anti-SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) Antikörper

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. Zusätzlich bieten wir Ihnen SRGAP3 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SRGAP3 14270 Q91Z67
SRGAP3 9901 O43295
SRGAP3 500287  
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Top anti-SRGAP3 Antikörper auf antikoerper-online.de

Showing 10 out of 17 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC, WB   100 μL Anmelden zum Anzeigen 16 Days
$460.63
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: SRGAP3 Antibody [NBP1-88831] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli & vesicles. Western Blot: SRGAP3 Antibody [NBP1-88831] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10.Lane 2: Cerebral Cortex 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
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Human Kaninchen Unkonjugiert IF (p), IHC (p), WB   100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$295.90
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Fledermaus Kaninchen Unkonjugiert WB   50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
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Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: SRGAP3 Antibody [NBP2-38521] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells. Immunocytochemistry/Immunofluorescence: SRGAP3 Antibody  - Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB   50 μL Anmelden zum Anzeigen 13 bis 16 Tage
$313.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA Immunohistochemistry of Human esophagus cancer using SRGAP3 Polyclonal Antibody at dilution of 1:30 200 μL Anmelden zum Anzeigen 12 bis 14 Tage
$493.90
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Human Kaninchen Unkonjugiert IHC (p)   100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$420.00
Details

SRGAP3 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Mouse (Murine) ,


Human , ,


Rat (Rattus) ,


Weitere Antikörper gegen SRGAP3 Interaktionspartner

Mouse (Murine) SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) Interaktionspartner

  1. SrGAP3 plays a role in neurodevelopmental disorders.

  2. This study found a more than 15-fold enlargement of the lateral ventricles of homozygous SrGAP3-deficient mice.

  3. SrGAP3 dynamically regulates neuronal cytoskeletal reorganization through inhibition of the Rho GTPase Rac1 and interaction with actin remodeling proteins.

  4. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (zeige ARHGEF16 Antikörper) cells.

  5. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus

  6. These results show neurodevelopmental aberration in Srgap3(-/-) mice, with many of the observed phenotypes matching several schizophrenia-related intermediate phenotypes. Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders.

  7. Following sciatic nerve transection, srGAP3 in neurons is significantly increased in the ipsilateral relative to contralateral dorsal root ganglions, which peak at day 7 to day 14.

  8. srGAP3 is an inhibitor of actin dynamics and lamellipodia formation in primary fibroblasts. srGAP3 influences focal adhesion formation through the downregulation of Rac1.

  9. Data suggest a role for srGAP3 in the lateral positioning of post crossing axons within the ventrolateral funiculus.

  10. srGAP3 could regulate neuronal differentiation in a Rac1-dependent manner.

Human SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) Interaktionspartner

  1. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains.

  2. Nuclear-localized srGAP3 interacts with Brg1 (zeige SMARCA4 Antikörper). This interaction is mediated by the C-terminal of srGAP3 and the ATPase (zeige DNAH8 Antikörper) motif of Brg1 (zeige SMARCA4 Antikörper).

  3. deletion of SRGAP3 provides the most convincing explanation for our patient's phenotype, and our observations lend further weight to a causative role of SRGAP3 haploinsufficiency in mental retardation.

  4. conclude that srGAP3 has tumor suppressor-like activity in HMECs, likely through its activity as a negative regulator of Rac1

  5. Data suggest that MEGAP negatively regulates cell migration by perturbing the actin and microtubule cytoskeleton and by hindering the formation of focal complexes.

  6. We found no association between SRGAP3/MEGAP haploinsufficiency and mental retardation.

  7. Current evidence suggests that SRGAP3 is the major determinant of mental retardation in distal 3p deletions.

  8. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains.

SRGAP3 Antigen-Profil

Protein Überblick

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Genbezeichner und Symbole assoziert mit SRGAP3

  • SLIT-ROBO Rho GTPase activating protein 2 (Srgap2) Antikörper
  • SLIT-ROBO Rho GTPase activating protein 3 (SRGAP3) Antikörper
  • SLIT-ROBO Rho GTPase activating protein 3 (Srgap3) Antikörper
  • 9930124L22Rik Antikörper
  • AI448945 Antikörper
  • AI452337 Antikörper
  • Arhgap14 Antikörper
  • D130026O08Rik Antikörper
  • FBP2 Antikörper
  • Fnbp2 Antikörper
  • Gbi Antikörper
  • MEGAP Antikörper
  • mKIAA0411 Antikörper
  • RGD1563152 Antikörper
  • SRGAP2 Antikörper
  • srGAP3 Antikörper
  • WRP Antikörper

Bezeichner auf Proteinebene für SRGAP3

FBP-27 , SLIT-ROBO Rho GTPase-activating protein 2 , formin binding protein 2 , formin-binding protein 2 , formin-binding protein 27 , SLIT-ROBO Rho GTPase activating protein 2 , SLIT-ROBO Rho GTPase-activating protein 3 , WAVE-associated Rac GTPase activating protein , mental disorder-associated GAP , rho GTPase-activating protein 14 , WAVE-associated Rac GTPase-activating protein , brain stress early protein Gbi , rho GTPase activating protein 14 , srGAP2

GENE ID SPEZIES
14270 Mus musculus
9901 Homo sapiens
610229 Canis lupus familiaris
500287 Rattus norvegicus
259302 Mus musculus
Ausgewählte Anbieter für anti-SRGAP3 (SRGAP3) Antikörper
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