ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Proteine (ST8SIA4)

The protein encoded by ST8SIA4 catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). Zusätzlich bieten wir Ihnen ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Antikörper (37) und ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Kits (15) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ST8SIA4 7903 Q92187
ST8SIA4 20452 Q64692
Ratte ST8SIA4 ST8SIA4 116696  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen 10 bis 15 Tage
246,67 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.837,30 €
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Hefe Pan troglodytes His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.837,30 €
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ST8SIA4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)
,

Weitere Proteine zu ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) Interaktionspartnern

Human ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) Interaktionspartner

  1. The polybasic region of the polysialyltransferase ST8Sia-IV binds directly to NCAM (zeige NCAM1 Proteine).

  2. Sequence Requirements for Neuropilin-2 (zeige NRP2 Proteine) Recognition by ST8SiaIV and Polysialylation of Its O-Glycans.

  3. ST8SIA4 gene is involved in the development of multidrug resistance via PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathway in chronic myeloid leukemia (zeige BCL11A Proteine).

  4. this study indicated that sialylation involved in the development of MDR of AML (zeige RUNX1 Proteine) cells probably through ST3GAL5 (zeige ST3GAL5 Proteine) or ST8SIA4 regulating the activity of PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling and the expression of P-gp (zeige ABCB4 Proteine) and MRP1 (zeige MDM4 Proteine).

  5. ST8SiaIV synthesized polySia selectively on a NRP2 (zeige NELL2 Proteine) glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans.

  6. The ST8SiaIV/PST polybasic region plays a critical role in substrate recognition.

  7. polysialylated NCAM (zeige NCAM1 Proteine) persistence, up-regulated polysialyltransferase-1 mRNA and previously uncovered defective myelin-associated glycoprotein (zeige MAG Proteine) may be early pathogenetic events in adult-onset autosomal-dominant leukodystrophy

  8. SIAT8D has a role in neural development and sialic acid synthesis on NCAM (zeige NCAM1 Proteine)

  9. Pancreatitis risk was highest in individuals with abnormalities in pancreatic duct(CFTR (zeige CFTR Proteine)) and acini (PST1) indicating that PST1 is a modifier gene for CFTR (zeige CFTR Proteine)-related idiopathic chronic pancreatitis.

  10. The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 (zeige ST8SIA2 Proteine) by valproic acid in HUVEC and tumor cell lines are reported.

Pig (Porcine) ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) Interaktionspartner

  1. Pig cDNA provides a basis for uncovering the roles of ST8Sia IV during piglet development and maturation.

Mouse (Murine) ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) Interaktionspartner

  1. Mice deficient for ST8SiaIV have impaired long-term spatial memory in two tasks that critically rely on the hippocampus.

  2. Results demonstrate that the early development of calbindin (zeige CALB1 Proteine)-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM (zeige NCAM1 Proteine) and requires the activity of both St8sia2 (zeige ST8SIA2 Proteine) and St8sia4

  3. SULT1A1 (zeige SULT1A1 Proteine) is responsible for bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol.

  4. NCAM (zeige NCAM1 Proteine)-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM (zeige NCAM1 Proteine)-140 catalyzed by STX (zeige ST8SIA2 Proteine), but not by PST, enhanced NCAM (zeige NCAM1 Proteine)-mediated cell migration, but not cell proliferation or motility.

  5. ST8SiaIV synthesized polySia selectively on a NRP2 (zeige NRP2 Proteine) glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans.

  6. Results indicate that the polySTs ST8SiaII (zeige ST8SIA2 Proteine) and ST8SiaIV not only recognize an acidic patch in the FN1 (zeige FN1 Proteine) domain of NCAM (zeige NCAM1 Proteine) but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.

  7. the negative and positive effects of ST8SiaIV overexpression observed during peripheral nerve regeneration suggest that an optimized time- and differentiation-dependent control of expression in Schwann cells may further improve nerve regeneration

  8. While both ST8SiaII (zeige ST8SIA2 Proteine) and ST8SiaIV mRNA levels decrease around the time of eye opening in mouse visual cortex, only ST8SiaII (zeige ST8SIA2 Proteine) mRNA level reduction is regulated by sensory experience

  9. ST8Sia4 knockout mice display a decreased motivation in social interaction. This deficit can be partly explained by olfactory deficits and was associated with a clear decrease in PSA (zeige NPEPPS Proteine)-NCAM (zeige NCAM1 Proteine) expression in all brain regions analyzed.

  10. This study demonistrated that mice lacking St8siaIV polysialyltransferase have an accelerated onset of remyelination after cuprizone-induced demyelination.

ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) Protein Überblick

Protein Überblick

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit ST8SIA4

  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (ST8SIA4)
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (St8sia4)
  • sulfotransferase family 1A, phenol-preferring, member 1 (Sult1a1)
  • AI266890 Protein
  • PST Protein
  • PST-1 Protein
  • PST1 Protein
  • SIAT8-D Protein
  • Siat8d Protein
  • ST1A1 Protein
  • ST8Sia-IV Protein
  • ST8SiaIV Protein
  • Stp Protein
  • Stp1 Protein

Bezeichner auf Proteinebene für ST8SIA4

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase , sialyltransferase 8D (alpha-2, 8-polysialyltransferase) , CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase , SIAT8-D , ST8SiaIV , alpha-2,8-sialyltransferase 8D , polysialyltransferase-1 , sialyltransferase 8 (alpha-2, 8-polysialytransferase) D , sialyltransferase 8D , sialyltransferase St8Sia IV , sialytransferase St8Sia IV , alpha-2,8-polysialyltransferase IV , ST8Sia IV , sialyltransferase 8 (alpha-2, 8-sialyltransferase) D , polysialyltransferase , sialyltransferase 8 (alpha-2 8-polysialyltransferase) D , sialyltransferase 8 (alpha-2 8-polysialytransferase) D , sialyltransferase 8 (alpha-2, 8-polysialyltransferase) D , sialyltransferase 8 (alpha-2, 8-sialytransferase) D , polysialyltransferase 1 , ST1A4 , aryl sulfotransferase , arylsulfotransferase ST1A4 , mSTp1 , phenol sulfotransferase , phenol/aryl sulfotransferase , sulfokinase , sulfotransferase 1A1 , sulfotransferase, phenol preferring 1

GENE ID SPEZIES
374155 Gallus gallus
7903 Homo sapiens
488886 Canis lupus familiaris
641356 Sus scrofa
407768 Bos taurus
20452 Mus musculus
116696 Rattus norvegicus
461971 Pan troglodytes
101112314 Ovis aries
20887 Mus musculus
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