SMAD Specific E3 Ubiquitin Protein Ligase 2 Proteine (SMURF2)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Zusätzlich bieten wir Ihnen SMURF2 Antikörper (72) und SMURF2 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SMURF2 64750 Q9HAU4
SMURF2 66313 A2A5Z6
Ratte SMURF2 SMURF2 303614  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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SMURF2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Interaktionspartnern

Rhesus Monkey SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Interaktionspartner

  1. results provide the evidence that Smurf2 may play specific roles in glandular secretion, trophoblastic cell invasion, and placentation through mediating the expression of the related proteins of TGF-beta (zeige TGFB1 Proteine) signaling pathway during early pregnancy

Human SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Interaktionspartner

  1. Low SMURF2 expression is associated with breast cancer organoid invasiveness.

  2. Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.

  3. found that phospho-AIMP2 (zeige AIMP2 Proteine) dissociated from the multi-tRNA synthetase complex and translocated to the nucleus, where it bound to Smurf2

  4. Ectopic expression of human Smurf2 driven by the Col2a1 (zeige COL2A1 Proteine) promoter accelerated disc degeneration in Col2a1 (zeige COL2A1 Proteine)-Smurf2 transgenic mice, and that higher levels of connective tissue growth factor (zeige CTGF Proteine) protein and mRNA were present in Col2a1 (zeige COL2A1 Proteine)-Smurf2 transgenic discs, indicate that Smurf2 accelerates disc degeneration via upregulation of connective tissue growth factor (zeige CTGF Proteine).

  5. data suggest for the first time that the choice of binding partners for SMURF2 can sustain or repress TGFbeta (zeige TGFB1 Proteine) signaling, and RNF11 (zeige RNF11 Proteine) may promote TGFbeta (zeige TGFB1 Proteine)-induced cell migration.

  6. Neddylation of Smurf1 (zeige SMURF1 Proteine) activates its ubiquitin ligase activity and Smurf2 exerts Nedd8 (zeige NEDD8 Proteine) ligase activity. This study provided new clues of Smurf2 activation regulation.

  7. The Smurf2 acts in a sumoylation-regulated manner to suppress TGFbeta (zeige TGFB1 Proteine)-induced Epithelial-mesenchymal transition.

  8. the findings of this study demonstrate that the downregulation of SnoN (zeige SKIL Proteine) expression in hRPTECs under high-glucose conditions is mediated by the increased expression of Smurf2 through the TGF-b1/Smad (zeige SMAD1 Proteine) signaling pathway.

  9. SMURF2 is a critical target of USP15 (zeige USP15 Proteine) in the TGF-beta (zeige TGFB1 Proteine) signaling pathway.

  10. Data show that miR15b mediates SMURF2 expression in pancreatic cancer and suggest miR15b as an oncogene (zeige RAB1A Proteine) by promoting epithelial-mesenchymal transition and SMURF2 as a tumor suppressor gene which expression is inhibited by miR15b in pancreatic cancer.

Mouse (Murine) SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Interaktionspartner

  1. Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.

  2. Young Smurf2-deficient mice develop milder osteoarthritis in knee articular cartilage compared to WT mice after surgical destabilization of the medial meniscus.

  3. TAT (zeige TAT Proteine) fused to WW2/WW3 of Smurf2 could interfere with TGF-beta (zeige TGFB1 Proteine) signaling and reduce ArgI gene expression.

  4. Smurf-mediated endocytosis of Patched1 (zeige PTCH1 Proteine) is required in sonic hedgehog (zeige SHH Proteine) signal reception

  5. Data indicate that TNF receptor associated factor 4 (TRAF4 (zeige TRAF4 Proteine)) recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2 (zeige DAZAP2 Proteine)).

  6. Expression of Smurf2 was increased with age and in response to regenerative stress during serial transplantation, our findings suggest that Smurf2 plays an important role in regulating HSC (zeige FUT1 Proteine) self-renewal and aging.

  7. Akt (zeige AKT1 Proteine) regulates osteoblast differentiation by enhancing the protein stability and transcriptional activity of Runx2 (zeige RUNX2 Proteine) through regulation of degradation of Smurf2.

  8. that Smurf2 is an important nonredundant negative regulator of virus-triggered type I IFN signaling by targeting VISA (zeige MAVS Proteine) for K48-linked ubiquitination and degradation.

  9. Smurf2 mediates ubiquitination and degradation of YY1 (zeige YY1 Proteine), a key germinal centre transcription factor.

  10. Smurf2 deficiency increased the susceptibility of mice to spontaneous tumorigenesis, most notably B-cell lymphoma

Xenopus laevis SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Interaktionspartner

  1. Data demonstrate that Smurf1 (zeige SMURF1 Proteine) and Smurf2 have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.

SMURF2 Protein Überblick

Protein Überblick

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).

Genbezeichner und Symbole assoziert mit SMURF2

  • SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)
  • SMAD specific E3 ubiquitin protein ligase 2 (smurf2)
  • SMAD specific E3 ubiquitin protein ligase 2 (Smurf2)
  • SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S)
  • 2810411E22Rik Protein
  • AI558114 Protein
  • AI649275 Protein
  • RGD1310067 Protein
  • SMURF2 Protein
  • wu:fb82a11 Protein
  • wu:fc41c02 Protein

Bezeichner auf Proteinebene für SMURF2

SMAD specific E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase SMURF2-like , e3 ubiquitin-protein ligase SMURF2-like , E3 ubiquitin ligase SMURF2 , E3 ubiquitin-protein ligase SMURF2 , SMAD ubiquitination regulatory factor 2 , SMAD-specific E3 ubiquitin-protein ligase 2 , hSMURF2 , E3 ubiquitin ligase Smurf2

GENE ID SPEZIES
100064082 Equus caballus
100230714 Taeniopygia guttata
454761 Pan troglodytes
480470 Canis lupus familiaris
717902 Macaca mulatta
100038194 Xenopus (Silurana) tropicalis
100358121 Oryctolagus cuniculus
100374187 Saccoglossus kowalevskii
100386392 Callithrix jacchus
100459970 Pongo abelii
100473715 Ailuropoda melanoleuca
100603634 Nomascus leucogenys
64750 Homo sapiens
66313 Mus musculus
303614 Rattus norvegicus
427809 Gallus gallus
540826 Bos taurus
398372 Xenopus laevis
563633 Danio rerio
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