Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) ELISA Kits

ROBO3 is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. Zusätzlich bieten wir Ihnen ROBO3 Antikörper (88) und ROBO3 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
ROBO3 64221 Q96MS0
Anti-Ratte ROBO3 ROBO3 315564  
Anti-Maus ROBO3 ROBO3 19649  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.06 ng/mL 15-0.06 ng/mL 96 Tests Anmelden zum Anzeigen 6 bis 8 Tage
541,62 €
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Weitere ELISA Kits für ROBO3 Interaktionspartner

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) Interaktionspartner

  1. This study show that this commissural neuron population includes spinal inhibitory neurons and sensory nociceptors and show that this population depends on Robo/Slit signaling yet crosses the dorsal midline in a Robo3-independent manner.

  2. These findings identify NELL2 (zeige NELL2 ELISA Kits) as an axon guidance cue and establish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 (zeige NELL2 ELISA Kits) repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose.

  3. results suggest that Robo3 evolution was key to sculpting the mammalian brain by converting a receptor for Slit repulsion into one that both silences Slit repulsion and potentiates Netrin attraction

  4. this study demonistrated that Robo3-driven axon midline crossing conditions functional maturation of a large commissural synapse.

  5. Rerouting climbing fibers to an ipsilateral projection reversed complex-spike modulation. Ptf1a (zeige PTF1A ELISA Kits)::cre;Robo3(lox/lox (zeige LOX ELISA Kits)) mice showed severe ataxia (zeige USP14 ELISA Kits) indicating the impact of climbing fi ber input on reciprocity of Purkinje cell fi ring during motor coordination.

  6. Posttranscriptional regulation of Robo3 mediated by Musashi-1 (zeige MSI1 ELISA Kits) controls midline crossing of precerebellar neurons.

  7. Pax-2 (zeige PAX2 ELISA Kits)/RB binding reverses repression of Rig-1 protein.

  8. The Slit receptors Robo2 (zeige ROBO2 ELISA Kits) and Robo3/Rig-1 are expressed in the subventricular zone and the rostral migratory stream and Slit1 (zeige SLIT1 ELISA Kits) and Slit2 (zeige SLIT2 ELISA Kits) are present in the adult septum and are responsible for both the septum and the CP repulsive activity in vitro

  9. Expression of Rig-1 protein by commissural axons is inversely correlated with Slit sensitivity. Removal of Rig-1 results in a total failure of commissural axons to cross.

  10. two functionally antagonistic isoforms of Robo3 with distinct carboxy termini arising from alternative splicing have been found

Human Roundabout, Axon Guidance Receptor, Homolog 3 (Drosophila) (ROBO3) Interaktionspartner

  1. confirmed that ROBO3 increases with clinical grade and miR (zeige MLXIP ELISA Kits)-383 expression is inversely correlated to that of ROBO3

  2. human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330

  3. We report the case of a 10-month-old girl with cross-fixation and inability to abduct who was genetically proven to have horizontal gaze palsy with progressive scoliosis (recessive ROBO3 mutations).

  4. Robo3.1A may prevent the Slit responsiveness by recruiting Robo1 (zeige ROBO1 ELISA Kits)/2 into a late endosome- and lysosome-dependent degradation pathway.

  5. The novel ROBO3 mutation in this family may be among the most deleterious

  6. This patient had clinical and neuroimaging characteristics considered pathognomonic of horizontal gaze palsy and progressive scoliosis and yet did not have ROBO3 mutations

  7. Three novel ROBO3 mutations have been identified in consanguineous patients with horizontal gaze palsy and progressive scoliosis.

  8. RIG-I (zeige DDX58 ELISA Kits) or melanoma differentiation-associated gene (MDA)5 (zeige IFIH1 ELISA Kits) signaling through mitochondrial antiviral signaling protein MAVS (zeige MAVS ELISA Kits) is required for activation of interferon (zeige IFNA ELISA Kits) (IFN)-beta (zeige IFNB1 ELISA Kits) production by rotavirus-infected intestinal epithelial cells.

  9. Slit3 (zeige SLIT1 ELISA Kits) inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis.

  10. mutations in the ROBO3 gene, which shares homology with roundabout (zeige ROBO1 ELISA Kits) genes important in axon guidance in developing Drosophila, zebrafish, and mouse.

ROBO3 Antigen-Profil

Beschreibung des Gens

This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

Genbezeichner und Symbole assoziert mit ROBO3

  • roundabout, axon guidance receptor, homolog 3 (Drosophila) (ROBO3) Antikörper
  • robo3 (robo3) Antikörper
  • roundabout, axon guidance receptor, homolog 3 (Drosophila) (Robo3) Antikörper
  • robo3 (TcasGA2_TC006743) Antikörper
  • roundabout 3 (robo3) Antikörper
  • roundabout homolog 3 (Drosophila) (Robo3) Antikörper
  • roundabout, axon guidance receptor, homolog 3 (LOC515936) Antikörper
  • CG5423 Antikörper
  • CG14345 Antikörper
  • CT17158 Antikörper
  • DKFZp468G0223 Antikörper
  • DmelCG5423 Antikörper
  • dRobo-3 Antikörper
  • HGPPS Antikörper
  • HGPS Antikörper
  • Rbig1 Antikörper
  • Rig-1 Antikörper
  • Rig1 Antikörper
  • Robo-3 Antikörper
  • robo3 Antikörper
  • Robo3a Antikörper
  • Robo3b Antikörper

Bezeichner auf Proteinebene für ROBO3

retinoblastoma inhibiting gene 1 , roundabout homolog 3 , roundabout-like protein 3 , robo3 , CG5423-PA , robo3-PA , roundabout, axon guidance receptor, homolog 3 , roundabout, axon guidance receptor, homolog 3 (Drosophila) , GLEAN_06743 , roundabout 3 , roundabout homolog 3-like , retinoblastoma-inhibiting gene 1 protein

GENE ID SPEZIES
64221 Homo sapiens
33314 Drosophila melanogaster
315564 Rattus norvegicus
466839 Pan troglodytes
489307 Canis lupus familiaris
658818 Tribolium castaneum
716274 Macaca mulatta
100072287 Equus caballus
100172083 Pongo abelii
100322880 Xenopus laevis
100342258 Oryctolagus cuniculus
100403106 Callithrix jacchus
100524637 Sus scrofa
100588193 Nomascus leucogenys
19649 Mus musculus
515936 Bos taurus
100858578 Gallus gallus
100337359 Bos taurus
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