA1 Antikörper), BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 (zeige WNK1 Antikörper) pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.

  2. VAMP3 (zeige VAMP3 Antikörper) is required for normal NKCC2 expression, renal function, and blood pressure.

  3. IL-1 (zeige IL1A Antikörper) receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 co-transporter in the nephron.

  4. Data suggest renal cell lines exhibit an OS9- (osteosarcoma amplified 9 protein-)mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 prior to glycosylation/processing.

  5. The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha (zeige SCNN1A Antikörper) in obstructive kidney disease, possibly via iNOS (zeige NOS2 Antikörper)-derived nitric oxide and BNP (zeige BNC2 Antikörper).

  6. our results suggest that NKCCs are involved in insulin (zeige INS Antikörper) secretion and that a single Slc12a2 (zeige SLC12A2 Antikörper) allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1.

  7. Vasopressin (zeige AVP Antikörper) plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport.

  8. In this systemic analysis no clear primary effects of the Slc12a1I299F mutation appeared for the organs other than the kidneys where Slc12a1 expression has been described.

  9. increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase

  10. Differential splicing of NKCC2 contributes to the adaptive capacity of the kidney to cope with changes in reabsorptive needs.

SLC12A1 Antigen-Profil

Protein Überblick

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.

Genbezeichner und Symbole assoziert mit SLC12A1

  • si:ch211-220f12.1 (si:ch211-220f12.1) Antikörper
  • solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (SLC12A1) Antikörper
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1) Antikörper
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (Slc12a1) Antikörper
  • solute carrier family 12, member 1 (Slc12a1) Antikörper
  • AI788571 Antikörper
  • BSC1 Antikörper
  • D630042G03Rik Antikörper
  • DKFZp469A2020 Antikörper
  • mBSC1 Antikörper
  • Nkcc2 Antikörper
  • SLC12A1 Antikörper
  • urehr3 Antikörper

Bezeichner auf Proteinebene für SLC12A1

FERM domain-containing protein 4A , Na/K/Cl cotransporter , solute carrier family 12 (sodium/potassium/chloride transporters), member 1 , solute carrier family 12 member 1-like , NKCC2A variant A , Na-K-2Cl cotransporter , bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 , kidney-specific Na-K-Cl symporter , solute carrier family 12 member 1 , Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) , apical Na(2Cl)K cotransporter , solute carrier family 12, member 1 , BSC1 , bumetanide-sensitive cotransporter type 1

GENE ID SPEZIES
564713 Danio rerio
714289 Macaca mulatta
100025723 Monodelphis domestica
100173185 Pongo abelii
100414428 Callithrix jacchus
100590969 Nomascus leucogenys
6557 Homo sapiens
25065 Rattus norvegicus
415433 Gallus gallus
478292 Canis lupus familiaris
407161 Bos taurus
100328575 Oryctolagus cuniculus
20495 Mus musculus
Ausgewählte Anbieter für anti-SLC12A1 (SLC12A1) Antikörper
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