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SESN2 encodes a member of the sestrin family of PA26-related proteins. Zusätzlich bieten wir Ihnen Sestrin 2 Antikörper (53) und Sestrin 2 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
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The results suggest that SESN2 increases degradation of HIF-1A (zeige HIF1A Proteine) via AMPK (zeige PRKAA1 Proteine)-PHD (zeige PDC Proteine) regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.
simple analysis of the reported "apo (zeige C9orf3 Proteine)"-Sestrin2 structure reveals the clear presence of prominent, unmodeled electron density in the leucine-binding pocket that exactly accommodates the leucine observed in the higher resolution structure.
Mass spectrometry analysis, western blot and surface plasmon resonance (SPR (zeige SPR Proteine)) of affinity purified sesn1 (zeige SESN1 Proteine) and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 (zeige SESN1 Proteine) and sesn2 have a predominant a-helical structure.
The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma
The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4 (zeige ATF4 Proteine).
Sesn2 has two subdomains. The N-terminal domain reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase (zeige TXNRD1 Proteine) motif, and the C-terminal domain interacts with GATOR2 and subsequently inhibits mTORC1.
SESN2-AMPK (zeige PRKAA1 Proteine) signaling could exert a protective effect against glucose deprivation-induced cell death and that this effect is mediated by restoration of mitochondrial function.
Sesn2 is a potential tumor suppressor in lung epithelial cells. The expression level of Sesn2 may serve as a prognostic marker for Chinese lung cancer patients in the clinic.
The findings suggested that a decreased expression of sestrin 2 is associated with an unfavorable prognosis, which suggests that it is a novel and crucial predictor for colorectal cancer metastasis.
an AMPK (zeige PRKAA1 Proteine)-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported.
SESN2 suppressed ER stress-mediated apoptosis. SESN2 attenuated hepatic injury in mice.
Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK (zeige PRKAA1 Proteine) activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults.
p53 (zeige TP53 Proteine)-dependent coordination with SESN2 regulates AMPK (zeige PRKAA1 Proteine) and mTORC1 signaling and controls parturition timing
Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin (zeige INS Proteine) signaling through the activation of AMPK (zeige PRKAA1 Proteine) signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin (zeige INS Proteine) sensitivity and glucose metabolism via AMPK (zeige PRKAA1 Proteine)-dependent autophagic activation.
Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1 (zeige HMOX1 Proteine)/Sesn2 signaling pathway.
suggest that TLR-mediated Sesn2 induction is dependent on AP-1 (zeige JUN Proteine), Nrf2 (zeige NFE2L2 Proteine), and the inhibition of ubiquitin-mediated degradation of Sesn2 and might protect cells against endotoxin toxicity
Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (zeige PRKAA1 Proteine) or TSC2. Surprisingly, when coexpressed with a GTP (zeige AK3 Proteine)-bound constitutively active form of RagB (zeige RRAGB Proteine) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
Sestrin2 plays an important role in cardioprotection against I/R injury, serving as an LKB1 (zeige STK11 Proteine)-AMPK (zeige PRKAA1 Proteine) scaffold to initiate AMPK (zeige PRKAA1 Proteine) activation during ischemic insults
Data indicate that sestrin2 expression is upregulated by dopamine D2 receptor (zeige DRD2 Proteine).
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
hypoxia induced gene 95
, sestrin 2