Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) ELISA Kits

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. Zusätzlich bieten wir Ihnen Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 Antikörper (101) und Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Ratte SLC12A5 SLC12A5 171373 Q63633
SLC12A5 57468 Q9H2X9
Anti-Maus SLC12A5 SLC12A5 57138 Q91V14
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Katalog Nr. Reaktivität Sensitivität Bereich Menge Anbieter Lieferzeit Preis Details
Human 0.107 ng/mL 0.312-20 ng/mL 96 Tests Anmelden zum Anzeigen 7 bis 14 Tage
674,40 €
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Weitere ELISA Kits für Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 Interaktionspartner

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) Interaktionspartner

  1. Study shows that the overall expression of potassium-chloride cotransporter (zeige SLC12A7 ELISA Kits)-2 is increased in the hippocampi of temporal lobe epilepsy patients.

  2. Our network model suggested the loss of KCC2 in a critical number of pyramidal cells increased external potassium and intracellular chloride concentrations leading to seizure-like field potential oscillations. These oscillations included transient discharges leading to ictal-like field events with frequency spectra as in vitro Restoration of KCC2 function suppressed seizure activity and thus may present a useful therapeut

  3. The KCC2 exerts specific functions for the maturation of glycinergic synapses in cultured spinal cord neurons.

  4. SLC12A5 plays a pivotal oncogenic role in colorectal carcinogenesis; its overexpression is an independent prognostic factor of patients with CRC (zeige CALR ELISA Kits).

  5. the functional deficit of KCC2 may offer an explanation for the delayed onset of Rett symptoms.

  6. A KCC2 mutation causes epilepsy of infancy with migrating focal seizures. Decreased KCC2 expression, reduced protein glycosylation and impaired Cl- extrusion contribute to loss of KCC2 activity, impairing synaptic inhibition and promoting excitability.

  7. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1 (zeige WNK1 ELISA Kits)-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  8. a novel signaling pathway that couples KCC2 to the cytoskeleton and regulates the formation of glutamatergic synapses.

  9. These data describe a novel KCC2 variant significantly associated with a human disease and suggest genetically encoded impairment of KCC2 functional regulation may be a risk factor for the development of human IGE.

  10. KCC2-R952H from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation.

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) Interaktionspartner

  1. TGF-beta2 (zeige TGFB2 ELISA Kits) is a new regulatory factor for KCC2 functional activation and membrane trafficking.

  2. GABAA (zeige GABRg1 ELISA Kits) receptor (GABAAR (zeige GABRG2 ELISA Kits)) and the Na(+)-K(+)-2Cl(-) cotransporter (zeige SLC12A1 ELISA Kits) (NKCC1 (zeige SLC12A2 ELISA Kits)), but not the K(+)-Cl(-) cotransporter (zeige SLC12A4 ELISA Kits) (KCC2), were expressed in the terminals of the CRH (zeige CRH ELISA Kits) neurons at the median eminence (ME). In contrast, CRH (zeige CRH ELISA Kits) neuronal somata were enriched with KCC2 but not with NKCC1 (zeige SLC12A2 ELISA Kits).

  3. GluK2 (zeige GRIK2 ELISA Kits)-mediated increase in KCC2 recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA).

  4. KCC2 expression supersedes NKCC1 (zeige SLC12A2 ELISA Kits) in mature fiber cells in mouse and rabbit lenses.

  5. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1 (zeige WNK1 ELISA Kits)-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  6. Repeated stress decreased KCC2 expression and increased NKCC1 (zeige SLC12A2 ELISA Kits) expression in membranes of granular and pyramidal cells in the hippocampus.

  7. Decreasing [Cl(-)]i levels caused by increasing KCC2 levels in the 12 N could play important roles in regulating the frequency of respiration-related rhythmic activity during development.

  8. Results showed that the fast functional up-regulation of KCC2 in the mouse hippocampus following neonatal status epilepticus is dependent on BDNF (zeige BDNF ELISA Kits)

  9. In these neurons, the plasmalemmal expression of KCC2, which establishes the low [Cl(-) ]i required for GABAA R (zeige GABRG2 ELISA Kits)-mediated inhibition

  10. Decreased KCC2 protein expression, serine 940 dephosphorylation in motoneurons was found in mice with post-stroke spasticity.

Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) Antigen-Profil

Beschreibung des Gens

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit SLC12A5

  • solute carrier family 12 (potassium/chloride transporter), member 5 (SLC12A5) Antikörper
  • solute carrier family 12 (potassium-chloride transporter), member 5 (Slc12a5) Antikörper
  • solute carrier family 12, member 5 (Slc12a5) Antikörper
  • KCC2 Antikörper
  • mKIAA1176 Antikörper

Bezeichner auf Proteinebene für SLC12A5

solute carrier family 12 (potassium/chloride transporter), member 5 , K-Cl cotransporter 2 , electroneutral potassium-chloride cotransporter 2 , furosemide-sensitive K-Cl cotransporter , neuronal K-Cl cotransporter , neuronal-specific K-Cl cotransporter , rKCC2 , solute carrier family 12 member 5 , solute carrier family 12, member 5 , erythroid K-Cl cotransporter 2 , hKCC2 , mKCC2

GENE ID SPEZIES
100155991 Sus scrofa
171373 Rattus norvegicus
57468 Homo sapiens
57138 Mus musculus
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