Ring Finger Protein 123 Proteine (RNF123)

The protein encoded by RNF123 contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. Zusätzlich bieten wir Ihnen RNF123 Antikörper (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RNF123 63891 Q5XPI4
RNF123 84585 Q5XPI3
Ratte RNF123 RNF123 100190936  
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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RNF123 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Ring Finger Protein 123 (RNF123) Interaktionspartnern

Human Ring Finger Protein 123 (RNF123) Interaktionspartner

  1. p27 (zeige PAK2 Proteine) and its cognate ubiquitin ligases, Skp2/KPC/Pirh2 (zeige RCHY1 Proteine), are specifically involved in determining the clinical profiles of lung carcinomas.

  2. RNF123 functions as a novel inhibitor of innate antiviral signaling mediated by RIG-I (zeige DDX58 Proteine) and MDA5 (zeige IFIH1 Proteine), a function that does not depend on its E3 ligase activity.

  3. Suggest that RNF213 (zeige RNF213 Proteine) R4810K carriers have lower angiogenic capacities, indicating that they might be more susceptible to insults of cerebral hypoxia.

  4. Study identified KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105 (zeige CDH13 Proteine), ubiquitinates it, and mediates its processing both under basal conditions and following signaling. Overexpression of KPC1 inhibits tumor growth likely mediated via excessive generation of p50 (zeige CD40 Proteine).

  5. up-regulation of RNF123 was restricted to the cingulate cortex of patients with psychotic manifestations of the depression, supporting the role of the ubiquitin system in psychosis.

  6. The number of patients with moyamoya disease, which is estimated at approximately one per 300 carriers of RNF123 polymorphism p.R4810K, is considered to be 53,800 in East Asian populations.

  7. Our data support a role for RNF123 ubiquitin ligase in the degradation of HP1alpha (zeige CBX5 Proteine) and HP1beta (zeige CBX1 Proteine) upon lamin A/C (zeige LMNA Proteine) knock-down

  8. This study deministrated that genome-wide significant quantitative trait locus was localized on chromsome 4p15 exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of the RNF123 gene) and disease risk.

  9. Dendritic cell apoptosis was at least regulated by miR (zeige MLXIP Proteine)-221 and miR (zeige MLXIP Proteine)-155 through targeting the 3'-UTRs of p27kip1 (zeige CDKN1B Proteine) and Kip1 (zeige CDKN1B Proteine) ubiquitination-promoting complex 1 (KPC1), respectively.

  10. KPC thus probably controls degradation of p27(Kip1 (zeige CDKN1B Proteine)) in G1 phase after export of the latter from the nucleus

RNF123 Protein Überblick

Protein Überblick

The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1.

Genbezeichner und Symbole assoziert mit RNF123

  • ring finger protein 123 (RNF123)
  • ring finger protein 123 (Rnf123)
  • BC003945 Protein
  • Kpc1 Protein

Bezeichner auf Proteinebene für RNF123

E3 ubiquitin-protein ligase RNF123 , kip1 ubiquitination-promoting complex protein 1 , ubiquitin ligase

GENE ID SPEZIES
484767 Canis lupus familiaris
100513177 Sus scrofa
63891 Homo sapiens
84585 Mus musculus
100190936 Rattus norvegicus
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