Rh Family C Glycoprotein Proteine (RHCG)

Functions as an electroneutral and bidirectional ammonium transporter. Zusätzlich bieten wir Ihnen Rh Family C Glycoprotein Antikörper (83) und Rh Family C Glycoprotein Kits (13) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RHCG 51458 Q9UBD6
Ratte RHCG RHCG 293048 Q7TNN9
RHCG 56315 Q9QXP0
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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RHCG Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Rh Family C Glycoprotein (RHCG) Interaktionspartnern

Human Rh Family C Glycoprotein (RHCG) Interaktionspartner

  1. The molecular mechanism of NH4(+) recruitment and NH3 transport by RHCG is described.

  2. Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion.

  3. RhAG (zeige RHAG Proteine), RhBG and RhCG-exhibit significant permeability to NH3 and show for the first time that RhBG and RhCG can conduct CO2.

  4. Amt (zeige AMT Proteine) and Rh proteins are not functionally equivalent and that permeation takes place according to two distinct mechanisms.

  5. X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport.

  6. major finding of this study is that RhCG protein is active as an NH(3) channel and that this function does not require any protein partner

  7. RhBG and RhCG facilitate ammonium movement across the plasma membrane; these results favor the hypothesis that these Rh glycoproteins, together with their homolog RhAG (zeige RHAG Proteine), constitute a family of NH3 channels in mammalian cells.

  8. RhCG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhCG-expressing cells.

  9. This study concludes that under normal conditions, RhCG is the major putative ammonia transporter expressed in the human kidney and RhBG is not expressed at detectable levels.

  10. Rhbg and Rhcg may contribute to bronchial epithelial cell ammonia metabolism and suggest that they do not contribute to pulmonary carbon dioxide transport.

Mouse (Murine) Rh Family C Glycoprotein (RHCG) Interaktionspartner

  1. We characterized ammonia and ammonium (NH3/NH4 (+)) transport by the rhesus-associated (Rh) glycoproteins RhAG, Rhbg, and Rhcg expressed in Xenopus oocytes. We used ion-selective microelectrodes and two-electrode voltage clamp to measure changes in intracellular pH, surface pH, and whole cell currents induced by NH3/NH4 (+) and methyl amine/ammonium (MA/MA(+)).

  2. investigated the renal adaptive response of acid excretory pathways to high-protein diets containing normal or low amounts of acid-producing sulfur amino acids (SAA (zeige SAA1 Proteine)) and examined how this adaption requires the RhCG ammonia transporter

  3. Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion.

  4. Rhcg is critically important in the renal response to metabolic acidosis. in mice with intact Rhcg expression, metabolic acidosis does not induce maximal changes in PEPCK (zeige PEPCK Proteine), NHE-3 (zeige SLC9A3 Proteine), and GS expression despite the presence of persistent metabolic acidosis.

  5. hypokalemia increases collecting duct Rhcg expression, and this likely contributes to the hypokalemia-stimulated increase in urinary ammonia excretion, and its adaptive increases in phosphate-dependent glutaminase (zeige GLS2 Proteine) expression can compensate for the absence of collecting duct Rhcg.

  6. Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct

  7. Rhcg expression in intercalated cells is necessary for the normal renal response to metabolic acidosis, contributing to both basal and acidosis-stimulated ammonia excretion. Adaptations in Rhbg expression occur in response to acid-loading.

  8. Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney.

  9. RhBG and RhCG are present in a major site of ammonia secretion in the kidney, i.e., the CNT and CD, in agreement with their putative role in ammonium transport.

  10. RhCG immunoreactivity is present in bile duct epithelial cells, where it may contribute to ammonium secretion into bile fluid.

Rh Family C Glycoprotein (RHCG) Protein Überblick

Protein Überblick

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Genbezeichner und Symbole assoziert mit RHCG

  • Rh family, C glycoprotein (RHCG)
  • Rh type C glycoprotein (LOC445729)
  • Rh family, C glycoprotein (Rhcg)
  • Rhesus blood group-associated C glycoprotein (Rhcg)
  • BB065800 Protein
  • C15orf6 Protein
  • PDRC2 Protein
  • RHGK Protein
  • SLC42A3 Protein

Bezeichner auf Proteinebene für RHCG

ammonia transporter RhCG , ammonium transporter Rh type C , Rh type C glycoprotein , Rhesus blood group, C glycoprotein , rh family type C glycoprotein , rh glycoprotein kidney , rhesus blood group family type C glycoprotein , tumor-related protein DRC2 , Rhesus blood group-associated C glycoprotein , Rhesus type C glycoprotein , rh type C glycoprotein , rhesus-associated C glycoprotein

GENE ID SPEZIES
100528009 Ovis aries
445729 Ciona intestinalis
51458 Homo sapiens
293048 Rattus norvegicus
479040 Canis lupus familiaris
733644 Sus scrofa
281456 Bos taurus
415490 Gallus gallus
100009494 Oryctolagus cuniculus
664731 Macaca mulatta
453638 Pan troglodytes
56315 Mus musculus
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