anti-Sirtuin 6 (SIRT6) Antikörper

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 6 Proteine (20) und Sirtuin 6 Kits (18) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SIRT6 50721 P59941
SIRT6 51548 Q8N6T7
SIRT6 299638  
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Top anti-Sirtuin 6 Antikörper auf antikoerper-online.de

Showing 10 out of 218 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert ChIP, IP, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (fro), IHC (p), IP, WB Detection of SIRT6 in MEF lysate using ABIN250952. Western Blot: SIRT6 Antibody [ABIN250952] - WB analysis of SIRT6 in NIH/3T3 cell lysate. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Human Kaninchen Unkonjugiert IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT6 Antibody (C-term) (ABIN390181) in mouse stomach tissue lysates (35 µg/lane). SIRT6 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p) 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Mouse Cardiac Muscle Tissue Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert ICC, IF, WB Detection of SIRT6 in HeLa whole cell lysate using ABIN250956. Immunocytochemistry/Immunofluorescence: SIRT6 Antibody [ABIN250956] - SIRT6 antibody was tested in Hela cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Human Kaninchen Unkonjugiert WB SIRT6 antibody tested by Western blot. HeLa cells nuclear extract (25 μg) probed with SIRT6 antibody (1:1,000). 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$495.83
Details
Human Kaninchen Biotin IHC (p), WB   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB   100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$328.90
Details

SIRT6 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Sirtuin 6 Antikörper

  1. Human Polyclonal SIRT6 Primary Antibody für ICC, IF - ABIN250952 : Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012 (PubMed)
    Show all 11 Pubmed References

  2. Human Polyclonal SIRT6 Primary Antibody für IHC - ABIN967032 : Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal SIRT6 Primary Antibody für IHC - ABIN967033 : Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: A quantitative atlas of mitotic phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal SIRT6 Primary Antibody für ELISA - ABIN526804 : Grimley, Polyakova, Vamathevan, McKenary, Hayes, Patel, Smith, Bridges, Fosberry, Bhardwaja, Mouzon, Chung, Barrett, Richmond, Modha, Solari: Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NF?B responses. in PLoS ONE 2012 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal SIRT6 Primary Antibody für IHC (p), WB - ABIN390181 : Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014 (PubMed)
    Show all 2 Pubmed References

  6. Cow (Bovine) Polyclonal SIRT6 Primary Antibody für ChIP, IP - ABIN2779624 : Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal SIRT6 Primary Antibody für WB - ABIN2668661 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)

  8. Human Polyclonal SIRT6 Primary Antibody für IF (p), IHC (p) - ABIN712481 : Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014 (PubMed)

  9. Human Polyclonal SIRT6 Primary Antibody für ICC, IF - ABIN250956 : Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012 (PubMed)

Weitere Antikörper gegen Sirtuin 6 Interaktionspartner

Mouse (Murine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. Sirt6 inhibits Notch1 (zeige NOTCH1 Antikörper) and Notch4 (zeige NOTCH4 Antikörper) transcription by deacetylating histone H3K9.

  2. Sirt6 is downregulated in induced pluripotent stem cells from old mice.

  3. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (zeige PARP1 Antikörper)) to DNA break sites and for efficient repair of double-strand break.

  4. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

  5. These findings reveal a crucial role of SIRT6 in adipogenesis and provide potential therapeutic targets for obesity.

  6. Global and endothelium-specific SIRT6 knockout mice exhibited impaired endothelium-dependent vasorelaxation. Moreover, SIRT6(+/-) haploinsufficient mice fed a high-fat diet (HFD) also displayed impaired endothelium-dependent vasorelaxation. Importantly, SIRT6(+/-); ApoE(-/-) mice after HFD feeding had exacerbated atherosclerotic lesion development, concurrent with increased expression of proinflammatory cytokine VCAM-1.

  7. these data provide compelling evidence that Sirt6 is important for podocyte homeostasis and maintenance of glomerular function

  8. The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (zeige INS Antikörper) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.

  9. Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.

  10. Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (zeige NFKB1 Antikörper)) and endogenous production of interleukin-6 (zeige IL6 Antikörper), which led to STAT3 (zeige STAT3 Antikörper) activation and the positive feedback circuits for NF-kappaB (zeige NFKB1 Antikörper) stimulation; this cross talk expedited an M1 polarization

Human Sirtuin 6 (SIRT6) Interaktionspartner

  1. Sirt6 inhibits Notch1 (zeige NOTCH1 Antikörper) and Notch4 (zeige NOTCH4 Antikörper) transcription by deacetylating histone H3K9.

  2. These data provide the first evidence of the Egt ability to interfere with endothelial senescence linked to hyperglycaemia through the regulation of SIRT1 (zeige SIRT1 Antikörper) and SIRT6 signaling, thus further strengthening the already assessed role of these two histone deacetylases in type 2 diabetes.

  3. Study shows that SIRT6 protein levels are lower in patients with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM) and implies that SIRT6 may take play in development T2DM by altering the expression of genes involved in glucose metabolism through histone modification rather than its role in DNA repair.

  4. Low SIRT6 expression is associated with bone marrow metastasis in neuroblastoma (zeige ARHGEF16 Antikörper).

  5. SIRT6 overexpression suppresses PI3K (zeige PIK3CA Antikörper) signaling.

  6. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (zeige PARP1 Antikörper)) to DNA break sites and for efficient repair of double-strand break.

  7. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

  8. Loss- and gain-of-SIRT6 function studies in cultured human endothelial cells (ECs) showed that SIRT6 attenuated monocyte adhesion to ECs.

  9. The expression of SIRT6 was reduced during cellular senescence, whereas enforced SIRT6 expression promoted cell proliferation and antagonized cellular senescence.Furthermore, SIRT6 directly interacted with p27 (zeige PAK2 Antikörper). Finally, SIRT6 markedly rescued senescence induced by p27 (zeige PAK2 Antikörper).

  10. Previously unknown reciprocal influence of SIRT6 and HK2 (zeige HK2 Antikörper) in regulating autophagy driven monocyte differentiation.

Cow (Bovine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (zeige MAS1 Antikörper)) and management in beef cattle breeding programs.

Sirtuin 6 (SIRT6) Antigen-Profil

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit anti-Sirtuin 6 (SIRT6) Antikörper

  • sirtuin 6 (Sirt6) Antikörper
  • sirtuin 6 (SIRT6) Antikörper
  • sirtuin 6 S homeolog (sirt6.S) Antikörper
  • sirtuin 6 (sirt6) Antikörper
  • 2810449N18Rik Antikörper
  • AI043036 Antikörper
  • SIR2L6 Antikörper
  • zgc:86729 Antikörper

Bezeichner auf Proteinebene für anti-Sirtuin 6 (SIRT6) Antikörper

NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6 , sirtuin (silent mating type information regulation 2 homolog) 6

GENE ID SPEZIES
50721 Mus musculus
51548 Homo sapiens
299638 Rattus norvegicus
428332 Gallus gallus
535416 Bos taurus
100126274 Sus scrofa
444018 Xenopus laevis
485045 Canis lupus familiaris
100734667 Cavia porcellus
415161 Danio rerio
737026 Pan troglodytes
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