Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) Proteine (RDH12)

Exhibits an oxidoreductive catalytic activity towards retinoids. Zusätzlich bieten wir Ihnen RDH12 Antikörper (22) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RDH12 77974 Q8BYK4
RDH12 145226 Q96NR8
Ratte RDH12 RDH12 314264  
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Showing 7 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 11 bis 15 Tage
387,62 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Anmelden zum Anzeigen 15 bis 16 Tage
324,76 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.711,59 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
484,01 €
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RDH12 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Am meisten referenzierte RDH12 Proteine

  1. Human RDH12 Protein expressed in Escherichia coli (E. coli) - ABIN668007 : Keller, Adamski: RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism. in The Journal of steroid biochemistry and molecular biology 2007 (PubMed)
    Zeige alle 2 Referenzen für 668007

Weitere Proteine zu Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Interaktionspartnern

Mouse (Murine) Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Interaktionspartner

  1. RDH12 in inner segments can protect vital cell organelles against aldehyde toxicity caused by an intracellular leak of all-trans-retinal, as well as other aldehydes originating both inside and outside the cell.

  2. RDH12 plays a unique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the eye.

  3. The present findings, together with those of earlier studies showing only minor functional deficits in mice deficient for Rdh5 (zeige RDH5 Proteine), Rdh8 (zeige HSD17B6 Proteine), or Rdh11 (zeige RDH11 Proteine), suggest that the activity of any one isoform is not rate limiting in the visual response.

  4. Oxidative stress induced (zeige SQSTM1 Proteine) by exposure to constant bright light led to a rapid and significant decrease of RDH12 protein. The low and constant expression of RDH11 (zeige RDH11 Proteine) suggested a housekeeping function for this enzyme.

  5. a critical function of RDH12 is the reduction of all-trans-retinal that exceeds the reductive capacity of the photoreceptor outer segments

Human Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Interaktionspartner

  1. We report 4 children from 3 consanguineous families with bilateral elevation deficiency in the context of retinal dystrophy (zeige MERTK Proteine). All were found to harbor recessive mutations in retinal dehydrogenase 12 (RDH12).

  2. Mutations in the AIPL1 (zeige AIPL1 Proteine) and RDH12 genes associated with leber congenital amaurosis in two Turkish families.

  3. Here we demonstrate that microtubule-associated protein 1 light chain 3A (zeige MAP1LC3A Proteine) (LC3A (zeige MAP1LC3A Proteine)), a marker of autophagy, is related to hypoxia and poor prognosis in clear cell ovarian cancer.

  4. The three patients with Leber congenital amaurosis/early-onset retinal dystrophy (zeige MERTK Proteine) had a progressive decrease of their vision with the formation of a posterior staphyloma.

  5. Two novel missense mutations in the RDH12 gene are associated with retinitis pigmentosa.

  6. Seventeen novel mutations in the RDH12 gene were identified that accounted for approximately 7% of disease in a cohort of patients diagnosed with Leber congenital amaurosis and early-onset retinal dystrophy (zeige MERTK Proteine).

  7. LCA (zeige CLTA Proteine) has been associated with sequence variations of 14 different genes; in approximately 30% of all cases pathogenic mutations remain to be determined.

  8. The retina RDH12 reduces 4-HNE (zeige ELANE Proteine) to a nontoxic alcohol, protecting cellular macromolecules against oxidative modification and protecting photoreceptors from light-induced apoptosis.

  9. Results suggest that the accelerated degradation of RDH12 mutants by the ubiquitin-proteasome system contributes to the pathophysiology and phenotypic variability associated with mutations in the RDH12 gene.

  10. Our studies show that RDH12 is associated with retinal dystrophy (zeige MERTK Proteine) and encodes an enzyme with a unique, nonredundant role in the photoreceptor cells.

RDH12 Protein Überblick

Protein Überblick

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments (By similarity).

Genbezeichner und Symbole assoziert mit RDH12

  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (RDH12)
  • retinol dehydrogenase 12 (all-trans and 9-cis) (rdh12)
  • retinol dehydrogenase 12 (MAV_1968)
  • retinol dehydrogenase 12 (CC1G_02720)
  • Retinol dehydrogenase 12 (Bm1_36660)
  • retinol dehydrogenase 12 (PTRG_03574)
  • retinol dehydrogenase 12 (PTRG_05326)
  • retinol dehydrogenase 12 (PTRG_08067)
  • retinol dehydrogenase 12 (LOC100282710)
  • retinol dehydrogenase 12 (LOC100285880)
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (LOC100226769)
  • retinol dehydrogenase 12 (Rdh12)
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (Rdh12)
  • A930033N07Rik Protein
  • DSSDR2 Protein
  • LCA3 Protein
  • LCA13 Protein
  • RP53 Protein
  • SDR7C2 Protein
  • wu:fj43a10 Protein
  • zgc:92430 Protein

Bezeichner auf Proteinebene für RDH12

retinol dehydrogenase 12 (all-trans and 9-cis) , retinol dehydrogenase 12 , Retinol dehydrogenase 12 , retinol dehydrogenase 12 (all-trans/9-cis/11-cis) , all-trans and 9-cis retinol dehydrogenase , retinol dehydrogenase 12, all-trans and 9-cis , short chain dehydrogenase/reductase family 7C, member 2 , double substrate specificity short chain dehydrogenase/reductase 2 , double substrate specificity short-chain dehydrogenase/reductase 2 , double substrate-specificity short chain dehydrogenase/reductase 2

GENE ID SPEZIES
423274 Gallus gallus
436597 Danio rerio
4528332 Mycobacterium avium 104
6016890 Coprinopsis cinerea okayama7130
6102217 Brugia malayi
6341805 Pyrenophora tritici-repentis Pt-1C-BFP
6343577 Pyrenophora tritici-repentis Pt-1C-BFP
6346345 Pyrenophora tritici-repentis Pt-1C-BFP
100282710 Zea mays
100285880 Zea mays
490744 Canis lupus familiaris
711438 Macaca mulatta
100226769 Taeniopygia guttata
77974 Mus musculus
145226 Homo sapiens
314264 Rattus norvegicus
369021 Bos taurus
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