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SMYD3 encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Zusätzlich bieten wir Ihnen SMYD3 Antikörper (75) und viele weitere Produktgruppen zu diesem Protein an.
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SMYD3 enhances tumorigenicity in esophageal squamous cell carcinoma by enhancing transcription of ezrin (zeige EZR Proteine) and LOXL2 (zeige LOXL2 Proteine), which are involved in proliferation, migration, and invasion.
SMYD3-mediated H2A.Z (zeige H2AFZ Proteine).1K101 dimethylation activates cyclin A1 (zeige CCNA1 Proteine) expression and contributes to driving the proliferation of breast cancer cells.
Substrate crevices of Smyd2 (zeige SMYD2 Proteine) and Smyd3 show distinct features in terms of spatial, hydration, and electrostatic properties that emphasize their characteristic modes of substrates interaction and entry pathways for inhibitor binding.
VNTR genotype 3/3 of the SMYD3 gene was associated with the risk of ovarian cancer.
The present results suggest that NS5A interacts with SMYD3 and induces AP-1 (zeige FOSB Proteine) activation, possibly by facilitating binding between HSP90 (zeige HSP90 Proteine) and SMYD3. This may be a novel mechanism of AP-1 (zeige FOSB Proteine) activation in HCV-infected cells.
SMYD3 physically interacts with the promoter of BCLAF1 and upregulates its expression by accumulating di- and trimethylation of H3K4 at the BCLAF1 locus. SMYD3 overexpression in bladder cancer cells promotes autophagy activation.
High expression of SMYD3 is associated with chronic lymphocytic leukemia.
results clearly revealed structural determinants for the substrate preference of SMYD3 and provided mechanistic insights into lysine methylation of MAP3K2 (zeige MAP3K2 Proteine).
A novel HBx-interacting protein (zeige HBXIP Proteine), SMYD3, was identified, leading to proposal of a novel mechanism of AP-1 (zeige FOSB Proteine) activation in HBV-infected cells.
Postulate that AdoMet (zeige MAT1A Proteine) cofactor acts like a key and locks Smyd3 in a closed conformation.
The transcription-potentiating function of Smyd3 is restricted to a particular set of genes.
Epigenetic control of Foxp3 (zeige FOXP3 Proteine) by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection.
These findings indicate that SMYD3 plays an important role in early embryonic lineage commitment and peri (zeige POSTN Proteine)-implantation development through the activation of lineage-specific genes.
represent the proof of principle that SMYD3 is a druggable target
methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas
SMYD3 depletion prevents muscle loss and fiber size decrease; findings reveal a mechanistic link between SMYD3/BRD4 (zeige BRD4 Proteine)-dependent transcriptional regulation, muscle mass determination, and skeletal muscle atrophy
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene.
SET and MYND domain containing 3
, SET and MYND domain-containing protein 3
, bA74P14.1 (novel protein)
, histone-lysine N-methyltransferase SMYD3
, zinc finger MYND domain-containing protein 1
, zinc finger protein, subfamily 3A (MYND domain containing), 1
, zinc finger, MYND domain containing 1
, SET and MYND domain-containing 3