anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Antikörper

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Zusätzlich bieten wir Ihnen SMURF2 Kits (4) und SMURF2 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SMURF2 64750 Q9HAU4
SMURF2 66313 A2A5Z6
SMURF2 303614  
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Top anti-SMURF2 Antikörper auf antikoerper-online.de

Showing 10 out of 72 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB The anti-SMURF2 Pab (ABIN388830) is used in Western blot to detect SMURF2 in mouse brain tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB Western blot analysis of anti-SMURF2 Pab (ABIN388831) in 293 cell line lysate (35 µg/lane). SMURF2(arrow) was detected using the purified polyclonal antibody (1:30 dilution) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of SMURF2 expression in SMMC whole cell lysates (lane 1). SMURF2 at 86KD was detected using rabbit anti- SMURF2 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$200.00
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat myocardium tissue labeled with Anti-SMURF2 Polyclonal Antibody, Unconjugated (ABIN753178) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-SMURF2 Polyclonal Antibody, Unconjugated (ABIN753178) at 1:200 followed by conjugation to the secondary antibody, (SP-0023), and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$295.90
Details
Human Maus Unkonjugiert IHC, WB Western Blot: SMURF2 Antibody (3E4) [NBP2-45890] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SMURF2. Immunohistochemistry: SMURF2 Antibody (3E4) [NBP2-45890] - Analysis of Human liver tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120 degrees C for 3min) 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Fledermaus Kaninchen Unkonjugiert WB   200 μL Anmelden zum Anzeigen 7 bis 9 Tage
$742.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: SMURF 2 Antibody [NBP2-20427] - Immunohistochemical analysis of paraffin-embedded Gastric ca, using antibody at 1:500 dilution. Western Blot: SMURF 2 Antibody [NBP2-20427] - Sample (30 ug of whole cell lysate) A: MCF-7 7. 5% SDS PAGE gel, diluted at 1:500. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Kaninchen Cy3 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details

SMURF2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-SMURF2 Antikörper

  1. Human Polyclonal SMURF2 Primary Antibody für IHC (p), WB - ABIN388830 : Zhang, Chang, Gehling, Hemmati-Brivanlou, Derynck: Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal SMURF2 Primary Antibody für IF, IHC (p) - ABIN388831 : Tajima, Goto, Yoshida, Shinomiya, Sekimoto, Yoneda, Miyazono, Imamura: Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 Pubmed References

Weitere Antikörper gegen SMURF2 Interaktionspartner

Rhesus Monkey SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Interaktionspartner

  1. results provide the evidence that Smurf2 may play specific roles in glandular secretion, trophoblastic cell invasion, and placentation through mediating the expression of the related proteins of TGF-beta (zeige TGFB1 Antikörper) signaling pathway during early pregnancy

Human SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Interaktionspartner

  1. Low SMURF2 expression is associated with breast cancer organoid invasiveness.

  2. Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.

  3. found that phospho-AIMP2 (zeige AIMP2 Antikörper) dissociated from the multi-tRNA synthetase complex and translocated to the nucleus, where it bound to Smurf2

  4. Ectopic expression of human Smurf2 driven by the Col2a1 (zeige COL2A1 Antikörper) promoter accelerated disc degeneration in Col2a1 (zeige COL2A1 Antikörper)-Smurf2 transgenic mice, and that higher levels of connective tissue growth factor (zeige CTGF Antikörper) protein and mRNA were present in Col2a1 (zeige COL2A1 Antikörper)-Smurf2 transgenic discs, indicate that Smurf2 accelerates disc degeneration via upregulation of connective tissue growth factor (zeige CTGF Antikörper).

  5. data suggest for the first time that the choice of binding partners for SMURF2 can sustain or repress TGFbeta (zeige TGFB1 Antikörper) signaling, and RNF11 (zeige RNF11 Antikörper) may promote TGFbeta (zeige TGFB1 Antikörper)-induced cell migration.

  6. Neddylation of Smurf1 (zeige SMURF1 Antikörper) activates its ubiquitin ligase activity and Smurf2 exerts Nedd8 (zeige NEDD8 Antikörper) ligase activity. This study provided new clues of Smurf2 activation regulation.

  7. The Smurf2 acts in a sumoylation-regulated manner to suppress TGFbeta (zeige TGFB1 Antikörper)-induced Epithelial-mesenchymal transition.

