SUMO1/sentrin Specific Protease 6 Proteine (SENP6)

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1\; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. Zusätzlich bieten wir Ihnen SENP6 Antikörper (121) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SENP6 215351 Q6P7W0
SENP6 26054 Q9GZR1
Ratte SENP6 SENP6 300860  
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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SENP6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu SUMO1/sentrin Specific Protease 6 (SENP6) Interaktionspartnern

Mouse (Murine) SUMO1/sentrin Specific Protease 6 (SENP6) Interaktionspartner

  1. Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6.

Human SUMO1/sentrin Specific Protease 6 (SENP6) Interaktionspartner

  1. LANA could bind to the promoter region of the SENP6 gene and inhibit SENP6 expression while the regulated SENP6 could in turn modulate the abundance of LANA through desumoylation.

  2. the structure of SENP2 (zeige SUMO1 Proteine)-Loop1 in complex with SUMO2 (zeige SUMO2 Proteine) was solved at 2.15 A resolution, and reveals the details of an interface exclusive to SENP6/7 and the formation of unique contacts between both proteins

  3. Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family.

  4. study of substrate specificity of SENP6; it is also capable of cleaving mixed chains of SUMO-1 (zeige SUMO1 Proteine) and SUMO-2 (zeige SUMO2 Proteine)/3; mutation of catalytic cysteine of results in its accumulation in PML (zeige PML Proteine) NBs (zeige NBN Proteine); findings indicate SUMO-modified PML (zeige PML Proteine) is a substrate of SENP6

  5. Results reveal a novel mechanism whereby the finely balanced activities of SENP6 and RNF4 control vertebrate kinetochore assembly through SUMO-targeted destabilization of inner plate components.

  6. SENP1 (zeige SENP1 Proteine) localization is influenced by expression and localization of SUMO-1 (zeige SUMO1 Proteine)-conjugated target proteins within the cell.

  7. SUSP1 plays an important role in the control of the transcriptional activity of RXRalpha (zeige RXRA Proteine) and thus in the RXRalpha (zeige RXRA Proteine)-mediated cellular processes

  8. We have investigated the specificity of SUSP1 using vinyl sulfone inhibitors and model substrates. SUSP1 has a strong paralogue bias toward SUMO2 (zeige SUMO2 Proteine)/3 and acts preferentially on substrates containing three or more SUMO2 (zeige SUMO2 Proteine)/3 moieties

  9. SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2

SENP6 Protein Überblick

Protein Überblick

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1\; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA\; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000

Genbezeichner und Symbole assoziert mit SENP6

  • SUMO1/sentrin specific peptidase 6 (SENP6)
  • SUMO/sentrin specific peptidase 6 (Senp6)
  • SUMO1/sentrin specific peptidase 6 (Senp6)
  • 2810017C20Rik Protein
  • E130319N12Rik Protein
  • mKIAA0797 Protein
  • SSP1 Protein
  • SUSP1 Protein

Bezeichner auf Proteinebene für SENP6

SUMO1/sentrin specific peptidase 6 , SUMO1/sentrin specific protease 6 , SUMO-1-specific protease 1 , SUMO/sentrin specific protease 6 , sentrin-specific protease 6 , sentrin/SUMO-specific protease SENP6 , 2810017C20Rik , SUMO/sentrin specific peptidase 6 , Sumo1/sentrin/SMT3 specific peptidase 6

GENE ID SPEZIES
462829 Pan troglodytes
215351 Mus musculus
481883 Canis lupus familiaris
26054 Homo sapiens
300860 Rattus norvegicus
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