SECIS Binding Protein 2 (SECISBP2) ELISA Kits

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. Zusätzlich bieten wir Ihnen SECIS Binding Protein 2 Antikörper (65) und und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus SECISBP2 SECISBP2 75420  
SECISBP2 79048 Q96T21
SECISBP2 79049 Q9QX72
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Ratte
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Weitere ELISA Kits für SECIS Binding Protein 2 Interaktionspartner

Mouse (Murine) SECIS Binding Protein 2 (SECISBP2) Interaktionspartner

  1. The results demonstrate that Secisbp2 is not strictly required for Sec incorporation and has a distinct role in stabilizing mRNAs that can be separated from its effects on UGA-redefinition

  2. Secisbp2 is essential for embryonic development and enhances selenoprotein expression.

  3. SBP2/SECIS complex activates eEFSec by directing functional interactions between Domain IV and the ribosome to promote Sec-tRNA(Sec) binding and accommodation into the ribosomal A-site

  4. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes.

Fruit Fly (Drosophila melanogaster) SECIS Binding Protein 2 (SECISBP2) Interaktionspartner

  1. Swapping only five amino acids between dSBP2 and human SBP2 in the K-rich domain conferred reversed SECIS-binding properties to the proteins, thus unveiling an important sequence for form 1 binding.

Human SECIS Binding Protein 2 (SECISBP2) Interaktionspartner

  1. SBP2 interacts directly with four proteins of the SMN (zeige STMN1 ELISA Kits) complex and the methylosome core proteins.

  2. SBP2 makes direct contacts with a discrete region of the human 28S rRNA.

  3. The patient showed typical symptoms of SBP2 deficiency, and novel compound heterozygous mutations were identified in SBP2 (p.M515fsX563/p.Q79X).

  4. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes.

  5. Describe subjects with compound heterozygous defects in the SECISBP2 gene. These individuals have reduced synthesis of most of the 25 known human selenoproteins, resulting in a complex phenotype.

  6. Results demonstrate that SECIS-binding protein 2 is required for protection against reactive oxygen species-induced cellular damage and cell survival.

  7. In addition to identifying key amino acids for SECIS recognition by SBP2, our findings led to the proposal that some of the recognition principles governing the 15.5 kD-U4 snRNA interaction must be similar in the SBP2-SECIS RNA complex

  8. Oxidative stress induces nuclear accumulation of SBP2 via oxidation of cysteine residues within a redox-sensitive cysteine-rich domain.

  9. Data suggest that SBP2 is a major determinant in dictating the hierarchy of selenoprotein synthesis via differential selenoprotein mRNA translation and sensitivity to nonsense-mediated decay.

  10. SECIS binding induces a conformational change in SBP2 that recruits eEFSec, which in concert with the Sec incorporation domain gains access to the ribosomal A site

SECIS Binding Protein 2 (SECISBP2) Antigen-Profil

Beschreibung des Gens

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.

Genbezeichner und Symbole assoziert mit SECISBP2

  • SECIS binding protein 2 (Secisbp2) Antikörper
  • SECIS-binding protein 2 (Sbp2) Antikörper
  • SECIS binding protein 2 (SECISBP2) Antikörper
  • SECIS binding protein 2 (secisbp2) Antikörper
  • 2210413N07Rik Antikörper
  • 2810012K13Rik Antikörper
  • CG7066 Antikörper
  • DKFZp459F1026 Antikörper
  • Dmel\\CG7066 Antikörper
  • Sbp2 Antikörper

Bezeichner auf Proteinebene für SECISBP2

selenocysteine insertion sequence-binding protein 2 , CG7066-PA , SECIS binding protein 2 , Sbp2-PA , selenocysteine insertion sequence-binding protein 2-like , SECIS-binding protein 2

GENE ID SPEZIES
75420 Mus musculus
38934 Drosophila melanogaster
426815 Gallus gallus
100036714 Xenopus (Silurana) tropicalis
100173231 Pongo abelii
464583 Pan troglodytes
697442 Macaca mulatta
100470097 Ailuropoda melanoleuca
100590393 Nomascus leucogenys
79048 Homo sapiens
476351 Canis lupus familiaris
100153797 Sus scrofa
511202 Bos taurus
79049 Rattus norvegicus
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