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SEPT6 is a member of the septin family of GTPases. Zusätzlich bieten wir Ihnen Septin 6 Antikörper (74) und Septin 6 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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It has been found that Sep2 is uniquely required for follicle cell encapsulation of female germline cysts, and that Sep2 and Sep5 are redundant for follicle cell proliferation.
Results show that Sep2 Sep5 double mutants have an early pupal lethal phenotype and lack imaginal discs, suggesting that these genes have redundant functions during imaginal cell proliferation.
Sept6 is first expressed in the notochord and then in nearly all of the ciliary organs, including Kupffer's vesicle (KV), the pronephros, eye, olfactory bulb, and neural tube. Knockdown of sept6 results in reduced numbers and length of cilia in KV.
SUMOylation of human septins is critical for septin filament bundling and cytokinesis.
MiR (zeige MLXIP Proteine)-223-3p might target gene SEPT6 and promoted the biological behavior of prostate cancer.
Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis
The SEPT6 provides the directional guidance cues necessary for polarizing the epithelial microtubule network.
Data show that Septins of the SEPT6 group preferentially interacted with septins of the SEPT2 (zeige SEPT2 Proteine) group, SEPT3 (zeige SEPT3 Proteine) group and SEPT7 (zeige SEPT7 Proteine) group.
MLL (zeige MLL Proteine)-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia
Molecular analysis using rtPCR followed by sequencing confirmed the expression of an MLL (zeige MLL Proteine)-SEPT6 fusion transcript with a novel sequence.
septin 2 (zeige SEPT2 Proteine), 6, and 7 complexes make up polymerized filaments
These results indicate that the host proteins hnRNP A1 (zeige HNRNPA1 Proteine) and septin 6 play important roles in the replication of HCV through RNA-protein and protein-protein interactions.
crystal structures of the human SEPT2 (zeige SEPT2 Proteine) G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 (zeige SEPT7 Proteine) complex
Data suggest a regulatory role for septin 6 in long-term hematopoietic stem cells (HSCs) function and lymphoid lineage differentiation.
Sept6 did not alter the phenotype of myeloproliferative disease induced by MLL (zeige MLL Proteine)-SEPT6, thus suggesting that Sept6 does not function as a tumor suppressor.
Significant level of SEPT6 expression was found in heart in a developmentally regulated fashion.
Data demonstrate that the septin cytoskeleton is an integral component of the myelin sheath, and protein components such as septin 6 interact with distinct myelin constituents such as MAL.
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.
, myosin LC
, septin 2
, septin 11
, septin 6