Runt-Related Transcription Factor 1 Proteine (RUNX1)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Zusätzlich bieten wir Ihnen RUNX1 Antikörper (279) und RUNX1 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Showing 8 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.107,93 €
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.142,86 €
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HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
457,14 €
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HOST_Escherichia coli (E. coli) Rind (Kuh) Unkonjugiert   5 applications Anmelden zum Anzeigen 5 bis 7 Tage
324,01 €
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RUNX1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

Am meisten referenzierte RUNX1 Proteine

  1. Human RUNX1 Protein expressed in HEK-293 Cells - ABIN2731253 : Mochin, Underwood, Cooper, McLenithan, Pierce, Nalvarte, Arbiser, Karlsson, Moise, Moskovitz, Passaniti: Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. in Microvascular research 2014 (PubMed)

Weitere Proteine zu Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartnern

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

  2. Leukaemogenesis by AML1-ETO (zeige RUNX1T1 Proteine) requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Proteine) formation.

  3. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 Proteine)-activatable receptor PAR-1 (protease-activated receptor-1 (zeige F2R Proteine)), in Runx1/Cbfb (zeige CBFB Proteine)-deleted MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells. Similar to the effect of Runx1/Cbfb (zeige CBFB Proteine) deletion, PAR-1 (zeige MARK2 Proteine) overexpression induced CDKN1A/p21 (zeige CDKN1A Proteine) expression and attenuated proliferation in MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells

  4. Immunohistochemical staining for RUNX1 showed reactivity in angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  5. The Runx1-persistent group is involved in transmitting mechanical and thermal information, whereas the Runx1-transient group transmits pruriceptive information. Such hierarchical control mechanisms may provide a developmental solution for the formation of sensory circuits that transmit distinct modalities.

  6. RUNX1 was expressed in both mesenchymal and epithelial compartments of the developing and postnatal lung. Increased respiratory distress, inflammation, and proinflammatory cytokines were observed in the Runx1-deleted mice after pulmonary LPS (zeige TLR4 Proteine) exposure. RUNX1 deletion was associated with the activation of NF-kappaB (zeige NFKB1 Proteine) in respiratory epithelial cells. RUNX1 was required for the suppression of NF-kappaB (zeige NFKB1 Proteine) signaling pathway.

  7. both repressor and activator functions of Runx1 at multiple hematopoietic stages and lineages likely contribute to the tumor suppressor activity in MDS (zeige MECOM Proteine) and AML.

  8. Knock-down of PLC-gamma-1 (zeige PLCG1 Proteine) induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 and subsequent PU.1 upregulation while subsequent rescue of RUNX1 in sh-PLC-gamma-1 (zeige PLCG1 Proteine)-transfected cells strongly inhibited foreign body giant cell formation.

  9. this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1, GATA-3 and Runx1) activate Bcl11b for T cell commitment

  10. Inhibition of Runx1 in multipotential myeloid precursor cells is important for osteoclast formation and function.

Human Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Heterozygous germ line mutations in the RUNX1 gene are responsible genetic events for FPD/AML.

  2. Data suggest that RUNX1 pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1, either mutations in RUNX1 gene or variations in expression of RUNX1, appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  3. The E3 ubiquitin ligase (zeige MUL1 Proteine) STUB1 (zeige STUB1 Proteine) is a negative regulator of both RUNX1 and RUNX1-RUNX1T1 (zeige RUNX1T1 Proteine). Activation of STUB1 (zeige STUB1 Proteine) could be a promising therapeutic strategy for RUNX1-RUNX1T1 (zeige RUNX1T1 Proteine) leukemia.

  4. The clinical significance of ETV6 (zeige ETV6 Proteine)-RUNX1.

  5. Deliver the necessary promotional drive for the progression of ETV6 (zeige ETV6 Proteine)-RUNX1+ pre-leukaemic cells.

  6. High RUNX1 expression is associated with pancreatic cancer.

  7. these findings have identified a novel function for Runx1 in sustaining normal mammary epithelial morphology and preventing epithelial-mesenchymal transition

  8. Leukaemogenesis by AML1-ETO (zeige RUNX1T1 Proteine) requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Proteine) formation.

  9. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 Proteine)-activatable receptor PAR-1 (protease-activated receptor-1 (zeige F2R Proteine)), in Runx1/Cbfb (zeige CBFB Proteine)-deleted MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells. Similar to the effect of Runx1/Cbfb (zeige CBFB Proteine) deletion, PAR-1 (zeige MARK2 Proteine) overexpression induced CDKN1A/p21 (zeige CDKN1A Proteine) expression and attenuated proliferation in MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells

  10. LRG1 (zeige LRG1 Proteine) plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC (zeige CALR Proteine)) by regulating RUNX1 expression.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (zeige CTCF Proteine) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (zeige MYEF2 Proteine) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (zeige RAD21 Proteine), or cohesin subunit Smc3 (zeige SMC3 Proteine), fail to express runx3 (zeige RUNX3 Proteine) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (zeige RUNX2 Proteine) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Protein Überblick

Protein Überblick

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit RUNX1

  • runt-related transcription factor 1 (RUNX1)
  • runt-related transcription factor (runt)
  • runt related transcription factor 1 (Runx1)
  • runt-related transcription factor 1 (runx1)
  • runt-related transcription factor 1 (Runx1)
  • AI462102 Protein
  • aml Protein
  • aml-1 Protein
  • Aml1 Protein
  • aml1-evi-1 Protein
  • amlcr1 Protein
  • cbfa2 Protein
  • evi-1 Protein
  • Pebp2a2 Protein
  • pebp2ab Protein
  • Pebpa2b Protein
  • Runx-1 Protein
  • runx1 Protein
  • runxa Protein
  • XAML Protein
  • Xaml1 Protein

Bezeichner auf Proteinebene für RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPEZIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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