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RRAS2 encodes a member of the R-Ras subfamily of Ras-like small GTPases. Zusätzlich bieten wir Ihnen Related RAS Viral (R-Ras) Oncogene Homolog 2 Antikörper (55) und Related RAS Viral (R-Ras) Oncogene Homolog 2 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
Equilibrium dissociation constants were determined for the binding of HRAS, KRAS, NRAS and RRAS2 to the RAS binding (RB) domain of binding proteins.
This article is the first study demonstrating expression of TC21 in human skin malignant tumors and suggests that TC21 is more expressed in highly aggressive skin tumors.
Suggest that TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin (zeige CDH1 ELISA Kits) and N-cadherin (zeige CDH2 ELISA Kits) in hepatocellular carcinoma and is associated with tumor progression and poor prognosis in HCC (zeige FAM126A ELISA Kits).
RasGRF GEFs can activate TC21 in all sublocalizations except the Golgi complex. Farnesylated TC21 can be activated by RasGRF1 (zeige RASGRF1 ELISA Kits) & RasGRF2 (zeige RASGRF2 ELISA Kits), but geranylgeranylated TC21 is unresponsive to RasGRF2 (zeige RASGRF2 ELISA Kits).
TGF-beta (zeige TGFB1 ELISA Kits) and TC21 have roles in tumorigenesis
TC21 directly links antigen receptors to PI(3 (zeige PI3 ELISA Kits))K-mediated survival pathways.
SIRT6 (zeige SIRT6 ELISA Kits), a sirtuin (zeige SIRT1 ELISA Kits) with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.
The RLIP76 (zeige RALBP1 ELISA Kits)/R-Ras/ARNO (zeige CYTH2 ELISA Kits) complex localizes to recycling endosomes.RLIP76 is a linker protein (zeige LAT ELISA Kits) connecting R-Ras to ARNO (zeige CYTH2 ELISA Kits).
findings reveal R-Ras2 as a critical regulator of TGF-beta (zeige TGFB1 ELISA Kits) signaling in vivo.
Data indicate that RRas2(-/-) mice show no major alterations in viability, growth rates, cardiovascular parameters, or fertility.
PI3K, but not RalGDS (zeige RALGDS ELISA Kits), is an important mediator of cell proliferation by TC21.
role of TC21/R-Ras2 activation in the migration of neurofibromin (zeige NF1 ELISA Kits)-deficient Schwann cells
Data suggest that R-Ras and TC-21 play a role in facilitating branching and growth in early ureteric bud development, whereas H-Ras (zeige HRAS ELISA Kits) might favor cell migration and elongation of tubules, events that occur later in development.
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants.
Ras-related protein R-Ras2
, ras-like protein TC21
, ras-related protein R-Ras2
, teratocarcinoma oncogene