Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) Proteine (RUNX1T1)

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Zusätzlich bieten wir Ihnen RUNX1T1 Antikörper (39) und RUNX1T1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
Ratte RUNX1T1 RUNX1T1 362489  
Direkt bei antikoerper-online bestellen
  • +49 (0)241 95 163 153
  • +49 (0)241 95 163 155
  • Online bestellen
  • orders@antikoerper-online.de

Top RUNX1T1 Proteine auf antikoerper-online.de

Showing 4 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details

RUNX1T1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartnern

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. Leukaemogenesis by AML1 (zeige RUNX1 Proteine)-ETO requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Proteine) formation.

  2. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (zeige RUNX1 Proteine)-175) of AML1 (zeige RUNX1 Proteine)-ETO is consistent with its contribution to the activity of full-length AML1 (zeige RUNX1 Proteine)-ETO and is mediated through its direct association with the DNA-binding domain

  3. the AML1 (zeige RUNX1 Proteine)-ETO fusion protein increases the expression of SIRT1 (zeige SIRT1 Proteine), possibly by binding to the promoter region of SIRT1 (zeige SIRT1 Proteine) to activate its transcription in t(8;21) AML (zeige RUNX1 Proteine).

  4. A feedback circuitry involving miR (zeige MLXIP Proteine)-9-1 and RUNX1 (zeige RUNX1 Proteine)-RUNX1T1.

  5. The role of RUNX1T1 in t(8;21) acute myeloid leukemia (zeige BCL11A Proteine) and miRNA expression regulation

  6. Our data revealed a novel role for RUNX1T1 as a tumor-suppressor gene in colorectal cancer through modulation of multiple cellular pathways affecting the cell cycle, DNA damage, DNA replication, estrogen signaling, and drug resistance

  7. Exon splicing patterns in the human RUNX1 (zeige RUNX1 Proteine)-RUNX1T1 fusion gene present in acute myeloid leukemia (zeige BCL11A Proteine) patients have been decoded.

  8. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1 (zeige RUNX1 Proteine)-ETO/RUNX1 (zeige RUNX1 Proteine)-RUNX1T1 is facilitated by interaction with the chaperonin (zeige HSPD1 Proteine) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (zeige HSP70 Proteine)).

  9. AML1/ETO transactivates gene expression through recruiting AP-1 to the AML1/ETO-AML1 complex.

  10. A substantial fraction of AML1 (zeige RUNX1 Proteine)-ETO/p300 (zeige EP300 Proteine) co-localization occurs near TSSs in promoter regions associated with transcriptionally active loci.

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. Leukaemogenesis by AML1 (zeige RUNX1 Proteine)-ETO requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Proteine) formation.

  2. Data show that RUNX1 (zeige RUNX1 Proteine)-ETO;c-Kit(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) in a fraction (51%) of reconstituted mice.

  3. Self-renewal induced by AML1 (zeige RUNX1 Proteine)/ETO in primary murine progenitors was inhibited when Aes (zeige AES Proteine) was decreased or absent.

  4. AML1 (zeige RUNX1 Proteine)-ETO synergizes with an ICSBP (zeige IRF8 Proteine) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  5. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (zeige CEBPB Proteine) and a novel regulator of early adipogenesis

  6. the loss of the molecular events of AML1 (zeige RUNX1 Proteine)-ETO C-terminal NCoR (zeige NCOR1 Proteine)/SMRT-interacting domain transforms AML1 (zeige RUNX1 Proteine)-ETO into a potent leukemogenic protein

  7. p15(Ink4b (zeige CDKN2B Proteine)) loss must be accompanied by additional oncogenic changes for RUNX1 (zeige RUNX1 Proteine)-ETO-associated AML (zeige RUNX1 Proteine) to develop

  8. AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the ETO NHR1 domain, are critical for the induction of acute myeloid leukemia by AML1-ETO9a

  9. the eTAFH-E protein interaction appears to contribute relatively little to the activity of AML1 (zeige RUNX1 Proteine)-ETO

RUNX1T1 Protein Überblick

Protein Überblick

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1)
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1)
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1)
  • AML1T1 Protein
  • Cbfa2t1 Protein
  • Cbfa2t1h Protein
  • CDR Protein
  • ETO Protein
  • MTG8 Protein
  • si:ch211-232j17.1 Protein
  • wu:fi14b07 Protein
  • zgc:154044 Protein
  • ZMYND2 Protein

Bezeichner auf Proteinebene für RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPEZIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
Ausgewählte Anbieter für RUNX1T1 Proteine (RUNX1T1)
Haben Sie etwas anderes gesucht?