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Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. Zusätzlich bieten wir Ihnen Relaxin 1 Kits (43) und Relaxin 1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal RLN1 Primary Antibody für WB - ABIN611049
Fernandes-Alnemri, Litwack, Alnemri: CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. in The Journal of biological chemistry 1995
Show all 3 Pubmed References
The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review)
a novel fusion transcript comprising the RLN1 and RLN2 genes, was identified.
Although serum relaxin level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS.
Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Rln enhanced synergistically BMP-2 (zeige BMP2 Antikörper)-induced osteoblast differentiation and bone formation.
Relaxin actions in pregnancy include increasing cervical pro-MMP-1 (zeige MMP1 Antikörper) and pro-MMP-3 (zeige MMP3 Antikörper) and decreasing TIMP-1 (zeige TIMP1 Antikörper), changes which soften the cervix.
For the first time, we bring together the systemic (ovarian) and autocrine/paracrine (intrauterine) sources of RLN, in an attempt to understand how RLN contributes to premature birth in women.
Notch (zeige NOTCH1 Antikörper) signaling can down-regulate TGF-beta1 (zeige TGFB1 Antikörper)/Smad3 (zeige SMAD3 Antikörper)-induced fibroblast-myofibroblast transition and that RLX could exert its well known anti-fibrotic action through the up-regulation of this pathway.
Recombinant human relaxin (RLX) may provide a novel therapy to manage atrial fibrillation in humans by reversing fibrosis and hypertrophy and by modulating cardiac ionic currents.
relaxin may promote the proliferation, invasion and metastasis of osteosarcoma cells by regulating the expression of MMP-9 (zeige MMP9 Antikörper) and facilitating ECM (zeige MMRN1 Antikörper) degradation.
This study tested the hypothesis that functional adaptation of the mesenteric and uterine arteries during pregnancy will be compromised in relaxin-deficient mice.
Passive mechanical wall properties differed at younger ages, suggesting that Relaxin expression has only minor effects on vascular aging.
we demonstrate endothelial dysfunction and impaired arterial wall remodeling in male mice deficient in relaxin. Thus, our results highlight a role for endogenous relaxin in the maintenance of normal mesenteric artery structure and function in males.
data suggest a novel role for Rln in craniofacial skeletal development and metabolism through Rxfp2 (zeige RXFP2 Antikörper)
Relaxin and estrogen enhance matrix loss in the temporomandibular joint disc.
Relaxin deficiency compromises uterine artery remodeling in older pregnant females.
RLX improves impaired wound healing, enhances staining of MMP-11 (matrix metalloproteinase-11 (zeige MMP11 Antikörper)) and increases wound-breaking strength at day 12 in diabetic mice.
Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice
Data suggest that in proximal colon, relaxin affects constitutive nNOS (neuronal nitric oxide synthase (zeige NOS1 Antikörper)) and eNOS (zeige NOS3 Antikörper) (endothelial cell NOS (zeige NOS Antikörper)) but not iNOS (inducible NOS (zeige NOS2 Antikörper)), increasing enzyme activity and reducing muscle tone.
We established a non-human primate model of early human pregnancy to study the effects of relaxin in vivo.
Relaxin serves as a model for understanding lactocrine signals that support development of neonatal tissues.
Swine relaxin provides protection against ischemia-reperfusion-induced renal injury in rats by reducing apoptosis and inflammation.
Establishment of the neonatal porcine uterine developmental program requires maternal lactocrine support via relaxin.
Relaxin was detected in denuded oocytes, cumulus cells, mature boar spermatozoa, zygotes, and embryos (cleaved and blastocysts).
Exogenous relaxin influences its own receptors expression, improves oocyte nuclear maturation. Its beneficial effect on total cell number of blastocysts appears to be through a Bcl2 (zeige BCL2 Antikörper)-like1/Bax (zeige BAX Antikörper)-independent mechanism.
This study provides evidence for expression of RLN-RXFP1 ligand-receptor system in the boar testis, suggesting that the testes act as a source and possible target tissue of RLN.
Changes of relaxin mRNA are correlated with changes of the hormone in the CL during pregnancy, suggesting that the relaxin level is determined by the amount of mRNA available for translation.
Relaxin-producing C2C12 myoblasts displayed greater efficacy to engraft the post-ischaemic scar and to induce extracellular matrix re-modelling and angiogenesis as compared with the control cells
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. This encoded protein is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds; however, their exact cleavage sites have not been described. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. This gene has multiple polyadenylation sites. There are multiple alternatively spliced transcript variants described for this gene but their full length nature is not known yet.
, prorelaxin H1
, prorelaxin 1
, Relaxin 1 (H1)
, relaxin 1