SUMO1 Activating Enzyme Subunit 2 Proteine (UBA2)

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. Zusätzlich bieten wir Ihnen SUMO1 Activating Enzyme Subunit 2 Antikörper (75) und SUMO1 Activating Enzyme Subunit 2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
UBA2 10054 Q9UBT2
UBA2 50995 Q9Z1F9
Ratte UBA2 UBA2 308508  
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
543,09 €
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UBA2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu SUMO1 Activating Enzyme Subunit 2 (UBA2) Interaktionspartnern

Human SUMO1 Activating Enzyme Subunit 2 (UBA2) Interaktionspartner

  1. We propose that disturbance of the SUMOylation pathway, mediated by pathogenic variants in UBA2, is a novel mechanism for aplasia cutis congenita and other phenotypic abnormalities.

  2. Here, we show that hHR23A utilizes both the UBA2 and XPCB domains to form a stable complex with Vpr, linking Vpr directly to cellular DNA repair pathways and their probable exploitation by the virus.

  3. Data indicate the role of anti-SUMO activating enzyme SAE1 (zeige SAE1 Proteine) and SAE2 (zeige RBBP8 Proteine) antibody as marker of dermatomyositis.

  4. Data show that the SAE2 (zeige RBBP8 Proteine) subunit of the small ubiquitin-like modifier (SUMO (zeige SUMO1 Proteine)) E1 is autoSUMOylated at residue Lys (zeige LYZ Proteine)-236, and SUMOylation was catalyzed by Ubc9 (zeige UBE2I Proteine) at several additional Lys (zeige LYZ Proteine) residues surrounding the catalytic Cys (zeige DNAJC5 Proteine)-173 of SAE2 (zeige RBBP8 Proteine).

  5. loss of SAE1 (zeige SAE1 Proteine)/2 activity drives synthetic lethality with Myc (zeige MYC Proteine); inactivation of SAE2 (zeige RBBP8 Proteine) leads to mitotic catastrophe and cell death upon Myc (zeige MYC Proteine) hyperactivation; findings in Myc (zeige MYC Proteine)-high breast cancers suggest low tumor SAE1 (zeige SAE1 Proteine) and SAE2 (zeige RBBP8 Proteine) correlates metastasis-free survival

  6. The mammalian E1 subunits can be imported separately, identify nuclear localization signals (NLSs) in Aos1 and in Uba2, and demonstrate that their import is mediated by importin alpha/beta in vitro and in intact cells.

  7. structures of heterodimeric Sae1 (zeige SAE1 Proteine)/Sae2 (zeige RBBP8 Proteine)-Mg.ATP and Sae1 (zeige SAE1 Proteine)/Sae2 (zeige RBBP8 Proteine)-SUMO-1 (zeige SUMO1 Proteine)-Mg.ATP complexes

  8. UBA2 stabilizes APOBEC3G by preventing ubiquitin chain elongation and proteasome-mediated proteolysis.

SUMO1 Activating Enzyme Subunit 2 (UBA2) Protein Überblick

Protein Überblick

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1\; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999

Genbezeichner und Symbole assoziert mit UBA2

  • SUMO1 activating enzyme subunit 2 (MICPUN_63834)
  • SUMO1 activating enzyme subunit 2 (MICPUCDRAFT_36729)
  • SUMO-activating enzyme subunit 2 (SAE2)
  • ubiquitin-like modifier activating enzyme 2 (UBA2)
  • ubiquitin-like modifier activating enzyme 2 (Uba2)
  • ubiquitin-like modifier activating enzyme 2 (uba2)
  • AA986091 Protein
  • Arx Protein
  • ATSAE2 Protein
  • EMB2764 Protein
  • EMBRYO DEFECTIVE 2764 Protein
  • F3K23.23 Protein
  • F3K23_23 Protein
  • sae2 Protein
  • sae2-B Protein
  • sae2b Protein
  • SUMO-activating enzyme 2 Protein
  • UBA1 Protein
  • uba2-a Protein
  • uba2-b Protein
  • Ubl1a2 Protein
  • uble1b Protein
  • uble1b-B Protein
  • wu:fi17g06 Protein
  • zgc:66354 Protein

Bezeichner auf Proteinebene für UBA2

SUMO1 activating enzyme subunit 2 , SUMO-1 activating enzyme subunit 2 , SUMO-activating enzyme subunit 2 , UBA2, ubiquitin-activating enzyme E1 homolog , anthracycline-associated resistance ARX , ubiquitin-like 1-activating enzyme E1B , Sumo-1 activating enzyme subunit 2 , ubiquitin-like 1 (sentrin) activating enzyme E1B , ubiquitin-like 1 (sentrin) activating enzyme subunit 2 , SUMO-activating enzyme subunit 2-A , SUMO-activating enzyme subunit 2-B , ubiquitin-like 1-activating enzyme E1B-A , ubiquitin-like 1-activating enzyme E1B-B , SUMO1 activating enzyme subunit 2b

GENE ID SPEZIES
8248549 Micromonas sp. RCC299
9689179 Micromonas pusilla CCMP1545
816686 Arabidopsis thaliana
10054 Homo sapiens
50995 Mus musculus
308508 Rattus norvegicus
476490 Canis lupus familiaris
399235 Xenopus laevis
406672 Danio rerio
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