Sclerostin Proteine (SOST)

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Zusätzlich bieten wir Ihnen Sclerostin Antikörper (128) und Sclerostin Kits (57) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Showing 10 out of 18 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Human His tag 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details
HOST_Human Cells Ratte His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_HEK-293 Cells Human Biotin,His tag Biotinylated Human SOST on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 200 μg Anmelden zum Anzeigen 6 bis 8 Tage
1.457,14 €
Details
HOST_Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
523,81 €
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HOST_Human Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
285,71 €
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HOST_Mammalian Cells Maus His tag   10 μg Anmelden zum Anzeigen 8 bis 9 Tage
231,00 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.323,97 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.334,45 €
Details

SOST Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , ,
, ,
Mouse (Murine) , ,
,
Rat (Rattus) ,

Am meisten referenzierte Sclerostin Proteine

  1. Human Sclerostin Protein expressed in Human Cells - ABIN2003109 : Brunkow, Gardner, Van Ness, Paeper, Kovacevich, Proll, Skonier, Zhao, Sabo, Fu, Alisch, Gillett, Colbert, Tacconi, Galas, Hamersma, Beighton, Mulligan: Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. in American journal of human genetics 2001 (PubMed)
    Zeige alle 5 Referenzen für 2003109

  2. Rat (Rattus) Sclerostin Protein expressed in Human Cells - ABIN2009022 : Balemans, Ebeling, Patel, Van Hul, Olson, Dioszegi, Lacza, Wuyts, Van Den Ende, Willems, Paes-Alves, Hill, Bueno, Ramos, Tacconi, Dikkers, Stratakis, Lindpaintner, Vickery, Foernzler, Van Hul: Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). in Human molecular genetics 2001 (PubMed)
    Zeige alle 5 Referenzen für 2009022

Weitere Proteine zu Sclerostin (SOST) Interaktionspartnern

Human Sclerostin (SOST) Interaktionspartner

  1. In chronic kidney disease, serum levels of the Wnt (zeige WNT2 Proteine) inhibitors DKK1 (zeige DKK1 Proteine) and sclerostin are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin, as opposed to DKK1 (zeige DKK1 Proteine), may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD (zeige DPEP1 Proteine)), particularly in dialysis patients.

  2. Vitamin D receptor (zeige VDR Proteine) agonism by paricalcitol causes a moderate increase in serum sclerostin in CKD patients, and this effect is modified by circulating pentosidine levels.

  3. SOST is frequently expressed in skeletal bone- and cartilage-forming tumors. The strong spatial correlation with bone formation and the in vitro expression patterns are in line with the known functions of SOST in nonneoplastic bone, as a feedback inhibitor on osteogenic differentiation.

  4. Intermittent compressive stress regulates Notch (zeige NOTCH1 Proteine) receptor and target gene expression via the TGF-beta (zeige TGFB1 Proteine) signaling pathway. Notch (zeige NOTCH1 Proteine) signaling participates in TGF-beta (zeige TGFB1 Proteine)-induced sclerostin expression in periodontal ligament cells.

  5. Dickkopf-1 (zeige DKK1 Proteine) and sclerostin were never correlated with each other or with bone turnover markers patients with Paget's disease of bone. Sclerostin was positively correlated with age.

  6. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  7. Circulating sclerostin and Dickkopf-1 levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women.

  8. SOST is expressed in the aorta and downregulated in human aortic aneurysms and atheros (zeige WNT2 Proteine)clerosis, possibly because of epigenetic silencing.

  9. The level of sclerostin was higher in the female obstructive sleep apnea (OSA) patients than that in female controls. Further, in OSA women with cardiovascular comorbidities, sclerostin was higher than in women without such comorbidities. In men, there were no differences in the serum sclerostin level between the OSA and control subjects, nor was there any relationship with cardiovascular diseases.

  10. Knockdown of SOST in MG-63 cells increases osteogenesis and ratio of OPG/RANKL (zeige TNFSF11 Proteine) in vitro

Mouse (Murine) Sclerostin (SOST) Interaktionspartner

  1. In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.

  2. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  3. Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (zeige WNT2 Proteine) signaling pathway inhibition.

  4. Analysis of SOST expression using large minigenes reveals the MEF2C (zeige MEF2C Proteine) binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D3 or TGFbeta1 (zeige TGFB1 Proteine) responsiveness.

  5. removal of sclerostin appears to modestly protect the alveolar bone from resorption in this experimental setting

  6. chronic TNFalpha (tumor necrosis factor alpha (zeige TNF Proteine))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.

  7. Data show that the phenotype of Notch (zeige NOTCH1 Proteine) activation in osteocytes was prevented in matrix protein 1 (Dmp1 (zeige DMP1 Proteine))-Cre;Rosa(Notch (zeige NOTCH1 Proteine)) mice hemizygous for the Dmp1 (zeige DMP1 Proteine)-sclerostin (SOST) transgene.

  8. Results found that sclerostin enhances adipocyte differentiation in 3T3-L1 cells and reduced TAZ (zeige TAZ Proteine)-responsive transcriptional activity and TAZ (zeige TAZ Proteine)-responsive gene expression, indicating a role for TAZ (zeige TAZ Proteine) as a regulator of adipogenesis by sclerostin.

  9. Our results suggested that sclerostin could be expressed in the liver and sustained successfully at high levels in the blood by using the PhiC31 integrase system, leading to trabecular bone loss.

  10. Sclerostin depletion enhances tibial fracture healing.

Sclerostin (SOST) Protein Überblick

Protein Überblick

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Genbezeichner und Symbole assoziert mit Sclerostin Proteine (SOST)

  • sclerostin (LOC100313724)
  • sclerostin (SOST)
  • sclerostin (Sost)
  • sclerostin-like (LOC100513306)
  • 5430411E23Rik Protein
  • CDD Protein
  • LOC100313724 Protein
  • VBCH Protein

Bezeichner auf Proteinebene für Sclerostin Proteine (SOST)

sclerostin , sclerosteosis

GENE ID SPEZIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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