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Sodium Channel, Nonvoltage-Gated 1, gamma Proteine (SCNN1G)

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. Zusätzlich bieten wir Ihnen Sodium Channel, Nonvoltage-Gated 1, gamma Antikörper (93) und Sodium Channel, Nonvoltage-Gated 1, gamma Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SCNN1G 6340 P51170
SCNN1G 20278 Q9WU39
Ratte SCNN1G SCNN1G 24768 P37091
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 56 bis 61 Tage
5.753,97 €
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HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
664,76 €
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SCNN1G Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine)
,

Weitere Proteine zu Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G) Interaktionspartnern

Xenopus laevis Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G) Interaktionspartner

  1. Plasmin (zeige PLG Proteine) in nephrotic urine activates the epithelial sodium channel

Human Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G) Interaktionspartner

  1. hENaC incorporating the Liddle-mutated beta-subunit lacks one or more PKC phosphorylation sites, thereby significantly reducing the inhibitory effect of PKC on Na(+) channel activity, whereas hENaC incorporating Liddle-mutated gamma-subunits remains as susceptible to PKC as wild-type hENaC.

  2. deltabetagamma-ENaC (zeige SCNN1A Proteine) is inhibited by CFTR (zeige CFTR Proteine) but activated by cyclic AMP (zeige APRT Proteine).

  3. One nonsynonymous amino acid variants in SCNN1G in nonwhite Cystic fibrosis (zeige S100A8 Proteine) patients with non-diagnostic CFTR (zeige CFTR Proteine) genotypes was identified.

  4. Both vascular smooth muscle cell and bronchial gamma-ENaC downregulation may explain pulmonary fluid disturbances and participate in pulmonary edema pathogenesis.

  5. The transcriptional expression of alpha, beta, and gamma subunits of ENaC (zeige SCNN1A Proteine) was elevated in nasal polyp compared to nasal mucosa

  6. Suggest that SCNN1G gene has important roles in blood pressure regulation in the Han Chinese population.

  7. SCNN1A and SCNN1G SNPs may contribute to blood pressure changes over time in the Han Chinese population.

  8. Data indicate that urokinase-type plasminogen activator (uPA (zeige PLAU Proteine)) activates epithelial sodium channel, gamma subunit (ENaC gamma) through catalytic activity-dependent proteolytic modification.

  9. High serum leptin (zeige LEP Proteine) may reduce endometrial receptivity by activating the STAT3 (zeige STAT3 Proteine) signal pathway and down-regulating gamma-ENaC expression in the endometrium.

  10. human kidney gammaENaC is subject to proteolytic cleavage, yielding fragments compatible with furin (zeige FURIN Proteine) cleavage, and proteinuria is associated with cleavage at the putative prostasin (zeige PRSS8 Proteine)/kallikrein (zeige KLK4 Proteine) site and removal of the inhibitory tract within gammaENaC

Mouse (Murine) Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G) Interaktionspartner

  1. ENaC (zeige SCNN1A Proteine) and ROMK (zeige KCNJ1 Proteine) channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4 (zeige WNK4 Proteine)(PHAII)-induced inhibition of ENaC (zeige SCNN1A Proteine) and ROMK (zeige KCNJ1 Proteine) may contribute to the suppression of K(+) secretion in the tubules.

  2. Mouse cells conditionally overexpressing gamma ENAC had enhanced apical Na(+) entry increased the basolateral cell surface expression of Na,K-ATPase (zeige ATP1A1 Proteine) by inhibiting p38 (zeige CRK Proteine) kinase-mediated endocytosis of Na,K-ATPase (zeige ATP1A1 Proteine).

  3. Data indicate that insulin receptor (InsR (zeige INSR Proteine)) is important for epithelial sodium channel (ENaC (zeige SCNN1A Proteine)) activity.

  4. These data suggest that adenylyl cyclase VI mediates vasopressin (zeige AVP Proteine)-stimulated ENaC (zeige SCNN1A Proteine) activity in the kidney.

  5. Cys (zeige DNAJC5 Proteine) substitutions at sites in the wrist domains of the beta and gamma subunits alter the Na+ self-inhibition response.

  6. ENaC (zeige SCNN1A Proteine) is not a passive passenger in regulated epithelial vesicle trafficking, but plays a role in establishing and maintaining the pool of vesicles that respond to cAMP stimulation.

  7. The reactive intermediates formed during and after exposure to chlorine activated ERK1/2 in alveolar epithelial cells, leading to decreased ENaC (zeige SCNN1A Proteine) concentrations and activity.

  8. TMPRSS4 (zeige TMPRSS4 Proteine) primarily activates ENaC (zeige SCNN1A Proteine) by cleaving basic residues within the tract gammaK173-K186 distal to the furin (zeige FURIN Proteine) cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit.

  9. estrogen regulates expression and function of epithelial sodium channel gamma in osteoblasts

  10. Il-6 (zeige IL6 Proteine) activates ENaC-gamma channels in cortical collecting duct cells.

Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G) Protein Überblick

Protein Überblick

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome.

Genbezeichner und Symbole assoziert mit SCNN1G

  • sodium channel, nonvoltage-gated 1, gamma (SCNN1G)
  • sodium channel, non-voltage-gated 1, gamma subunit (SCNN1G)
  • sodium channel, nonvoltage-gated 1, gamma (scnn1g)
  • sodium channel, nonvoltage-gated 1 gamma (Scnn1g)
  • sodium channel, nonvoltage-gated 1, gamma (Scnn1g)
  • BESC3 Protein
  • ENaC Protein
  • ENaCg Protein
  • ENaCgamma Protein
  • GAMMA-ENAC Protein
  • MGC81424 Protein
  • PHA1 Protein
  • SCNEG Protein
  • SCNN1G Protein
  • [g]ENaC Protein

Bezeichner auf Proteinebene für SCNN1G

sodium channel, nonvoltage-gated 1, gamma , amiloride-sensitive sodium channel subunit gamma , epithelium sodium channel gamma subunit , amiloride sensitive epithelial sodium channel gamma subunit , ENaC gamma subunit , amiloride-sensitive epithelial sodium channel gamma subunit , amiloride-sensitive sodium channel gamma-subunit , epithelial Na(+) channel subunit gamma , gamma-ENaC , gamma-NaCH , nonvoltage-gated sodium channel 1 subunit gamma , SCNEG , amiloride-sensitive sodium channel gamma subunit , epithelial sodium channel ENaC gamma subunit , epithelial sodium channel, gamma subunit , ENaC gamma , Sodium channel nonvoltage-gated 1 gamma (epithelial) , Sodium channel, nonvoltage-gated 1, gamma (epithelial) , amiloride sensitive sodium channel gamma1 subunit , epithelial sodium channel gamma subunit , sodium channel, nonvoltage-gated, type I, gamma

GENE ID SPEZIES
416579 Gallus gallus
467925 Pan troglodytes
489973 Canis lupus familiaris
617802 Bos taurus
699971 Macaca mulatta
779366 Xenopus laevis
100170326 Ovis aries
100460323 Pongo abelii
6340 Homo sapiens
100008850 Oryctolagus cuniculus
20278 Mus musculus
24768 Rattus norvegicus
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