anti-SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) Antikörper

SHANK2 encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Zusätzlich bieten wir Ihnen SHANK2 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SHANK2 22941 Q9UPX8
SHANK2 171093 Q9QX74
SHANK2 210274 Q80Z38
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Top anti-SHANK2 Antikörper auf antikoerper-online.de

Showing 10 out of 144 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
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Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Maus Kaninchen Unkonjugiert WB SHANK2 Antibody (Center) (ABIN656710) western blot analysis in mouse bladder tissue lysates (35 µg/lane). This demonstrates the SHANK2 antibody detected the SHANK2 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of SHANK2 Antibody (Center) in Mouse bladder tissue lysates (35ug/lane).This demonstrates the SHANK2 antibody detected the SHANK2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from RAW264.7/Jurkat/HepG2/COLO cells, using SHANK2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
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Human Maus Unkonjugiert AA, ICC, IF, IHC, IP, WB Shank2 Rat Brain Membrane Western Blotting. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
411,87 €
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Human Kaninchen Unkonjugiert ELISA, WB 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
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Human Kaninchen Unkonjugiert IP, WB Western blot analysis of SHANK2 expression in Jurkat (A), IMR32 (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
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Ratte Maus Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Western Blot: SHANK2 Antibody (S23b-49) [NBP2-12913] - analysis of Rat brain membrane lysate showing detection of SHANK protein using Mouse Anti-SHANK Monoclonal Antibody, Clone S23b-49 . Load: 15 ug protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-SHANK Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 0.1 mg Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
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Human Kaninchen Unkonjugiert IHC (p), ELISA, WB Human Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
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SHANK2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-SHANK2 Antikörper

  1. Mammalian Monoclonal SHANK2 Primary Antibody für ISt, IHC - ABIN1304902 : Gill, Droubi, Giovedi, Fedder, Bury, Bosco, Sceniak, Benfenati, Sabo: Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo. in Journal of cell science 2015 (PubMed)
    Show all 26 Pubmed References

  2. Mammalian Monoclonal SHANK2 Primary Antibody für ISt, IHC - ABIN1304953 : Peykov, Berkel, Schoen, Weiss, Degenhardt, Strohmaier, Weiss, Proepper, Schratt, Nöthen, Boeckers, Rietschel, Rappold: Identification and functional characterization of rare SHANK2 variants in schizophrenia. in Molecular psychiatry 2015 (PubMed)
    Show all 12 Pubmed References

  3. Human Monoclonal SHANK2 Primary Antibody für AA, ICC - ABIN863120 : Nagura, Ishikawa, Kobayashi, Takao, Tanaka, Nishikawa, Tamura, Shiosaka, Suzuki, Miyakawa, Fujiyoshi, Doi et al.: Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 ... in Molecular brain 2013 (PubMed)

Weitere Antikörper gegen SHANK2 Interaktionspartner

Human SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) Interaktionspartner

  1. The present study demonstrated that depletion of SHANK2 inhibited the osteo/dentinogenic differentiation potentials in human stem cells from apical papilla

  2. variants in the SHANK2 gene in a schizophrenia patient cohort

  3. Knockdown of endogenous Shank2E or overexpression of a dominant-negative Shank2E mutant inhibited the glucocorticoid-mediated increase in CFTR (zeige CFTR Antikörper).

  4. syndapin I (zeige PACSIN1 Antikörper) functions reflected direct, SH3 domain (zeige ITSN1 Antikörper)-mediated associations and functional interactions with ProSAP1/Shank2.

  5. Lack of association between NLGN3 (zeige NLGN3 Antikörper), NLGN4 (zeige NLGN4X Antikörper), SHANK2 and SHANK3 (zeige SHANK3 Antikörper) gene variants and autism spectrum disorder in a Chinese population.

