anti-Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) Antikörper

The protein encoded by SCN10A is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. Zusätzlich bieten wir Ihnen Sodium Channel, Voltage-Gated, Type X, alpha Subunit Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SCN10A 20264 Q6QIY3
SCN10A 6336 Q9Y5Y9
SCN10A 29571 Q62968
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Top anti-Sodium Channel, Voltage-Gated, Type X, alpha Subunit Antikörper auf antikoerper-online.de

Showing 10 out of 75 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert AA, ICC, IF, IHC, WB Nav1 8 Cos1 8 transient Western Blotting. Nav1 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
411,87 €
Details
Human Maus Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Nav1.8 Antibody (S134-12) [NBP1-47615] - Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Immunohistochemistry: Nav1.8 Antibody (S134-12) [NBP1-47615] - Mouse backskin sections. Courtesy of Dr. Turksen, Ottawa Hospital Research Institute, Canada. 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
381,00 €
Details
Maus Ziege Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 3 bis 4 Tage
249,70 €
Details
Human Maus HRP AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
453,77 €
Details
Human Maus FITC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
458,56 €
Details
Human Maus Alkaline Phosphatase (AP) AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
460,95 €
Details
Human Maus Biotin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
463,34 €
Details
Human Maus PE AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
464,54 €
Details
Human Maus Streptavidin AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
465,74 €
Details
Human Maus APC AA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20°C. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Cytoplasmic staining and some dull nuclear staining. Western Blot analysis of Monkey COS transient cell lysate showing detection of Nav1.8 protein using Mouse Anti-Nav1.8 Monoclonal Antibody, Clone S134-12 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.8 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
466,94 €
Details

SCN10A Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-Sodium Channel, Voltage-Gated, Type X, alpha Subunit Antikörper

  1. Mammalian Monoclonal SCN10A Primary Antibody für ISt, IHC - ABIN1304845 : François, Schüetter, Laffray, Sanguesa, Pizzoccaro, Dubel, Mantilleri, Nargeot, Noël, Wood, Moqrich, Pongs, Bourinet: The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function. in Cell reports 2015 (PubMed)
    Show all 17 Pubmed References

  2. Human Monoclonal SCN10A Primary Antibody für AA, ICC - ABIN863135 : Dray, Read: Arthritis and pain. Future targets to control osteoarthritis pain. in Arthritis research & therapy 2007 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen Sodium Channel, Voltage-Gated, Type X, alpha Subunit Interaktionspartner

Mouse (Murine) Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) Interaktionspartner

  1. These preclinical proof-of-concept data suggest that PF-01247324, its derivatives, or other Nav1.8-selective blockers merit further study for providing symptomatic therapy for cerebellar dysfunction in MS and related disorders.

  2. A novel splice variant of SCN10A lacking exon 11 was found in human but not detected in mouse or rat.

  3. Nav1.8 gain-of-function point mutation contributes to intense hyperexcitability along the afferent axon within distinct sensory neuron subtypes.

  4. Nav1.8 interacts with ankyrin G (zeige ANK3 Antikörper) and they co-localize in skin nerve fibers.

  5. The enhanced NaV1.8 activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain.

  6. Analysis of BAC transgenic strains harboring an engineered deletion of the enhancer within Scn10a revealed t (zeige SCN5A Antikörper)hat the enhancer was essential for Scn5a expression in cardiac tissue. SCN10A variant rs6801957 modulated Scn5a expression in the heart.

  7. Nav1.8 expression increases in dorsal root ganglion neurons following pretreatment with CC chemokine ligand 2 (zeige CXCL2 Antikörper).

  8. We demonstrate that 75% of dorsal root ganglion (DRG) neurons express Na(v)1.8-Cre, including >90% of neurons expressing markers of nociceptors.

  9. Behavioural deficits in Nav1.7 (zeige SCN9A Antikörper)/Nav1.8 knockout mice reflects a failure of action potential propagation in a mechanosensitive set of sensory neurons rather than a loss of primary transduction currents.

  10. The functional presence of SCN10A/Nav1.8 in intracardiac neurons is demonstrated, indicating a novel role for this neuronal sodium channel in regulation of cardiac electric activity.

Human Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) Interaktionspartner

  1. This study demonstrated that at the association and mechanistic levels, the SCN10A single nucleotide polymorphism rs6795970 biases human pain sensitivity.

  2. We investigated the association of SCN10A gene variants with 105 sporadic sudden unexplained nocturnal death syndrome victims. A total of 6 rare mutations and 16 polymorphisms were detected in SUNDS victims. This is the first report of common and rare variants of SCN10A gene in the Chinese Han population, which provides the genetic epidemiological evidence that SCN10A may be a novel susceptibility gene.

  3. Compared with Brugada syndrome (BrS) patients carrying SCN5A (zeige SCN5A Antikörper) or CACNA1C (zeige CACNA1C Antikörper) mutations, symptomatic patients in the SCN10A group tended to be older than those in the other gene groups. In six BrS probands who carried SCN10A variants, most experienced severe arrhythmic attacks.

  4. The p.M650K mutation shifted steady-state fast inactivation of Nav1.8 (SCN10A)to more hyperpolarized potentials and did not significantly alter any other tested gating behaviors. The AP half-width was significantly broader and the stimulated action potential firing rate was reduced for M650K transfected DRGs compared to WT.

  5. SCN10A mutations do not play primary role in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

  6. SCN10A genetic variation substantially influences functional status in patients with multiple sclerosis.

  7. SCN10A gene mutations that reduce sodium channel current may provide a mechanistic link between Atrioventricular nodal reentrant tachycardia and Brugada syndrome and predispose to expression of both phenotypes.

  8. The results demonstrate distinct properties of human Na(v)1.8, which contribute to the firing properties of human DRG neurons.

  9. The common SNP SCN10A V1073 was strongly associated with Brugada syndrome and demonstrated loss of NaV1.8 function, as did rare variants in isolated patients.

  10. study suggests that SCN10A variations are involved in the genesis of AF.

Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A) Antigen-Profil

Protein Überblick

voltage-gated sodium channel that is resistant to tetrodotoxin

Genbezeichner und Symbole assoziert mit SCN10A

  • sodium channel, voltage-gated, type X, alpha (Scn10a) Antikörper
  • sodium channel, voltage-gated, type X, alpha subunit (SCN10A) Antikörper
  • sodium channel, voltage-gated, type X, alpha subunit (Scn10a) Antikörper
  • hPN3 Antikörper
  • Na(V)1.8 Antikörper
  • Nav1.8 Antikörper
  • PN3 Antikörper
  • SNS Antikörper

Bezeichner auf Proteinebene für SCN10A

peripheral nerve sodium channel 3 , sensory neuron sodium channel , sodium channel protein type 10 subunit alpha , sodium channel protein type X subunit alpha , voltage-gated sodium channel subunit alpha Nav1.8 , sodium channel, voltage-gated, type X, alpha polypeptide , sodium channel type X alpha polypeptide , sodium channel voltage-gated type X alpha polypeptide , sodium channel, voltage-gated, type 10, alpha polypeptide , TTX-resistant sodium channel , naNG

GENE ID SPEZIES
20264 Mus musculus
6336 Homo sapiens
29571 Rattus norvegicus
477026 Canis lupus familiaris
100299477 Bos taurus
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