Ring Finger and WD Repeat Domain 3 Proteine (RFWD3)

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. Zusätzlich bieten wir Ihnen RFWD3 Antikörper (29) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte RFWD3 RFWD3 361409  
RFWD3 55159 Q6PCD5
RFWD3 234736 Q8CIK8
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Top RFWD3 Proteine auf antikoerper-online.de

Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details

RFWD3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Ring Finger and WD Repeat Domain 3 (RFWD3) Interaktionspartnern

Horse (Equine) Ring Finger and WD Repeat Domain 3 (RFWD3) Interaktionspartner

  1. a polymorphism in the 3'-UTR of RFWD3 had a strong association with PATN1, which affects spotting patterns in horse coat color

Human Ring Finger and WD Repeat Domain 3 (RFWD3) Interaktionspartner

  1. Single point mutations in the RPA32 subunit of RPA that abolish interaction with RFWD3 also inhibit interstrand crossling repair, demonstrating that RPA-mediated RFWD3 recruitment to stalled replication forks is important for ICL repair.

  2. E3 ligase RFWD3 functions in timely removal and degradation of RPA (zeige RPA1 Proteine) and RAD51 (zeige RAD51 Proteine) to allow homologous recombination progression to subsequent steps following mitomycin C damage.

  3. RFWD3-dependent ubiquitination of RPA regulates repair at stalled replication forks.

  4. RFWD3 and RPA2 (zeige RPA2 Proteine) functionally interact and participate in replication checkpoint control

  5. RFWD3 is recruited to sites of DNA damage and facilitates RPA-mediated DNA damage signaling and repair

  6. Study identifies RFWD3 as a positive regulator of p53 (zeige TP53 Proteine) stability when the G(1) cell cycle checkpoint is activated and provides an explanation for how p53 (zeige TP53 Proteine) is protected from degradation in the presence of high levels of Mdm2 (zeige MDM2 Proteine).

RFWD3 Protein Überblick

Protein Überblick

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

Genbezeichner und Symbole assoziert mit RFWD3

  • ring finger and WD repeat domain 3 (Rfwd3)
  • ring finger and WD repeat domain 3 (RFWD3)
  • BC027246 Protein
  • RFWD3 Protein
  • RGD1305243 Protein
  • RNF201 Protein

Bezeichner auf Proteinebene für RFWD3

ring finger and WD repeat domain 3 , RING finger and WD repeat domain-containing protein 3-like , E3 ubiquitin-protein ligase RFWD3 , RING finger and WD repeat domain-containing protein 3 , RING finger protein 201

GENE ID SPEZIES
361409 Rattus norvegicus
415684 Gallus gallus
454242 Pan troglodytes
540072 Bos taurus
610424 Canis lupus familiaris
100055114 Equus caballus
100229473 Taeniopygia guttata
100387225 Callithrix jacchus
100461058 Pongo abelii
55159 Homo sapiens
234736 Mus musculus
Ausgewählte Anbieter für RFWD3 Proteine (RFWD3)
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