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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Zusätzlich bieten wir Ihnen Sclerostin Antikörper (128) und Sclerostin Proteine (18) und viele weitere Produktgruppen zu diesem Protein an.
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Human Sclerostin ELISA Kit für Sandwich ELISA - ABIN457071
Cidem, Usta, Karacan, Kucuk, Uludag, Gun: Effects of sex steroids on serum sclerostin levels during the menstrual cycle. in Gynecologic and obstetric investigation 2013
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Human Sclerostin ELISA Kit für Sandwich ELISA - ABIN415155
Brabnikova Maresova, Pavelka, Stepan: Acute effects of glucocorticoids on serum markers of osteoclasts, osteoblasts, and osteocytes. in Calcified tissue international 2013
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Rat (Rattus) Sclerostin ELISA Kit für Sandwich ELISA - ABIN416496
Kim, Lee, Jo, Song, Lim, Park, Bonewald, Kim: Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes. in Life sciences 2013
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Mouse (Murine) Sclerostin ELISA Kit für Sandwich ELISA - ABIN426039
Yorgan, Peters, Jeschke, Benisch, Jakob, Amling, Schinke: The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015
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Rat (Rattus) Sclerostin ELISA Kit für Sandwich ELISA - ABIN585201
Ferreira, Ferrari, Neves, Cavallari, Dominguez, Dos Reis, Graciolli, Oliveira, Liu, Sabbagh, Jorgetti, Schiavi, Moysés: Effects of dietary phosphate on adynamic bone disease in rats with chronic kidney disease--role of sclerostin? in PLoS ONE 2013
Sclerostin But Not Dickkopf-1 (zeige DKK1 ELISA Kits) has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women
An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (zeige COL1A2 ELISA Kits).
High serum levels of sclerostin and Dkk-1 (zeige DKK1 ELISA Kits) are associated with acute ischaemic stroke
The increased expression of sclerostin in the liver and the association with histologic cholangitis may explain the high serum levels of this protein in patients with primary biliary cirrhosis.
SOST silencing promotes the proliferation, invasion and migration, and decreases the apoptosis of human retinoblastoma cells by activating the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway.
Sclerostin concentrations in serum significantly decreased and IGF-I (zeige IGF1 ELISA Kits) significantly increased after 12months of resistance training or JUMP.
observed an association between sclerostin levels with fasting insulin (zeige INS ELISA Kits) levels and homoeostatic model assessment-insulin (zeige INS ELISA Kits) resistance, but there was no clear association with type 2 diabetes risk.
Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR (zeige EGFR ELISA Kits). Its involvement with other hormones of mineral homeostasis (FGF23 (zeige FGF23 ELISA Kits)/Klotho (zeige KL ELISA Kits) and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney
In chronic kidney disease, serum levels of the Wnt (zeige WNT2 ELISA Kits) inhibitors DKK1 (zeige DKK1 ELISA Kits) and sclerostin are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin, as opposed to DKK1 (zeige DKK1 ELISA Kits), may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD (zeige DPEP1 ELISA Kits)), particularly in dialysis patients.
Vitamin D receptor (zeige VDR ELISA Kits) agonism by paricalcitol causes a moderate increase in serum sclerostin in CKD patients, and this effect is modified by circulating pentosidine levels.
These results show that osteocytes and/or osteoblasts secrete factors regulating beige (zeige LYST ELISA Kits) adipogenesis, at least in part, through the Wnt (zeige WNT2 ELISA Kits)-signaling inhibitor sclerostin.
In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (zeige GJA1 ELISA Kits)+/-or Sost+/-mice
loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (zeige TNFSF11 ELISA Kits) and SOST, leading to osteoclast inhibition and Wnt (zeige WNT2 ELISA Kits) activation together.
humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (zeige PFDN5 ELISA Kits).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.
Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.
complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.
In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.
These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.
Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (zeige WNT2 ELISA Kits) signaling pathway inhibition.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.