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SH2B1 encodes a member of the SH2-domain containing mediators family. Zusätzlich bieten wir Ihnen SH2B Adaptor Protein 1 Antikörper (65) und SH2B Adaptor Protein 1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Chromosome microarray analysis was performed on both twins and their parents. An identical 244 kb microdeletion on 16p11.2 including 9 Refseq genes, including SH2B1, was identified in the twins.
SH2B1 fine-tunes global-local chromatin states.
SH2B1 and RABEP1 genetic variants are associated with worsening of LDL and glucose parameters in patients treated with psychotropic drugs
SH2B1 polymorphisms are associated with HbA1c, largely independent of BMI, in European American young adults.
Results identified SH2B as a functional target of miR (zeige MLXIP Proteine)-361 which down-regulation suppresses lung cancer progression and metastasis through regulation of SH2B1.
that SH2B1 is a key positive mediator of pathological cardiac hypertrophy
Mutation analysis has demonstrated that variation in the SH2B1 gene is frequent in both lean and obese groups, with distinctive variations being present on either side of the weight spectrum.
The rs7359397 (SH2B1) was associated with the body weight, body mass index, and truncal fat mass reduction.
4 novel variants in SH2B1 were identified in individuals with obesity and insulin (zeige INS Proteine) resistance.
This study highlighted the importance of two candidate genes, SH2B1 and FAIM2 (zeige FAIM2 Proteine), in the risk of overweight/obesity.
data identify SH2B1 as a major regulator of IRS2 (zeige IRS2 Proteine) stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2 (zeige IRS2 Proteine), and identify 4E-BP2 (zeige EIF4EBP2 Proteine) as a major regulator of proliferation and survival of beta-cells.
SH2B1 in pancreatic beta-cells promotes insulin (zeige INS Proteine) synthesis and secretion at least in part by enhancing activation of JAK2 (zeige JAK2 Proteine) and/or Pdx1 (zeige PDX1 Proteine) pathways in response to hormonal and nutritional signals.
hepatic SH2B1 is not required for the maintenance of normal insulin (zeige INS Proteine) sensitivity and glucose metabolism; however, it regulates liver triacylglycerol synthesis, lipolysis, and VLDL secretion.
These data indicate that SH2B1 in beta-cells is an important prosurvival and proproliferative protein and promotes compensatory beta-cell expansion in the insulin (zeige INS Proteine)-resistant state and in response to beta-cell stress.
SH2B1 is responsive to erythropoietin (zeige EPO Proteine) stimulation and becomes phosphorylated
Leptin (zeige LEP Proteine)-stimulated activation of hypothalamic JAK2 (zeige JAK2 Proteine) and phosphorylation of hyphothalamic IRS2 (zeige IRS2 Proteine) were significantly impaired in SH2B1(-/-) mice.
Mutations in the SH2 domain of SH2B1 may increase the susceptibility to obesity and type 2 diabetes in a dominant-negative manner.
Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice; surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice.
These results suggest that SH2-Bbeta regulation of Akt partly participates in the NGF-mediated development of allergic airway challenge.
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.
SH2B adapter protein 1
, SH2B adaptor protein 1
, SH2B adapter protein 1-like
, SH2 domain-containing protein 1B
, SH2 domain-containing putative adapter SH2-B
, SH2-B signaling protein
, pro-rich, PH and SH2 domain-containing signaling mediator
, SH2-B PH domain containing signaling mediator 1
, SH2-B PH domain-containing signaling mediator 1
, fceRI gamma-chain-interacting protein SH2-B