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SH2D3C encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. Zusätzlich bieten wir Ihnen SH2 Domain Containing 3C Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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The structure of the NSP3-p130Cas (zeige BCAR1 Antikörper) complex reveals that this closed conformation is instrumental for interaction of NSP (zeige RTN1 Antikörper) proteins with a focal adhesion-targeting domain present in Cas (zeige CSE1L Antikörper) proteins.
This protein positively regulates T cell receptor-mediated interleukin-2 (zeige IL2 Antikörper) production by Jurkat cells.
SH2D3C (SHEP1) is less highly expressed than BCAR3 (zeige BCAR3 Antikörper) and NSP1 (zeige SH2D3A Antikörper) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.
NSP3 overexpression did not induce anti-estrogen resistance in breast tumor cell lines.
Shep1 plays a critical role in the in vivo regulation of Src (zeige SRC Antikörper) activity and Cas (zeige CTNND1 Antikörper) downstream signaling through Crk protein (zeige CRKL Antikörper).
SHEP1 and CasL (zeige NEDD9 Antikörper) are constitutively associated in B cells.
Shep1 plays an important role in the early ingrowth of peripheral olfactory sensory axons into the forebrain.
Sh2d3c is required for proper localization of cells, particularly marginal zone B cells in vivo; thymi of Sh2d3c-deficient mice show no maturational abnormalities.
glutamic acid mutation of tyrosine 635 makes SHEP1 unable to promote Cas (zeige CTNND1 Antikörper)-Crk (zeige CRK Antikörper) association, membrane ruffling, and cell migration toward epidermal growth factor (EGF (zeige EGF Antikörper)), implying that these activities of SHEP1 depend upon a physical interaction with Cas (zeige CTNND1 Antikörper)
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene.
SH2 domain containing 3C
, SH2 domain-containing protein 3C-like
, SH2 domain-containing Eph receptor-binding protein 1
, SH2 domain-containing protein 3C
, novel SH2-containing protein 3
, Cas/HEF1-associated signal transducer