  6. deletion of ProSAP1/Shank2 results in an early, brain-region-specific upregulation of ionotropic glutamate (zeige GRIN1 Antikörper) receptors at the synapse and increased levels of ProSAP2/Shank3 (zeige SHANK3 Antikörper)

  7. we confirmed that de novo SHANK2 deletions are present in patients with ASD (zeige ARSD Antikörper) and showed that several SHANK2 variants reduce the number of synapses in vitro

  8. dominant negative effect translates into dose-dependent altered cognitive behavior of SHANK2-R462X-expressing mice, with an impact on the penetrance of ASD (zeige ARSD Antikörper)

  9. we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD (zeige ARSD Antikörper)) and mental retardation

  10. betaPix (zeige ARHGEF7 Antikörper) up-regulates NHE3 (zeige SLC9A3 Antikörper) membrane expression and activity by Shank2-mediated protein-protein interaction and by activating Rho GTPases in the apical regions of epithelial cells

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) Interaktionspartner

  1. Shank2 protein is involved in spinal NMDA receptor-mediated pain, and mutations of Shank2 may suppress NMDA-ERK (zeige EPHB2 Antikörper) signaling in spinal pain transmission.

  2. We found that Shank2 regulates excitatory synapse density, motor coordination, and specific repetitive and anxiety-like behaviors, but is not associated with autistic-like social deficits or repetitive behaviors.

  3. Shank2(-) (/) (-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain.

  4. trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1+/- mice

  5. Since mutations in all three human SHANK genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank mutant mice serve as corresponding in vivo model systems--{REVIEW}

  6. Shank2 appears to be a key molecule regulating epithelial fluid secretion.

  7. syndapin I (zeige PACSIN1 Antikörper) functions reflected direct, SH3 domain (zeige ITSN1 Antikörper)-mediated associations and functional interactions with ProSAP1/Shank2.

  8. Scaffolding proteins ProSAP1/2 were found within the postsynaptic specializations of synapses within the PNS, indicating a similar molecular assembly of central and peripheral postsynapses.

  9. Shank2 negatively regulates CFTR (zeige CFTR Antikörper) and this may play a significant role in maintaining epithelial homeostasis

  10. Data suggest that Shank 2 is expressed in the neurons of the developing retina and could play a critical role in the neuronal differentiation of the developing retina.

SHANK2 Antigen-Profil

Protein Überblick

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

Genbezeichner und Symbole assoziert mit SHANK2

  • SH3 and multiple ankyrin repeat domains 2 (SHANK2) Antikörper
  • SH3/ankyrin domain gene 2 (shank2) Antikörper
  • SH3 and multiple ankyrin repeat domains 2 (LOC100338286) Antikörper
  • SH3 and multiple ankyrin repeat domains 2 (Shank2) Antikörper
  • SH3 and multiple ankyrin repeat domains 2 (shank2) Antikörper
  • SH3/ankyrin domain gene 2 (Shank2) Antikörper
  • auts17 Antikörper
  • cortbp1 Antikörper
  • cttnbp1 Antikörper
  • MGC122482 Antikörper
  • mKIAA1022 Antikörper
  • prosap1 Antikörper
  • SHANK Antikörper
  • SHANK2 Antikörper
  • spank-3 Antikörper

Bezeichner auf Proteinebene für SHANK2

SH3 and multiple ankyrin repeat domains 2 , SH3 and multiple ankyrin repeat domains protein 2-like , GKAP/SAPAP interacting protein , SH3 and multiple ankyrin repeat domains protein 2 , cortactin SH3 domain-binding protein , cortactin-binding protein 1 , proline-rich synapse associated protein 1 , proline-rich synapse-associated protein 1 , GKAP/SAPAP-interacting protein , SH3/ankyrin domain gene 2 , proline rich synapse associated protein 1 , cortBP1

GENE ID SPEZIES
428858 Gallus gallus
100124731 Xenopus (Silurana) tropicalis
100338286 Oryctolagus cuniculus
100412179 Callithrix jacchus
466694 Pan troglodytes
708192 Macaca mulatta
747845 Pan troglodytes
100031879 Monodelphis domestica
100438523 Pongo abelii
100579795 Nomascus leucogenys
22941 Homo sapiens
171093 Rattus norvegicus
483677 Canis lupus familiaris
618649 Bos taurus
734458 Xenopus laevis
210274 Mus musculus
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