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The protein encoded by SMARCD2 is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Zusätzlich bieten wir Ihnen SMARCD2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Data show that both CEBPE (zeige CEBPE Antikörper) and SMARCD2 loss-of-function mutations identified in patients with neutrophil-specific granule deficiency (SGD (zeige SGCD Antikörper)) abolish the interaction with SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) and secondary granule gene expression, thus providing a molecular basis for this disease.
Defective expression of SMARCD2 (SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper)-related, matrix-associated (zeige SMARCA5 Antikörper), actin-dependent regulator of chromatin, subfamily D (zeige CYP Antikörper), member 2) leads to transcriptional and chromatin changes in acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)) promyelocytic cells, suggesting SMARCD2 is a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia.
the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated.
the Rac (zeige AKT1 Antikörper)- and Unkempt-dependent process leading to BAF60b ubiquitination takes place in the nuclear compartment
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2
, 60 kDa BRG-1/Brm-associated factor subunit B
, BRG1-associated factor 60B
, SWI/SNF complex 60 kDa subunit B
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
, Swp73-like protein
, chromatin remodeling complex BAF60B subunit
, mammalian chromatin remodeling complex BRG1-associated factor 60B