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SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. Zusätzlich bieten wir Ihnen Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Proteine (11) und Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 86 products:
Dog (Canine) Polyclonal SLC12A3 Primary Antibody für IEM, ICC - ABIN863201
Rosenbaek, Assentoft, Pedersen, MacAulay, Fenton: Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. in The Journal of physiology 2012
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Human Polyclonal SLC12A3 Primary Antibody für IF (p), IHC (p) - ABIN872340
Jayachandran, Lugo, Heiling, Miller, Rule, Lieske: Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. in Biology of sex differences 2015
Human Polyclonal SLC12A3 Primary Antibody für ICC, IF - ABIN4354024
Bachmann, Burté, Pramana, Conte, Brown, Orimadegun, Ajetunmobi, Afolabi, Akinkunmi, Omokhodion, Akinbami, Shokunbi, Kampf, Pawitan, Uhlén, Sodeinde, Schwenk, Wahlgren, Fernandez-Reyes, Nilsson: Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. in PLoS pathogens 2014
In wild-type, total (tNCC (zeige TNNC1 Antikörper)) and phosphorylated (pNCC) NCC protein expressions were 1.8- and 4.6-fold higher in females compared with males, consistent with the larger response to HCTZ. In AT1a (zeige AGTR1a Antikörper) receptor knockout mice, tNCC (zeige TNNC1 Antikörper) and pNCC increased significantly in males to levels not different from those in females.
NCC1 (zeige CCL13 Antikörper)/2, NCC1 (zeige CCL13 Antikörper)-3, and pNCC1-3-T55/T60 are upregulated by hydrochlorothiazide, and the increase in NCC abundance in urinary extracellular vesicles of essential hypertensive patients correlates with the blood pressure response to hydrochlorothiazide.
Data show that WNK lysine deficient protein kinase 3 (zeige WNK3 Antikörper) protein (WNK3 (zeige WNK3 Antikörper)) interacts with NCC and increases the Na-Cl cotransporter (NCC) expression on the cell membrane and in cytoplasm together.
variants of the SLC12A3 gene confer susceptibility to the abnormal serum LDL-c level in the Mongolian population.
A significant association of the SLC12A3 rs11643718 and ELMO1 (zeige ELMO1 Antikörper) rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.
This paper identified a novel SLC12A3 allele in Gitelman syndrome that activates a cryptic exon flanked by interspersed repeats deep in intron 12.
SLC12A3 gene homozygous mutation is associated with Gitelman syndrome.
SNPs in the SLC12A3 gene confer susceptibility to hypertension in the Mongolian population.
Compared with patients with 1 mutant SLC12A3 allele, patients with 2 mutant SLC12A3 alleles had more severe hypomagnesemia, but did not have more severe hypokalemia.
the results of this study support that the SLC12A3 gene is a susceptibility gene for hypertension in the Mongolian population.
Potassium depletion stimulates NCC via phosphorylation and inactivation of the KLHL3 (zeige KLHL3 Antikörper) and promoting increased blood pressure.
the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4 (zeige WNK4 Antikörper)-SPAK (zeige STK39 Antikörper) signal pathway using WNK4 (zeige WNK4 Antikörper)-/- and SPAK (zeige STK39 Antikörper)-/- mice.
The Role of Epithelial Sodium Channel ENaC (zeige SCNN1A Antikörper) and the Apical Cl-/HCO3- Exchanger Pendrin (zeige SLC26A4 Antikörper) in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.
This study identifies NCC as an IL18 (zeige IL18 Antikörper)-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis.
Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db (zeige LEPR Antikörper) mice from 6, 12, and 26 weeks at the age.
SPAK (zeige STK39 Antikörper)-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure.
NCC inhibition stimulates duodenal Ca(2 (zeige CA2 Antikörper)+) absorption as well as osteoblast differentiation and bone Ca(2 (zeige CA2 Antikörper)+) storage, possibly through a FAK (zeige PTK2 Antikörper)/ERK (zeige EPHB2 Antikörper) dependent mechanism
P2Y2 (zeige P2RY2 Antikörper)-mediated increase of cytoplasmic Ca(2 (zeige CA2 Antikörper)+) concentration down-regulates the expression of NCC.
Estradiol, progesterone, and prolactin (zeige PRL Antikörper) increase renal NaCl cotransporter phosphorylation and activity.
SPAK (zeige STK39 Antikörper) is an important mediator of the increased NCC activation by phosphorylation that occurs in the distal convoluted tubule in response to a low-K(+) diet, but other low-potassium-activated kinases are likely to be involved.
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
solute carrier family 12 (sodium/chloride transporters), member 3
, thiazide-sensitive sodium chloride cotransporter
, solute carrier family 12 (sodium/chloride transporters), member 3, gene 2
, solute carrier family 12 member 3-like
, Na-Cl cotransporter
, Na-Cl symporter
, NaCl electroneutral thiazide-sensitive cotransporter
, solute carrier family 12 member 3
, thiazide-sensitive Na-Cl cotransporter
, thiazide-sensitive sodium-chloride cotransporter
, solute carrier family 12, member 3
, sodium chloride cotransporter