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E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Zusätzlich bieten wir Ihnen SMURF2 Antikörper (72) und SMURF2 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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results provide the evidence that Smurf2 may play specific roles in glandular secretion, trophoblastic cell invasion, and placentation through mediating the expression of the related proteins of TGF-beta (zeige TGFB1 ELISA Kits) signaling pathway during early pregnancy
Low SMURF2 expression is associated with breast cancer organoid invasiveness.
Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.
found that phospho-AIMP2 (zeige AIMP2 ELISA Kits) dissociated from the multi-tRNA synthetase complex and translocated to the nucleus, where it bound to Smurf2
Ectopic expression of human Smurf2 driven by the Col2a1 (zeige COL2A1 ELISA Kits) promoter accelerated disc degeneration in Col2a1 (zeige COL2A1 ELISA Kits)-Smurf2 transgenic mice, and that higher levels of connective tissue growth factor (zeige CTGF ELISA Kits) protein and mRNA were present in Col2a1 (zeige COL2A1 ELISA Kits)-Smurf2 transgenic discs, indicate that Smurf2 accelerates disc degeneration via upregulation of connective tissue growth factor (zeige CTGF ELISA Kits).
data suggest for the first time that the choice of binding partners for SMURF2 can sustain or repress TGFbeta (zeige TGFB1 ELISA Kits) signaling, and RNF11 (zeige RNF11 ELISA Kits) may promote TGFbeta (zeige TGFB1 ELISA Kits)-induced cell migration.
Neddylation of Smurf1 (zeige SMURF1 ELISA Kits) activates its ubiquitin ligase activity and Smurf2 exerts Nedd8 (zeige NEDD8 ELISA Kits) ligase activity. This study provided new clues of Smurf2 activation regulation.
The Smurf2 acts in a sumoylation-regulated manner to suppress TGFbeta (zeige TGFB1 ELISA Kits)-induced Epithelial-mesenchymal transition.
the findings of this study demonstrate that the downregulation of SnoN (zeige SKIL ELISA Kits) expression in hRPTECs under high-glucose conditions is mediated by the increased expression of Smurf2 through the TGF-b1/Smad (zeige SMAD1 ELISA Kits) signaling pathway.
SMURF2 is a critical target of USP15 (zeige USP15 ELISA Kits) in the TGF-beta (zeige TGFB1 ELISA Kits) signaling pathway.
Data show that miR15b mediates SMURF2 expression in pancreatic cancer and suggest miR15b as an oncogene (zeige RAB1A ELISA Kits) by promoting epithelial-mesenchymal transition and SMURF2 as a tumor suppressor gene which expression is inhibited by miR15b in pancreatic cancer.
Young Smurf2-deficient mice develop milder osteoarthritis in knee articular cartilage compared to WT mice after surgical destabilization of the medial meniscus.
TAT (zeige TAT ELISA Kits) fused to WW2/WW3 of Smurf2 could interfere with TGF-beta (zeige TGFB1 ELISA Kits) signaling and reduce ArgI gene expression.
Smurf-mediated endocytosis of Patched1 (zeige PTCH1 ELISA Kits) is required in sonic hedgehog (zeige SHH ELISA Kits) signal reception
Data indicate that TNF receptor associated factor 4 (TRAF4 (zeige TRAF4 ELISA Kits)) recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2 (zeige DAZAP2 ELISA Kits)).
Expression of Smurf2 was increased with age and in response to regenerative stress during serial transplantation, our findings suggest that Smurf2 plays an important role in regulating HSC (zeige FUT1 ELISA Kits) self-renewal and aging.
Akt (zeige AKT1 ELISA Kits) regulates osteoblast differentiation by enhancing the protein stability and transcriptional activity of Runx2 (zeige RUNX2 ELISA Kits) through regulation of degradation of Smurf2.
that Smurf2 is an important nonredundant negative regulator of virus-triggered type I IFN signaling by targeting VISA (zeige MAVS ELISA Kits) for K48-linked ubiquitination and degradation.
Smurf2 mediates ubiquitination and degradation of YY1 (zeige YY1 ELISA Kits), a key germinal centre transcription factor.
Smurf2 deficiency increased the susceptibility of mice to spontaneous tumorigenesis, most notably B-cell lymphoma
Data demonstrate that Smurf1 (zeige SMURF1 ELISA Kits) and Smurf2 have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
SMAD specific E3 ubiquitin protein ligase 2
, E3 ubiquitin-protein ligase SMURF2-like
, e3 ubiquitin-protein ligase SMURF2-like
, E3 ubiquitin ligase SMURF2
, E3 ubiquitin-protein ligase SMURF2
, SMAD ubiquitination regulatory factor 2
, SMAD-specific E3 ubiquitin-protein ligase 2
, E3 ubiquitin ligase Smurf2