  8. the findings of this study demonstrate that the downregulation of SnoN (zeige SKIL Antikörper) expression in hRPTECs under high-glucose conditions is mediated by the increased expression of Smurf2 through the TGF-b1/Smad (zeige SMAD1 Antikörper) signaling pathway.

  9. SMURF2 is a critical target of USP15 (zeige USP15 Antikörper) in the TGF-beta (zeige TGFB1 Antikörper) signaling pathway.

  10. Data show that miR15b mediates SMURF2 expression in pancreatic cancer and suggest miR15b as an oncogene (zeige RAB1A Antikörper) by promoting epithelial-mesenchymal transition and SMURF2 as a tumor suppressor gene which expression is inhibited by miR15b in pancreatic cancer.

Mouse (Murine) SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Interaktionspartner

  1. Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.

  2. Young Smurf2-deficient mice develop milder osteoarthritis in knee articular cartilage compared to WT mice after surgical destabilization of the medial meniscus.

  3. TAT (zeige TAT Antikörper) fused to WW2/WW3 of Smurf2 could interfere with TGF-beta (zeige TGFB1 Antikörper) signaling and reduce ArgI gene expression.

  4. Smurf-mediated endocytosis of Patched1 (zeige PTCH1 Antikörper) is required in sonic hedgehog (zeige SHH Antikörper) signal reception

  5. Data indicate that TNF receptor associated factor 4 (TRAF4 (zeige TRAF4 Antikörper)) recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2 (zeige DAZAP2 Antikörper)).

  6. Expression of Smurf2 was increased with age and in response to regenerative stress during serial transplantation, our findings suggest that Smurf2 plays an important role in regulating HSC (zeige FUT1 Antikörper) self-renewal and aging.

  7. Akt (zeige AKT1 Antikörper) regulates osteoblast differentiation by enhancing the protein stability and transcriptional activity of Runx2 (zeige RUNX2 Antikörper) through regulation of degradation of Smurf2.

  8. that Smurf2 is an important nonredundant negative regulator of virus-triggered type I IFN signaling by targeting VISA (zeige MAVS Antikörper) for K48-linked ubiquitination and degradation.

  9. Smurf2 mediates ubiquitination and degradation of YY1 (zeige YY1 Antikörper), a key germinal centre transcription factor.

  10. Smurf2 deficiency increased the susceptibility of mice to spontaneous tumorigenesis, most notably B-cell lymphoma

Xenopus laevis SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Interaktionspartner

  1. Data demonstrate that Smurf1 (zeige SMURF1 Antikörper) and Smurf2 have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.

SMURF2 Antigen-Profil

Protein Überblick

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).

Genbezeichner und Symbole assoziert mit SMURF2

  • SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) Antikörper
  • SMAD specific E3 ubiquitin protein ligase 2 (smurf2) Antikörper
  • SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) Antikörper
  • SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S) Antikörper
  • 2810411E22Rik Antikörper
  • AI558114 Antikörper
  • AI649275 Antikörper
  • RGD1310067 Antikörper
  • SMURF2 Antikörper
  • wu:fb82a11 Antikörper
  • wu:fc41c02 Antikörper

Bezeichner auf Proteinebene für SMURF2

SMAD specific E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase SMURF2-like , e3 ubiquitin-protein ligase SMURF2-like , E3 ubiquitin ligase SMURF2 , E3 ubiquitin-protein ligase SMURF2 , SMAD ubiquitination regulatory factor 2 , SMAD-specific E3 ubiquitin-protein ligase 2 , hSMURF2 , E3 ubiquitin ligase Smurf2

GENE ID SPEZIES
100064082 Equus caballus
100230714 Taeniopygia guttata
454761 Pan troglodytes
480470 Canis lupus familiaris
717902 Macaca mulatta
100038194 Xenopus (Silurana) tropicalis
100358121 Oryctolagus cuniculus
100374187 Saccoglossus kowalevskii
100386392 Callithrix jacchus
100459970 Pongo abelii
100473715 Ailuropoda melanoleuca
100603634 Nomascus leucogenys
64750 Homo sapiens
66313 Mus musculus
303614 Rattus norvegicus
427809 Gallus gallus
540826 Bos taurus
398372 Xenopus laevis
563633 Danio rerio
Ausgewählte Anbieter für anti-SMURF2 (SMURF2) Antikörper
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