anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Antikörper

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Zusätzlich bieten wir Ihnen Sodium Channel, Voltage-Gated, Type I, alpha Subunit Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SCN1A 20265  
SCN1A 81574 P04774
SCN1A 6323 P35498
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Top anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit Antikörper auf antikoerper-online.de

Showing 10 out of 43 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of Nav1.1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Nav1.1 expression in SHSY5Y (A), mouse brain (B), PC12 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
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Human Kaninchen Unkonjugiert WB Western blot analysis of Scn1a expression in rat brain extract (lane 1), mouse brain extract (lane 2) and U87 whole cell lysates (lane 4). Scn1a at 250KD was detected using rabbit anti- Scn1a Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
340,48 €
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Fledermaus Kaninchen Unkonjugiert IHC (p) Anti-SCN1A / Nav1.1 antibody  ABIN1049319 IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-SCN1A / Nav1.1 antibody IHC staining of human pancreas, exocrine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1104128 concentration 20 ug/ml. 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
801,43 €
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Human Kaninchen Unkonjugiert IHC, WB   100 μL Anmelden zum Anzeigen 10 bis 12 Tage
433,02 €
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Ratte Kaninchen Unkonjugiert IHC, WB   50 μL Anmelden zum Anzeigen 15 bis 21 Tage
771,43 €
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Human Kaninchen Unkonjugiert ELISA, WB   100 μL Anmelden zum Anzeigen 11 bis 14 Tage
565,71 €
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Human Kaninchen Unkonjugiert ICC, IF Immunocytochemistry/Immunofluorescence: Scn1a Antibody  - Staining of human cell line ASC TERT1 shows localization to nucleoplasm & plasma membrane. 100 μL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
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Human Kaninchen Unkonjugiert IHC (p)   0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
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Human Kaninchen Unkonjugiert EIA, IHC (fro), WB Pancreas stained in IHC-P with SCN1A antibody 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
462,00 €
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SCN1A Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine) ,


Rat (Rattus) ,
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Am meisten referenzierte anti-Sodium Channel, Voltage-Gated, Type I, alpha Subunit Antikörper

  1. Mammalian Monoclonal SCN1A Primary Antibody für ISt, IHC - ABIN1304837 : Tian, Wang, Ke, Guo, Shu: Molecular identity of axonal sodium channels in human cortical pyramidal cells. in Frontiers in cellular neuroscience 2014 (PubMed)
    Show all 31 Pubmed References

Weitere Antikörper gegen Sodium Channel, Voltage-Gated, Type I, alpha Subunit Interaktionspartner

Mouse (Murine) Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Interaktionspartner

  1. results therefore indicate that, while Nav1.1 is expressed in MEG (zeige PTPN4 Antikörper)-derived inhibitory neurons, Nav1.2 (zeige SCN2A Antikörper) is expressed in caudal (zeige CAD Antikörper) ganglionic eminence-derived disinhibitory interneurons in addition to excitatory neurons

  2. Pharmological manipulation by clobazam, a common anticonvulsant with preferential affinity for the GABRA2 (zeige GABRA2 Antikörper) receptor, revealed dose-dependent protection against hyperthermia-induced seizures in Scn1a+/- mice. These findings support Gabra2 (zeige GABRA2 Antikörper) as a genetic modifier of the Scn1a+/- mouse model of Dravet syndrome.

  3. In this study, we characterized the behavior of heterozygous mice expressing the SCN1A R1648H mutation (Scn1a(RH/+)) and the effect of stress on spontaneous and induced seizures. We also examined the effect of the R1648H mutation on the hypothalamic-pituitary-adrenal (HPA (zeige HPSE Antikörper)) axis response.

  4. findings establish an unexpected role for Nav1.1 channels in regulating the excitability of sensory nerve fibres that mediate mechanical pain

  5. Deletion of Nav1.1 channels selectively impairs excitability of GABAergic interneurons

  6. Results show Nav1.1 haploinsufficiency in excitatory neurons has an ameliorating effect on the pathology of Dravet syndrome.

  7. These results establish a direct role for SCN1A in the regulation of sleep

  8. Loss of NaV1.1 channels in forebrain GABAergic neurons is both necessary and sufficient to cause epilepsy and premature death in Dravet syndrome.

