Single-Minded Homolog 2 (Drosophila) Proteine (SIM2)

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. Zusätzlich bieten wir Ihnen Single-Minded Homolog 2 (Drosophila) Antikörper (50) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIM2 6493 Q14190
SIM2 20465 Q61079
Ratte SIM2 SIM2 304071  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details

SIM2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Mouse (Murine)

Weitere Proteine zu Single-Minded Homolog 2 (Drosophila) (SIM2) Interaktionspartnern

Human Single-Minded Homolog 2 (Drosophila) (SIM2) Interaktionspartner

  1. Two genes, OR51E2 (zeige OR51E2 Proteine) and SIM2, and two miRNAs, miR (zeige MLXIP Proteine)-200c and miR (zeige MLXIP Proteine)-200b, showed significant association with prostate cancer.

  2. In SH-SY5Y cells, ethanol exposure increased Sim2 expression in a manner similar to that of cleaved caspase 3. PKA activation was required for this. Sim2 might be involved in activating caspase 3 and ethanol-induced apoptosis in SH-SY5Y cells.

  3. a single peptide containing multiple SIM2 epitopes can be used to induce both a CD4 (zeige CD4 Proteine) and CD8 (zeige CD8A Proteine) T cell response, providing a peptide-based vaccine formulation for potential use in immunotherapy of various cancers.

  4. Data showed that SIM2 was highly expressed in human glioma tumors and cell lines and its short form might increase the invasion of glioma cells through the alteration of epithelial-mesenchymal transition.

  5. Data suggest selected SIM1 (zeige SIM1 Proteine) variants exhibit poor dimerization with ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2 (zeige ARNT2 Proteine)) and anomalous intracellular localization; data were used to predict spot in SIM1 (zeige SIM1 Proteine)/SIM2 (residues 290-326) critical in function.

  6. miR (zeige MLXIP Proteine)-200a is downregulated in human glioma and inhibition of miR (zeige MLXIP Proteine)-200a caused upregulation of SIM2-s in T98G cells and promoted their motility.

  7. Altered expression of SIM2 and ETS2 (zeige ETS2 Proteine) could be one of the reasons for variable occurrence of different malignant conditions in Down syndrome.

  8. These results suggest an involvement of SIM2 in key traits of prostate tumor cell biology.

  9. Significantly lower frequency of SIM2 C-G haplotype (rs2073601-rs2073416) was noticed in individuals with Down syndrome (P value =0.01669) and their fathers (P value=0.01185)

  10. Genetic variants of SIM2 gene may not be associated with the susceptibility to congenital scoliosis and different clinical phenotypes of CS in Chinese Han population.

Mouse (Murine) Single-Minded Homolog 2 (Drosophila) (SIM2) Interaktionspartner

  1. Ethanol induced Sim2 expression in cerebral cortices of P7 Mice via the PKA pathway.

  2. Study provides evidence that SIM2 binds a specific set of enhancer elements thus explaining how SIM2 can regulate its gene network in neuronal features.

  3. Our results establish that SIM2 is a crucial regulator in controlling expression of intestinal AMPs (zeige ADSL Proteine)

  4. Sim2 prevents entry into the myogenic program by repressing MyoD (zeige MYOD1 Proteine) transcription during limb embryonic myogenesis.

  5. mammary gland involution is disrupted in Sim2s overexpression and STAT3 (zeige STAT3 Proteine)-mediated signaling and other pathways involved in the acute phase response are inhibited

  6. Differential activities of murine single minded 1 (SIM1 (zeige SIM1 Proteine)) and SIM2 on a hypoxic response element

  7. Sim2 mutants also develop congenital scoliosis, reflected by the unequal sizes of the left and right vertebrae and ribs. The spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity.

  8. Data show that premature accumulation of hyaluronan in Sim2 -/- animal palates suggests a regulatory role for Sim2 in hyaluronan synthesis and in the establishment of craniofacial architecture.

  9. Sim1 (zeige SIM1 Proteine) and Sim2 act along compensatory, but not hierarchical, pathways, suggesting that they play similar roles in vivo.

  10. Sim2 and Sim2s are isoforms that may play different roles during development or in tissue-specific effects on other protein-mediated pathways

Single-Minded Homolog 2 (Drosophila) (SIM2) Protein Überblick

Protein Überblick

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes

Genbezeichner und Symbole assoziert mit SIM2

  • single-minded family bHLH transcription factor 2 S homeolog (sim2.S)
  • single-minded family bHLH transcription factor 2 (sim2)
  • single-minded family bHLH transcription factor 2 (SIM2)
  • single-minded homolog 2 (Drosophila) (SIM2)
  • single-minded homolog 2 (Drosophila) (Sim2)
  • single-minded family bHLH transcription factor 2 (Sim2)
  • bHLHe15 Protein
  • HMC13F06 Protein
  • HMC29C01 Protein
  • SIM Protein
  • sim2-A Protein
  • xSim Protein
  • Xsim2 Protein

Bezeichner auf Proteinebene für SIM2

single-minded homolog 2 , class E basic helix-loop-helix protein 15 , single-minded homolog 2, short isoform , transcription factor SIM2 , single-minded (Drosophila) homolog 2 , SIM transcription factor , mSIM , single-minded 2

GENE ID SPEZIES
373634 Xenopus laevis
114450 Danio rerio
418515 Gallus gallus
6493 Homo sapiens
607987 Canis lupus familiaris
100337422 Bos taurus
20465 Mus musculus
304071 Rattus norvegicus
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