anti-Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Antikörper

Exhibits an oxidoreductive catalytic activity towards retinoids. Zusätzlich bieten wir Ihnen RDH12 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
RDH12 77974 Q8BYK4
RDH12 145226 Q96NR8
RDH12 314264  
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Top anti-RDH12 Antikörper auf antikoerper-online.de

Showing 10 out of 22 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Hund Kaninchen Unkonjugiert WB <b>WB Suggested Anti-RDH12 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Transfected 293T 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-RDH12 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Human Intestine 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$433.13
Details
Human Maus Unkonjugiert IF, ELISA, WB Detection limit for recombinant GST tagged RDH12 is 0.3 ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to RDH12 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$430.00
Details
Human Kaninchen Unkonjugiert WB Western Blot: RDH12 Antibody [NBP1-58017] - Human Fetal Intestine, concentration 0.2-1 ug/ml. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Kaninchen Unkonjugiert WB Western Blot analysis of RDH12 expression in transfected 293T cell line by RDH12 MaxPab polyclonal antibody.<br><br>Lane 1: RDH12 transfected lysate(35.10 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$418.57
Details
Human Maus Unkonjugiert WB Western Blot analysis of RDH12 expression in transfected 293T cell line by RDH12 MaxPab polyclonal antibody.<br><br>Lane 1: RDH12 transfected lysate(34.76 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Anmelden zum Anzeigen 11 bis 12 Tage
$430.00
Details
Human Kaninchen Unkonjugiert ELISA, WB   150 μL Anmelden zum Anzeigen 13 bis 16 Tage
$753.50
Details

RDH12 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Mouse (Murine)


Human
,
,
Rat (Rattus)


Am meisten referenzierte anti-RDH12 Antikörper

  1. Dog (Canine) Polyclonal RDH12 Primary Antibody für WB - ABIN2785175 : Sun, Gerth, Maeda, Lodowski, Van Der Kraak, Saperstein, Héon, Palczewski: Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. in Vision research 2007 (PubMed)

Weitere Antikörper gegen RDH12 Interaktionspartner

Mouse (Murine) Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Interaktionspartner

  1. RDH12 in inner segments can protect vital cell organelles against aldehyde toxicity caused by an intracellular leak of all-trans-retinal, as well as other aldehydes originating both inside and outside the cell.

  2. RDH12 plays a unique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the eye.

  3. The present findings, together with those of earlier studies showing only minor functional deficits in mice deficient for Rdh5 (zeige RDH5 Antikörper), Rdh8 (zeige HSD17B6 Antikörper), or Rdh11 (zeige RDH11 Antikörper), suggest that the activity of any one isoform is not rate limiting in the visual response.

  4. Oxidative stress induced (zeige SQSTM1 Antikörper) by exposure to constant bright light led to a rapid and significant decrease of RDH12 protein. The low and constant expression of RDH11 (zeige RDH11 Antikörper) suggested a housekeeping function for this enzyme.

  5. a critical function of RDH12 is the reduction of all-trans-retinal that exceeds the reductive capacity of the photoreceptor outer segments

Human Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Interaktionspartner

  1. We report 4 children from 3 consanguineous families with bilateral elevation deficiency in the context of retinal dystrophy (zeige MERTK Antikörper). All were found to harbor recessive mutations in retinal dehydrogenase 12 (RDH12).

  2. Mutations in the AIPL1 (zeige AIPL1 Antikörper) and RDH12 genes associated with leber congenital amaurosis in two Turkish families.

  3. Here we demonstrate that microtubule-associated protein 1 light chain 3A (zeige MAP1LC3A Antikörper) (LC3A (zeige MAP1LC3A Antikörper)), a marker of autophagy, is related to hypoxia and poor prognosis in clear cell ovarian cancer.

  4. The three patients with Leber congenital amaurosis/early-onset retinal dystrophy (zeige MERTK Antikörper) had a progressive decrease of their vision with the formation of a posterior staphyloma.

  5. Two novel missense mutations in the RDH12 gene are associated with retinitis pigmentosa.

  6. Seventeen novel mutations in the RDH12 gene were identified that accounted for approximately 7% of disease in a cohort of patients diagnosed with Leber congenital amaurosis and early-onset retinal dystrophy (zeige MERTK Antikörper).

  7. LCA (zeige CLTA Antikörper) has been associated with sequence variations of 14 different genes; in approximately 30% of all cases pathogenic mutations remain to be determined.

  8. The retina RDH12 reduces 4-HNE (zeige ELANE Antikörper) to a nontoxic alcohol, protecting cellular macromolecules against oxidative modification and protecting photoreceptors from light-induced apoptosis.

  9. Results suggest that the accelerated degradation of RDH12 mutants by the ubiquitin-proteasome system contributes to the pathophysiology and phenotypic variability associated with mutations in the RDH12 gene.

  10. Our studies show that RDH12 is associated with retinal dystrophy (zeige MERTK Antikörper) and encodes an enzyme with a unique, nonredundant role in the photoreceptor cells.

RDH12 Antigen-Profil

Protein Überblick

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments (By similarity).

Genbezeichner und Symbole assoziert mit RDH12

  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (RDH12) Antikörper
  • retinol dehydrogenase 12 (all-trans and 9-cis) (rdh12) Antikörper
  • retinol dehydrogenase 12 (MAV_1968) Antikörper
  • retinol dehydrogenase 12 (CC1G_02720) Antikörper
  • Retinol dehydrogenase 12 (Bm1_36660) Antikörper
  • retinol dehydrogenase 12 (PTRG_03574) Antikörper
  • retinol dehydrogenase 12 (PTRG_05326) Antikörper
  • retinol dehydrogenase 12 (PTRG_08067) Antikörper
  • retinol dehydrogenase 12 (LOC100282710) Antikörper
  • retinol dehydrogenase 12 (LOC100285880) Antikörper
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (LOC100226769) Antikörper
  • retinol dehydrogenase 12 (Rdh12) Antikörper
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (Rdh12) Antikörper
  • A930033N07Rik Antikörper
  • DSSDR2 Antikörper
  • LCA3 Antikörper
  • LCA13 Antikörper
  • RP53 Antikörper
  • SDR7C2 Antikörper
  • wu:fj43a10 Antikörper
  • zgc:92430 Antikörper

Bezeichner auf Proteinebene für RDH12

retinol dehydrogenase 12 (all-trans and 9-cis) , retinol dehydrogenase 12 , Retinol dehydrogenase 12 , retinol dehydrogenase 12 (all-trans/9-cis/11-cis) , all-trans and 9-cis retinol dehydrogenase , retinol dehydrogenase 12, all-trans and 9-cis , short chain dehydrogenase/reductase family 7C, member 2 , double substrate specificity short chain dehydrogenase/reductase 2 , double substrate specificity short-chain dehydrogenase/reductase 2 , double substrate-specificity short chain dehydrogenase/reductase 2

GENE ID SPEZIES
423274 Gallus gallus
436597 Danio rerio
4528332 Mycobacterium avium 104
6016890 Coprinopsis cinerea okayama7130
6102217 Brugia malayi
6341805 Pyrenophora tritici-repentis Pt-1C-BFP
6343577 Pyrenophora tritici-repentis Pt-1C-BFP
6346345 Pyrenophora tritici-repentis Pt-1C-BFP
100282710 Zea mays
100285880 Zea mays
490744 Canis lupus familiaris
711438 Macaca mulatta
100226769 Taeniopygia guttata
77974 Mus musculus
145226 Homo sapiens
314264 Rattus norvegicus
369021 Bos taurus
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