  9. mice with Scn1a haploinsufficiency exhibit hyperactivity, stereotyped behaviours, social interaction deficits and impaired context-dependent spatial memory; results demonstrate a critical role for Na(V)1.1 channels in neuropsychiatric functions and provide a potential therapeutic strategy for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome

  10. These results demonstrate increased expression levels of Nav1.7 (zeige SCN9A Antikörper), Nav1.8 (zeige SCN10A Antikörper), and perhaps Nav1.1 in the dorsal root ganglia in mice with a heterozygous mutation of the Nf1 (zeige NF1 Antikörper) gene

Human Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Interaktionspartner

  1. The results further substantiate the contribution of SCN1A in response and therapy optimization with PHT monotherapy.

  2. Rather than a single common gene/variant modifying clinical outcome in SCN1A-related epilepsies, our results point to the cumulative effect of rare variants with little to no measurable phenotypic effect (i.e., typical genetic background) unless present in combination with a disease-causing truncation mutation in SCN1A.

  3. genetic variants in 3'UTR (zeige UTS2R Antikörper) of SCN1A

  4. Among these transmissions were two likely disease-causing mutations: an SCN1A mutation transmitted to an SUDC proband and her sibling with Dravet syndrome, as well as an SLC6A1 (zeige SLC6A1 Antikörper) mutation in a proband with epileptic encephalopathy.

  5. study presents a phenotype-genotype correlation for SCN1A; described a distinct SCN1A phenotype, early infantile SCN1A encephalopathy, which is readily distinguishable from the Dravet syndrome and genetic epilepsy with febrile seizures plus

  6. This study demonstrated that early-life prolonged FSs have a profound long-term impact on neuronal function and adult seizure phenotypes in a mouse model of human SCN1A dysfunction.

  7. this study showed that SCN1A testing be considered in all individuals with febrile seizures or Dravet syndrome , as well as in familial cases consistent with febrile seizures.

  8. This study found significant differences in the distribution of truncating and missense variants across the SCN1A sequence among healthy individuals, patients with Dravet syndrome.

  9. SCN1A mutations may alter axonal function, causing motor neuropathy/neuronopathy. This may contribute to gait disturbance and orthopedic misalignment, which is characteristic of patients with Dravet syndrome.

  10. The association study indicated that age at first seizure and frameshift mutations of SCN1A were associated with Dravet syndrome.

Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A) Antigen-Profil

Protein Überblick

The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.

Genbezeichner und Symbole assoziert mit SCN1A

  • sodium channel, voltage-gated, type I, alpha subunit (SCN1A) Antikörper
  • sodium channel, voltage-gated, type IX, alpha subunit (SCN9A) Antikörper
  • sodium channel, voltage-gated, type I, alpha (Scn1a) Antikörper
  • B230332M13 Antikörper
  • EIEE6 Antikörper
  • FEB3 Antikörper
  • FEB3A Antikörper
  • FHM3 Antikörper
  • GEFSP2 Antikörper
  • HBSCI Antikörper
  • NAC1 Antikörper
  • Nav1.1 Antikörper
  • SCN1 Antikörper
  • SCN1A Antikörper
  • SCN9A Antikörper
  • SMEI Antikörper

Bezeichner auf Proteinebene für SCN1A

sodium channel, voltage-gated, type IX, alpha subunit , voltage-gated sodium channel I , sodium channel, voltage-gated, type I, alpha subunit , sodium channel protein brain I subunit alpha , sodium channel protein type 1 subunit alpha , sodium channel protein type I subunit alpha , sodium channel protein, brain I subunit alpha , sodium channel voltage-gated type I alpha polypeptide , sodium channel, voltage-gated, type 1, alpha polypeptide , sodium channel, voltage-gated, type I, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.1 , sodium channel protein, brain I alpha subunit , sodium channel voltage gated type 1 alpha subunit , sodium channel voltage-gated type I alpha

GENE ID SPEZIES
100052059 Equus caballus
395946 Gallus gallus
20265 Mus musculus
81574 Rattus norvegicus
6323 Homo sapiens
478775 Canis lupus familiaris
529590 Bos taurus
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