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Filament-forming cytoskeletal GTPase. Zusätzlich bieten wir Ihnen Septin 2 Proteine (14) und Septin 2 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SEPT2 Primary Antibody für ICC, IF - ABIN4352727
Volceanov, Herbst, Biniossek, Schilling, Haller, Nölke, Subbarayal, Rudel, Zieger, Häcker: Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. in mBio 2014
Show all 2 Pubmed References
Human Polyclonal SEPT2 Primary Antibody für ELISA, WB - ABIN451620
Kremer, Adang, Macara: Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. in Cell 2007
Depletion of septin 2 reduces Drp1 (zeige CRMP1 Antikörper) recruitment to mitochondria and results in hyperfused mitochondria and delayed FCCP-induced fission.
septins protect ErbB2 (zeige ERBB2 Antikörper) from ubiquitylation, endocytosis and lysosomal degradation. Septin (zeige SEPT6 Antikörper) oligomerization regulates persistent expression of ErbB2/HER2 (zeige ERBB2 Antikörper) in gastric cancer cells.
The results showed that SEPT2 has an oncogenic function through accelerated cell proliferation and invasion in biliary tract cancers, and is negatively regulated by miR (zeige MLXIP Antikörper)-140-5p.
From the nucleotide-free structure some interesting conclusions about the nucleotide binding properties of Cdc11 can be drawn; especially when aligning the structure with the structure of GDP bound Sept2
These results suggest that SEPTIN2-mediated cytoskeletal rearrangement and STATHMIN (zeige STMN1 Antikörper)-mediated differentiation may contribute to changes in cell morphology and differentiation of H/RS cells with CD99 (zeige CD99 Antikörper) upregulation in Hodgkin lymphoma.
Data indicate that forchlorfenuron (FCF) exhibits differential binding preference for septins SEPT2 and SEPT3 (zeige SEPT3 Antikörper).
Authors report here that the septins SEPT2, -9, -11, and probably -7 form fibrillar structures around the chlamydial inclusion.
Suggest PPAR-gamma (zeige PPARG Antikörper) activation down-regulates hepatocellular carcinoma cell SEPT2 levels to prevent tumor growth.
SEPT2 forms a 1:1:1 complex with SEPT7 (zeige SEPT7 Antikörper) and SEPT9 (zeige SEPT9 Antikörper).
The results shown in study support the hypothesis that single Septin 2, when present in excess (zeige RCC1 Antikörper) or with unbalanced stoichiometries, may be unstable and assemble into amyloid-like structures.
Results indicate a stimulatory role of septin-2 and the dynamic reorganization of septin (zeige SEPT6 Antikörper) oligomers in exocytosis.
findings show SEPT2 is part of a diffusion barrier at the base of the ciliary membrane and is essential for retaining receptor-signaling pathways in the primary cilium
Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin (zeige ADD2 Antikörper), septin 2, and sh3p8 (zeige SH3GL1 Antikörper) as putative paranodal proteins.
Significant level of SEPT2 expression was found in heart in a developmentally regulated fashion.
p85 (zeige ECM1 Antikörper) is thus involved in the spatial control of cytosolic division through regulation of Cdc42 (zeige CDC42 Antikörper) and septin 2, in a PI3K-activity independent manner.
study identified control of septin (zeige SEPT6 Antikörper) localization by the planar cell polarity (PCP (zeige PRCP Antikörper)) protein Fritz (zeige WDPCP Antikörper) as a crucial control point for both collective cell movement and ciliogenesis in embryos
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity).
, septin 2
, neural precursor cell expressed developmentally down-regulated protein 5
, neural precursor cell expressed, developmentally down-regulated 5
, neural precursor cell expressed, developmentally down-regulated gene 5
, vascular endothelial cell specific protein 11
, septin A