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SESN2 encodes a member of the sestrin family of PA26-related proteins. Zusätzlich bieten wir Ihnen Sestrin 2 Antikörper (53) und Sestrin 2 Kits (16) und viele weitere Produktgruppen zu diesem Protein an.
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The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma
The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4 (zeige ATF4 Proteine).
Sesn2 has two subdomains. The N-terminal domain reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase (zeige TXNRD1 Proteine) motif, and the C-terminal domain interacts with GATOR2 and subsequently inhibits mTORC1.
SESN2-AMPK (zeige PRKAA1 Proteine) signaling could exert a protective effect against glucose deprivation-induced cell death and that this effect is mediated by restoration of mitochondrial function.
Sesn2 is a potential tumor suppressor in lung epithelial cells. The expression level of Sesn2 may serve as a prognostic marker for Chinese lung cancer patients in the clinic.
The findings suggested that a decreased expression of sestrin 2 is associated with an unfavorable prognosis, which suggests that it is a novel and crucial predictor for colorectal cancer metastasis.
an AMPK (zeige PRKAA1 Proteine)-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported.
GAA (zeige GAA Proteine) promotes FoxO3 (zeige FOXO3 Proteine) nuclear translocation and binding to the SESN2 enhancer.
Data indicate that inactivation of Sestrin 2 (Sesn2) or nuclear factor erythroid 2-related factor 2 (Nrf2 (zeige NFE2L2 Proteine)) induced reactive oxygen species-mediated proteasomal inhibition and platelet-derived growth factor receptor beta (zeige PDGFRB Proteine) (Pdgfrbeta) accumulation.
Sesn2 is oncogenic in skin squamous cell carcinoma and melanoma.
Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin (zeige INS Proteine) signaling through the activation of AMPK (zeige PRKAA1 Proteine) signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin (zeige INS Proteine) sensitivity and glucose metabolism via AMPK (zeige PRKAA1 Proteine)-dependent autophagic activation.
Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1 (zeige HMOX1 Proteine)/Sesn2 signaling pathway.
suggest that TLR-mediated Sesn2 induction is dependent on AP-1 (zeige JUN Proteine), Nrf2 (zeige NFE2L2 Proteine), and the inhibition of ubiquitin-mediated degradation of Sesn2 and might protect cells against endotoxin toxicity
Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (zeige PRKAA1 Proteine) or TSC2. Surprisingly, when coexpressed with a GTP (zeige AK3 Proteine)-bound constitutively active form of RagB (zeige RRAGB Proteine) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
Sestrin2 plays an important role in cardioprotection against I/R injury, serving as an LKB1 (zeige STK11 Proteine)-AMPK (zeige PRKAA1 Proteine) scaffold to initiate AMPK (zeige PRKAA1 Proteine) activation during ischemic insults
Data indicate that sestrin2 expression is upregulated by dopamine D2 receptor (zeige DRD2 Proteine).
this study identifies ULK1 as a new p62 Ser403 kinase and establishes Sestrin2 as a promoter of ULK1-mediated p62 phosphorylation.
Sesn2 controls reactive oxygen species-dependent neuropathic pain signaling after peripheral nerve injury.
results imply that SESN2 could serve as both a biomarker and as a drug target in the clinical management of COPD (zeige ARCN1 Proteine)
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
, hypoxia induced gene 95