Septin 12 Proteine (Sep12)

Sep12 encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Zusätzlich bieten wir Ihnen Septin 12 Antikörper (31) und Septin 12 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Sep12 124404 Q8IYM1
Maus Sep12 Sep12 71089  
Ratte Sep12 Sep12 363542 Q4V8G5
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Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.844,29 €
Details

Sep12 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu Septin 12 (Sep12) Interaktionspartnern

Human Septin 12 (Sep12) Interaktionspartner

  1. In mature human spermatozoa, SEPT12 and NDC1 are majorly colocalized in the centrosome regions; however, NDC1 is only slightly co-expressed with SEPT12 at the annulus of the sperm tail.

  2. results demonstrate the molecular architecture of SEPT12 filaments at the sperm annulus, their mechanical support of sperm motility, and their correlation with male infertility.

  3. we discovered that the SEPTIN12-microtubule complexes are critical for sperm formation during spermiogenesis

  4. SEPTIN12 genetic variants confer susceptibility to teratozoospermia

  5. Eight coding single-nucleotide polymorphisms in SEPTIN12 were detected in the patients with Sertoli cell-only syndrome. Analysis of the results suggest that SEPTIN12 might play a critical role in human spermatogenesis.

  6. SEPT12 mutations cause male infertility with defective sperm annulus and disrupt sperm structural integrity

  7. The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest

  8. While SEPT12 formed filamentous structures at interphase, it was localized to the central spindle and to midbody during anaphase and cytokinesis, respectively.

  9. Decreases in SEPTIN12 expression is associated with male infertility.

Mouse (Murine) Septin 12 (Sep12) Interaktionspartner

  1. Data suggest that SEPT12 phosphorylation inhibits septin (zeige SEPT6 Proteine) ring assembly during annulus biogenesis.

  2. In mice sperm with mutated SEPT12, NDC1 dispersed around the manchette region of the sperm head and annulus, compared with concentrating at the sperm neck of wild-type sperm.

  3. results demonstrate the molecular architecture of SEPT12 filaments at the sperm annulus, their mechanical support of sperm motility, and their correlation with male infertility.

  4. Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF (zeige SCN5A Proteine) and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa

Septin 12 (Sep12) Protein Überblick

Protein Überblick

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit Septin 12 Proteine (Sep12)

  • septin 12 (sept12)
  • septin 12 (SEPT12)
  • septin 12 (LOC100339863)
  • septin 12 (Sept12)
  • 1700028G04Rik Protein
  • 4933413B09Rik Protein
  • fe23c11 Protein
  • MGC68931 Protein
  • Septin12 Protein
  • si:dkey-23a11.2 Protein
  • SPGF10 Protein
  • wu:fe23c11 Protein

Bezeichner auf Proteinebene für Septin 12 Proteine (Sep12)

septin 12 , septin-12

GENE ID SPEZIES
379651 Xenopus laevis
748303 Pan troglodytes
100339863 Oryctolagus cuniculus
564600 Danio rerio
124404 Homo sapiens
100688231 Canis lupus familiaris
618676 Bos taurus
71089 Mus musculus
363542 Rattus norvegicus
416408 Gallus gallus
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