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The protein encoded by RNF123 contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. Zusätzlich bieten wir Ihnen RNF123 Antikörper (32) und viele weitere Produktgruppen zu diesem Protein an.
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p27 (zeige PAK2 Proteine) and its cognate ubiquitin ligases, Skp2/KPC/Pirh2 (zeige RCHY1 Proteine), are specifically involved in determining the clinical profiles of lung carcinomas.
RNF123 functions as a novel inhibitor of innate antiviral signaling mediated by RIG-I (zeige DDX58 Proteine) and MDA5 (zeige IFIH1 Proteine), a function that does not depend on its E3 ligase activity.
Suggest that RNF213 (zeige RNF213 Proteine) R4810K carriers have lower angiogenic capacities, indicating that they might be more susceptible to insults of cerebral hypoxia.
Study identified KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105 (zeige CDH13 Proteine), ubiquitinates it, and mediates its processing both under basal conditions and following signaling. Overexpression of KPC1 inhibits tumor growth likely mediated via excessive generation of p50 (zeige CD40 Proteine).
up-regulation of RNF123 was restricted to the cingulate cortex of patients with psychotic manifestations of the depression, supporting the role of the ubiquitin system in psychosis.
The number of patients with moyamoya disease, which is estimated at approximately one per 300 carriers of RNF123 polymorphism p.R4810K, is considered to be 53,800 in East Asian populations.
Our data support a role for RNF123 ubiquitin ligase in the degradation of HP1alpha (zeige CBX5 Proteine) and HP1beta (zeige CBX1 Proteine) upon lamin A/C (zeige LMNA Proteine) knock-down
This study deministrated that genome-wide significant quantitative trait locus was localized on chromsome 4p15 exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of the RNF123 gene) and disease risk.
Dendritic cell apoptosis was at least regulated by miR (zeige MLXIP Proteine)-221 and miR (zeige MLXIP Proteine)-155 through targeting the 3'-UTRs of p27kip1 (zeige CDKN1B Proteine) and Kip1 (zeige CDKN1B Proteine) ubiquitination-promoting complex 1 (KPC1), respectively.
KPC thus probably controls degradation of p27(Kip1 (zeige CDKN1B Proteine)) in G1 phase after export of the latter from the nucleus
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1.
E3 ubiquitin-protein ligase RNF123
, kip1 ubiquitination-promoting complex protein 1
, ubiquitin ligase