Signal Peptide Peptidase-Like 2B Proteine (SPPL2B)

SPPL2B encodes a member of the GXGD family of aspartic proteases. Zusätzlich bieten wir Ihnen SPPL2B Antikörper (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SPPL2B 56928 Q8TCT7
SPPL2B 73218 Q3TD49
Ratte SPPL2B SPPL2B 362828 Q5PQL3
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Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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SPPL2B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine) ,
,

Weitere Proteine zu Signal Peptide Peptidase-Like 2B (SPPL2B) Interaktionspartnern

Zebrafish Signal Peptide Peptidase-Like 2B (SPPL2B) Interaktionspartner

  1. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

Human Signal Peptide Peptidase-Like 2B (SPPL2B) Interaktionspartner

  1. TfR1 (zeige TFRC Proteine) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.

  2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (zeige ITM2B Proteine)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

  3. SPP, SPPL2a (zeige SPPL2A Proteine), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER.

  5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (zeige TNF Proteine) into the cytosol.

  6. SPPL2a (zeige SPPL2A Proteine) and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (zeige ITM2B Proteine) N-terminal fragment.

  7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (zeige TNF Proteine) and caused a relative increase of longer intracellular cleavage products.

Mouse (Murine) Signal Peptide Peptidase-Like 2B (SPPL2B) Interaktionspartner

  1. in vivo SPPL2a (zeige SPPL2A Proteine), but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (zeige CD74 Proteine) proteolysis in B and dendritic cells

SPPL2B Protein Überblick

Protein Überblick

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SPPL2B

  • signal peptide peptidase-like 2 (sppl2)
  • signal peptide peptidase-like 2B (sppl2b)
  • signal peptide peptidase like 2B (sppl2b)
  • signal peptide peptidase like 2B (SPPL2B)
  • signal peptide peptidase like 2B (Sppl2b)
  • signal peptide peptidase-like 2B (SPPL2B)
  • signal peptide peptidase-like 2B (Sppl2b)
  • 3110056O03Rik Protein
  • AW550292 Protein
  • IMP-4 Protein
  • IMP4 Protein
  • MGC147524 Protein
  • PSH4 Protein
  • PSL1 Protein
  • RGD1308556 Protein
  • SPPL2B Protein
  • wu:fc16e01 Protein
  • wu:fc85d12 Protein
  • zgc:136525 Protein

Bezeichner auf Proteinebene für SPPL2B

signal peptide peptidase-like 2B , signal peptide peptidase-like protein 2 , SPP-like 2B , protein SPP-like 2B , protein SPPL2b , intramembrane protease 4 , presenilin homologous protein 4 , presenilin-like protein 1

GENE ID SPEZIES
325540 Danio rerio
780336 Xenopus (Silurana) tropicalis
379574 Xenopus laevis
420056 Gallus gallus
56928 Homo sapiens
73218 Mus musculus
504285 Bos taurus
362828 Rattus norvegicus
Ausgewählte Anbieter für SPPL2B Proteine (SPPL2B)
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